Trastuzumab

ChemicalBook > CAS DataBase List > Trastuzumab

Product Name: Trastuzumab
CAS No.: 180288-69-1
Chemical Name: Trastuzumab
Synonyms: Herceptin;Trastuzumab Beta;RhuMab HER2;TRASTUZUMAB 95 % +;TRASTUZUMAB 98 % +;Trastuzumab USP/EP/BP;TrastuzuMab(Herceptin);Trastuzumab (anti-HER2);Trastuzumab,Stock solution;Trastuzumab - 20mg/ml in PBS
CBNumber: CB61074602
Molecular Formula: C10H14N6O5
Formula Weight: 298.25536
MOL File: 180288-69-1.mol

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Trastuzumab Property

storage temp.: Store at -20°C

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Safety

Hazardous Substances Data: 180288-69-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H360May damage fertility or the unborn child

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FT65040
Product name: Trastuzumab - 20mg/ml in PBS
Packaging: 1mg
Price: $78
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT65040
Product name: Trastuzumab - 20mg/ml in PBS
Packaging: 2mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-7821
Product name: Trastuzumab
Purity: 99.30%
Packaging: 1mg
Price: $192
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT65040
Product name: Trastuzumab - 20mg/ml in PBS
Packaging: 5mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT65040
Product name: Trastuzumab - 20mg/ml in PBS
Packaging: 10mg
Price: $420
Updated: 2021/12/16

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Trastuzumab Chemical Properties,Usage,Production

Uses

Trastuzumab is used to treat breast cancer. It is effective against tumors that overexpress the HER2/neu protien. As part of chemotherapy regimen for adjuvant treatment of lymph-node positive, HER2/neu positive cancer.

Indications

The introduction of herceptin (Trastuzumab) into clinical practice for the treatment of breast cancer marks a major advance in the use of monoclonal antibody cancer therapy. Herceptin is a humanized antibody directed against the HER-2 antigen that is overexpressed on the tumor cell surface in approximately 25% of breast cancer patients. HER-2/neu/erbB2 overexpression marks an aggressive estrogen receptor–negative form of breast cancer. Therefore, a therapeutic agent selective for this target is particularly valuable. Herceptin is administered by intravenous infusion and in conjunction with paclitaxel can extend survival in patients with HER-2/neu/erbB2 overexpressing metastatic breast cancer.Herceptin use is associated with infusion- related hypotension, flushing and bronchoconstriction, and skin rash but no bone marrow toxicity. Herceptin appears to sensitize patients to cardiotoxicity, an important concern in patients also receiving doxorubicin.

Definition

Herceptin (generic name: trastuzumab) is not a chemo drug, it is a targeted therapy anticancer drug.
Herceptin contains one active ingredient, trastuzumab, and is given as an intravenous (IV) infusion slowly into a vein. Herceptin Hylecta contains two active ingredients, trastuzumab and hyaluronidase-oysk, and is given as a subcutaneous injection, which is an injection that goes under the skin.

Mechanism of action

Trastuzumab is a monoclonal antibody against human epidermal growth factor receptor 2 (HER2). Trastuzumab binds to an extracellular domain of this receptor and inhibits HER2 homodimerization, thereby preventing HER2-mediated signaling. It is also thought to facilitate antibody-dependent cellular cytotoxicity, leading to the death of cells that express HER2. Its mechanism differs slightly from that of the newer agent pertuzumab; the latter inhibits hetero-dimerization of HER2 with HER3, a related growth factor receptor. Trastuzumab has been shown to bind three distinct regions of domain IV of the HER2 extracellular domain through electrostatic and hydrophobic bindings[1].

References

[1] Hamid Maadi. “Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma.” Cancers (2021).

Trastuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Trastuzumab manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Trastuzumab 180288-69-1
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-09

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Trastuzumab 180288-69-1
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-01-10

Dideu Industries Group Limited

Product: Trastuzumab 180288-69-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

180288-69-1, TrastuzumabRelated Search:

METHYL ISOCYANOACETATE Ethyl isocyanoacetate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) TERT-BUTYL ISOCYANIDE Cupric acetylacetonate Aluminum acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE SALCOMINE Benzyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 2,4-PENTANEDIONE, SILVER DERIVATIVE Tosylmethyl isocyanide Ferric acetylacetonate

Herceptin

TrastuzuMab(Herceptin)

TRASTUZUMAB 98 % +

IMMunoglobulin G1,anti-(huMan p185neu receptor) (huMan-Mouse Monoclonal rhuMab HER2 g1-chain), disulfide with huMan-MouseMonoclonal rhuMab HER2 light chain, diMer

TRASTUZUMAB 95 % +

Anti HER2, Ig gamma-1 chain C region

Recombinant humanized anti-HER2 antibody

RhuMab HER2

Trastuzumab - 20mg/ml in PBS

Trastuzumab,Stock solution

Trastuzumab (anti-HER2)

Trastuzumab Beta

Trastuzumab USP/EP/BP

Research Grade Trastuzumab(DHC09601)

EGFR,Trastuzumab,Anti-Human HER2, Humanized Antibody,Epidermal growth factor receptor,HER1,inhibit,ErbB-1,Inhibitor

Anti-Human HER2, Humanized Antibody

180288-69-1