ChemicalBook > CAS DataBase List > Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
- Product Name
- Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
- CAS No.
- 58168-20-0
- Chemical Name
- Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
- Synonyms
- strontium ranelate intermediate;StrontiuM ranelate interMediate I;5-amino-4-cyano-3-(2-ethoxy-2-oxoethyL;Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl);5-aMino-4-cyano-2-(ethoxycarbonyl)-ethyl ester;Ethyl 5-aMino-4-cyano-3-(2-ethoxy-2-oxoethyl)thioph;5-aMino-4-cyano-3-(2-B-cyano-2-carboxyMethyl)-2-thiophene Ethyl;5-aMino-4-cy ano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate;Ethyl5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carb...;Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxy
- CBNumber
- CB61462681
- Molecular Formula
- C12H14N2O4S
- Formula Weight
- 282.32
- MOL File
- 58168-20-0.mol
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Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate Property
- Melting point:
- 134-139 °C
- Boiling point:
- 469.6±45.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- powder to crystal
- pka
- -2.61±0.10(Predicted)
- color
- Light yellow to Yellow
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Safety
- HS Code
- 2934.99.4400
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- E0980
- Product name
- Ethyl 5-Amino-4-cyano-3-(2-ethoxycarbonylmethyl)thiophene-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E0980
- Product name
- Ethyl 5-Amino-4-cyano-3-(2-ethoxycarbonylmethyl)thiophene-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $67
- Updated
- 2025/07/31
TRC
- Product number
- E899440
- Product name
- Ethyl5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
AK Scientific
- Product number
- B524
- Product name
- Ethyl5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
- Packaging
- 5g
- Price
- $49
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0311751
- Product name
- 5-AMINO-4-CYANO-2-(ETHOXYCARBONYL)-3-THIOPHENEACETIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.38
- Updated
- 2021/12/16
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Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate Chemical Properties,Usage,Production
Synthesis
105-50-0
109-77-3
58168-20-0
Example 1: Preparation of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate (compound of formula II) 1. triethylamine (25 g) was added to a solution of ethanol (75 ml) containing malononitrile (16.33 g) at ambient temperature. 2. Diethyl 3-oxoglutarate (50 g) was added to the above solution, keeping the reaction mixture stirred at 40-45 °C for 1 hour. 3. Sulfur (7.9 g) was added to the reaction mixture and subsequently heated to reflux until the reaction was complete. 4. After completion of the reaction, the reaction material was cooled to ambient temperature and water (400 ml) was slowly added. 5. After stirring the reaction mixture for 1 hour, the product was collected by filtration, washed with water (200 ml) and dried at 40-50 °C. Yield: 82%.
References
[1] Heteroatom Chemistry, 2007, vol. 18, # 3, p. 236 - 238
[2] Patent: WO2013/113319, 2013, A1. Location in patent: Page/Page column 6
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate manufacturers
Career Henan Chemical Co
- Product
- Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate 58168-20-0
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-26
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