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Trastuzumab

Product Name
Trastuzumab
CAS No.
180288-69-1
Chemical Name
Trastuzumab
Synonyms
Herceptin;Trastuzumab Beta;RhuMab HER2;Anti-Trastuzumab;TRASTUZUMAB 95 % +;TRASTUZUMAB 98 % +;Trastuzumab USP/EP/BP;TrastuzuMab(Herceptin);Trastuzumab (anti-HER2);Trastuzumab,Stock solution
CBNumber
CB61074602
Molecular Formula
C10H14N6O5
Formula Weight
298.25536
MOL File
180288-69-1.mol
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Trastuzumab Property

storage temp. 
Store at -20°C
form 
Solid
color 
White to light yellow
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Safety

Hazardous Substances Data
180288-69-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FT65040
Product name
Trastuzumab - 20mg/ml in PBS
Packaging
1mg
Price
$78
Updated
2021/12/16
Biosynth Carbosynth
Product number
FT65040
Product name
Trastuzumab - 20mg/ml in PBS
Packaging
2mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-7821
Product name
Trastuzumab
Purity
99.30%
Packaging
1mg
Price
$192
Updated
2021/12/16
Biosynth Carbosynth
Product number
FT65040
Product name
Trastuzumab - 20mg/ml in PBS
Packaging
5mg
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FT65040
Product name
Trastuzumab - 20mg/ml in PBS
Packaging
10mg
Price
$420
Updated
2021/12/16
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Trastuzumab Chemical Properties,Usage,Production

Uses

Trastuzumab is used to treat breast cancer. It is effective against tumors that overexpress the HER2/neu protien. As part of chemotherapy regimen for adjuvant treatment of lymph-node positive, HER2/neu positive cancer.

Indications

The introduction of herceptin (Trastuzumab) into clinical practice for the treatment of breast cancer marks a major advance in the use of monoclonal antibody cancer therapy. Herceptin is a humanized antibody directed against the HER-2 antigen that is overexpressed on the tumor cell surface in approximately 25% of breast cancer patients. HER-2/neu/erbB2 overexpression marks an aggressive estrogen receptor–negative form of breast cancer. Therefore, a therapeutic agent selective for this target is particularly valuable. Herceptin is administered by intravenous infusion and in conjunction with paclitaxel can extend survival in patients with HER-2/neu/erbB2 overexpressing metastatic breast cancer.Herceptin use is associated with infusion- related hypotension, flushing and bronchoconstriction, and skin rash but no bone marrow toxicity. Herceptin appears to sensitize patients to cardiotoxicity, an important concern in patients also receiving doxorubicin.

Definition

Herceptin (generic name: trastuzumab) is not a chemo drug, it is a targeted therapy anticancer drug.
Herceptin contains one active ingredient, trastuzumab, and is given as an intravenous (IV) infusion slowly into a vein. Herceptin Hylecta contains two active ingredients, trastuzumab and hyaluronidase-oysk, and is given as a subcutaneous injection, which is an injection that goes under the skin.

Mechanism of action

Trastuzumab is a monoclonal antibody against human epidermal growth factor receptor 2 (HER2). Trastuzumab binds to an extracellular domain of this receptor and inhibits HER2 homodimerization, thereby preventing HER2-mediated signaling. It is also thought to facilitate antibody-dependent cellular cytotoxicity, leading to the death of cells that express HER2. Its mechanism differs slightly from that of the newer agent pertuzumab; the latter inhibits hetero-dimerization of HER2 with HER3, a related growth factor receptor. Trastuzumab has been shown to bind three distinct regions of domain IV of the HER2 extracellular domain through electrostatic and hydrophobic bindings[1].

References

[1] Hamid Maadi. “Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma.” Cancers (2021).

Trastuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Trastuzumab manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Trastuzumab 180288-69-1
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-01-10
Dideu Industries Group Limited
Product
Trastuzumab 180288-69-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-02
Shaanxi Dideu Medichem Co. Ltd
Product
Trastuzumab 180288-69-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

180288-69-1, TrastuzumabRelated Search:


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