3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

Product Name: 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
CAS No.: 67-30-1
Chemical Name: 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
Synonyms: TETRAC;Tetrac, 10 mM in DMSO;tetraiodothyroaceticacid;Liothyronine EP Impurity D;Levothyroxine – Impurity D;Levothyroxine EP Impurity D;Linagliptin Impurity CD10097;Liothyronine Sodium Impurity D;3,5,3’,5’-tetraiodothyroacetique;Liothyronine Sodium EP Impurity D
CBNumber: CB6124010
Molecular Formula: C14H8I4O4
Formula Weight: 747.83
MOL File: 67-30-1.mol

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Property

Melting point:: 219-220 °C (decomp)
Boiling point:: 544.8±50.0 °C(Predicted)
Density: 2.727±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow)
form: powder to crystal
pka: 3.98±0.10(Predicted)
color: White to Yellow to Green
InChI: InChI=1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20)
InChIKey: PPJYSSNKSXAVDB-UHFFFAOYSA-N
SMILES: C1(CC(O)=O)=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1

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Safety

Hazard Codes: T+
Risk Statements: 28
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: CY1585800
HS Code: 2916.39.7900
HazardClass: 6.1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3787
Product name: 3,3′,5,5′-Tetraiodothyroacetic acid
Packaging: 25mg
Price: $134.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: T3787
Product name: 3,3′,5,5′-Tetraiodothyroacetic acid
Packaging: 100mg
Price: $420
Updated: 2025/07/31

TCI Chemical

Product number: T3730
Product name: 3,3',5,5'-Tetraiodothyroacetic Acid
Packaging: 100MG
Price: $229
Updated: 2025/07/31

TCI Chemical

Product number: T3730
Product name: 3,3',5,5'-Tetraiodothyroacetic Acid
Packaging: 500MG
Price: $695
Updated: 2025/07/31

TRC

Product number: T296125
Product name: 3,5,3'',5''-TetraiodoThyroaceticAcid
Packaging: 50mg
Price: $100
Updated: 2021/12/16

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Chemical Properties,Usage,Production

Uses

Thyroid hormone analogue

Uses

3,3′,5,5′-Tetraiodothyroacetic acid has been used:

as a positive control to study the effects of ioxynil (IOX)
diethylstilbestrol (DES) exposure on zebrafish embryos
to study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male rats
to determine its influence on the actions of thyroid-stimulating hormone
thyroid-stimulating immunoglobulins in orbital fibroblast

Definition

ChEBI: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.

Biochem/physiol Actions

Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1.

in vivo

Tetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice^[4].

Animal Model:	Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells^[4]
Dosage:	35 μg per day
Administration:	P.o. (added to the drinking water) daily for 40 days
Result:	Delayed the onset of ocular melanoma. Reduced the S-100 and integrin staining level in the B16F10 mice model.

3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Suppliers

Canada 1 China 101 India 6 Japan 1 Switzerland 1 United Kingdom 2 United States 7 Global 119

TCI Chemicals (India) Pvt. Ltd.

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Country: India
ProdList: 6768
Advantage: 58

SynZeal Research Pvt Ltd

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Email: standards@synzeal.com
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ProdList: 6514
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Pharmaffiliates Analytics and Synthetics P. Ltd

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ProdList: 6739
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View Lastest Price from 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID manufacturers

Moxin Chemicals

Product: Levothyroxine EP Impurity D 67-30-1
Price: US $0.00-0.00/mg
Min. Order: 30mg
Purity: 95
Supply Ability: 100000
Release date: 2025-02-14

Career Henan Chemical Co

Product: 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid 67-30-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

67-30-1, 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACIDRelated Search:

3,3',5-TRIIODOTHYROACETIC ACID 3,5-Diiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID REVERSE T3 N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde 3-IODO-L-TYROSINE 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetaMide 3,3',5-Triiodo-L-thyronine 3,5,3',5'-Tetraiodo Thyrolactic Acid 2',6'-Pipecoloxylidide 2-Piperidone 3,5-Diiodo-L-tyrosine dihydrate 3,4-Dimethoxy-L-phenylalanine Levothyroxine EP Impurity B Sodium levothyroxine

3,3’,5,5’-tetraiodo-thyroaceticaci

3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-benzeneaceticaci

3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneaceticacid

acide3,5,3’,5’-tetraiodothyroacetique

Levothyroxine – Impurity D

Liothyronine EP Impurity D

tetraiodothyroaceticacid

4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid

3,5-DIIODO-4-(4-HYDROXY-3,5-DIIODOPHENOXY)PHENYLACETIC ACID

4-[4-HYDROXY-3,5-DIIODOPHENOXY]-3,5-DIIODOBENZENEACETIC ACID

3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

[3,5-Diiodo-4-(3,5-diiodo-4-hydroxyphenoxy)phenyl]acetic acid

2-[3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid

3,5,3',5'-Tetraiodothyroacetic acid

4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid, Tetrac

Benzeneacetic acid,4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-

Levothyroxine EP Impurity D

TETRAC

(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-aceticaci

Levothyroxine Impurity 4（Levothyroxine EP Impurity D）

Levothyroxine impurity 14/Liothyronine EP Impurity D/2-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)acetic acid

Levothyroxine EP Impurity D/ T4-Acetic Acid (Liothyronine EP Impurity D/ Tetraiodothyroacetic Acid)

Liothyronine EP Impurity D (Tetraiodothyroacetic Acid/ Levothyroxine EP Impurity D/ T4-Acetic Acid)

3,5,3’,5’-tetraiodothyroacetique

Liothyronine Sodium Impurity D

Levothyroxine Sodium EP Impurity D

Liothyronine Sodium EP Impurity D

3，5，3’，5’-Tetraiodo Thyroacetic Acid

Linagliptin Impurity CD10097

LEVOTHYROXINE EP IMPURITY D | T4-ACETIC ACID (USP)

Levothyroxine EP Impurity-D (T4 acetic acid)

4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic Acid (Tetraiodothyroacetic Acid)

Tetrac, 10 mM in DMSO

67-30-1

1373321-04-1

1246812-40-8

C14H8I4O4

C14H8O4I4

Aromatic Phenylacetic Acids and Derivatives

Aromatics

Drug Analogues

Impurities

Intermediates & Fine Chemicals

Pharmaceuticals