Olesoxime

ChemicalBook > CAS DataBase List > Olesoxime

Product Name: Olesoxime
CAS No.: 22033-87-0
Chemical Name: Olesoxime
Synonyms: TRO19266;NSC 21311;olesoxime;TRO 19622;Olesoxime (TRO-19622);Cholest-4-en-3-one oxime;OLESOXIME;NSC 21311;TRO19622;TRO-19622;Cholest-4-en-3-one, oxime, NSC 21311;Inhibitor,NSC21311,NSC-21311,TRO19622,Olesoxime,inhibit,TRO-19622,Mitochondrial Metabolism;(NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
CBNumber: CB61254361
Molecular Formula: C27H45NO
Formula Weight: 399.65
MOL File: 22033-87-0.mol

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Olesoxime Property

Melting point:: 145-148 ºC
Boiling point:: 510.0±23.0 °C(Predicted)
Density: 1.10
storage temp.: -20°C
solubility: DMSO: >10mg/mL
form: solid
pka: 12.27±0.70(Predicted)
color: white
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 22033-87-0(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3077
Product name: TRO 19622
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: T3077
Product name: TRO 19622
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $528
Updated: 2024/03/01

Cayman Chemical

Product number: 21264
Product name: TRO 19622
Purity: ≥95% (mixture of isomers)
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 21264
Product name: TRO 19622
Purity: ≥95% (mixture of isomers)
Packaging: 50mg
Price: $543
Updated: 2024/03/01

Cayman Chemical

Product number: 21264
Product name: TRO 19622
Purity: ≥95% (mixture of isomers)
Packaging: 100mg
Price: $961
Updated: 2024/03/01

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Olesoxime Chemical Properties,Usage,Production

Description

TRO19622 (22033-87-0) is a neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1?Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2?Inhibits MPTP opening and protects neurons from apoptosis.3?Induces oligodendrocyte maturation in culture and promotes myelin regeneration?in vivo?in a rodent model.4

Uses

TRO 19622 interacts with mitochondria proteins and is able to promote neuron survival under stress conditions. It is a potential drug for treating amyotrophic lateral sclerosis (ALS). TRO 19622 is a neuroregenerative and neuroprotective agent. This is a research product for neuroscience.

Uses

TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons². TRO 19622 is also known to stimulate myelin repair in rat models of demyelination³.

Biological Activity

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo . Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein.

Biochem/physiol Actions

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.

storage

Desiccate at +4°C

References

1) Bordet?et al.?(2007),?Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther.,?322?709 2) Ma?et al.?(2014),?NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol.,?75?209 3) Martin?et al.?(2011),?The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci.,?31?359 4) Magalon?et al. (2016),?Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology,?111?293

Olesoxime Preparation Products And Raw materials

Raw materials

Preparation Products

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Olesoxime Suppliers

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22033-87-0, OlesoximeRelated Search:

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(NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine

olesoxime

Cholest-4-en-3-one, oxime, NSC 21311

TRO 19622

Cholest-4-en-3-one oxime

NSC 21311

TRO19266

OLESOXIME;NSC 21311;TRO19622;TRO-19622

(8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-((r)-6-methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime

Olesoxime (TRO-19622)

Inhibitor,NSC21311,NSC-21311,TRO19622,Olesoxime,inhibit,TRO-19622,Mitochondrial Metabolism

(8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one oxime

22033-87-0