ChemicalBook > CAS DataBase List > 4-Methylbenzenesulfonhydrazide
4-Methylbenzenesulfonhydrazide
Uses- Product Name
- 4-Methylbenzenesulfonhydrazide
- CAS No.
- 1576-35-8
- Chemical Name
- 4-Methylbenzenesulfonhydrazide
- Synonyms
- TSH;P-TOLUENESULFONYL HYDRAZIDE;PTSH;TOSYLHYDRAZIDE;Tosylhydrazine;TOLUENE-4-SULFONIC ACID HYDRAZIDE;P-TOLUENESULFONHYDRAZIDE;P-TOLUENESULFONYLHYDRAZINE;Toluol-4-sulfonohydrazid;p-Toluenesulfonohydrazide
- CBNumber
- CB6156664
- Molecular Formula
- C7H10N2O2S
- Formula Weight
- 186.23
- MOL File
- 1576-35-8.mol
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4-Methylbenzenesulfonhydrazide Property
- Melting point:
- 103-108 °C(lit.)
- Boiling point:
- 340.5±35.0 °C(Predicted)
- Density
- 1.42g/cm3
- vapor pressure
- 0Pa at 20℃
- refractive index
- 1.5400 (estimate)
- Flash point:
- 60°C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- 5g/l
- form
- Powder
- pka
- 9.39±0.10(Predicted)
- color
- White or off-white to slightly grayish
- Water Solubility
- 5 g/L (15 ºC)
- Sensitive
- Moisture Sensitive
- BRN
- 610130
- Stability:
- Light Sensitive
- InChIKey
- ICGLPKIVTVWCFT-UHFFFAOYSA-N
- LogP
- 0.55 at 25℃
- CAS DataBase Reference
- 1576-35-8(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenesulfonic acid, 4-methyl-, hydrazide (1576-35-8)
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Safety
- Hazard Codes
- F,Xn
- Risk Statements
- 11-22-44-2017/11/22
- Safety Statements
- 16-26
- RIDADR
- UN 3226 4.1
- WGK Germany
- 3
- RTECS
- MW0210000
- TSCA
- Yes
- HazardClass
- 4.1
- PackingGroup
- II
- HS Code
- 29280090
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 132004
- Product name
- p-Toluenesulfonyl hydrazide
- Purity
- 97%
- Packaging
- 25g
- Price
- $56.6
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 132004
- Product name
- p-Toluenesulfonyl hydrazide
- Purity
- 97%
- Packaging
- 100g
- Price
- $108
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- RAB0502
- Product name
- Human Thyroid Stimulating Hormone ELISA Kit
- Purity
- for serum, plasma, cell culture supernatants and urine
- Packaging
- 1kit
- Price
- $569
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 132004
- Product name
- p-Toluenesulfonyl hydrazide
- Purity
- 97%
- Packaging
- 500g
- Price
- $229
- Updated
- 2025/07/31
TRC
- Product number
- T535925
- Product name
- p-Toluenesulfonyl hydrazide
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
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4-Methylbenzenesulfonhydrazide Chemical Properties,Usage,Production
Uses
p-Toluenesulfonyl Hydrazide is a reactant that has been used in the synthesis of paspaline.
Chemical Properties
white to off-white powder
Uses
4-Methylbenzenesulfonhydrazide was widely used reagent for the preparation of tosylhydrazones.
Application
p-Toluenesulfonyl hydrazide is used as a reagent for the preparation of tosylhydrazones. It was used to prepare dipyrazolo[1,5-a:4',3'-c]pyridines and 1,2,3-selenadiazole derivatives.
Reactions
4-Methylbenzenesulfonhydrazide as hydrogen donor in reduction reactions:
Flammability and Explosibility
Not classified
Synthesis
98-59-9
1576-35-8
General procedure for the synthesis of p-toluenesulfonyl hydrazide from p-toluenesulfonyl chloride: general method: preparation of p-toluenesulfonyl hydrazide. A mixed solution of water (300 mL) and hydrazine hydrate (12.5 g; 0.25 mol) was cooled to about 5 °C in an ice-water bath. The reaction temperature was kept below 8 °C while a tetrahydrofuran (50 mL) solution of p-toluenesulfonyl chloride (5.54 g, 0.025 mol) was slowly added under stirring. After the addition was completed, the reaction mixture was continued to be stirred at room temperature for 30 min. Subsequently, the tetrahydrofuran was removed by distillation under reduced pressure. The white solid product was isolated by filtration and washed with cold water (3 x 15 mL). Finally, the product was dried in air overnight to give pure p-toluenesulfonyl hydrazide (4.86 g; 89% yield).
Purification Methods
Dissolve the 4-Methylbenzenesulfonhydrazide in hot MeOH (~1g/4mL), filter through Celite and precipitate the material by adding 2-2.5 volumes of distilled H2O. Dry it in air or in a vacuum. [Fiedman et al. Org Synth Coll Vol V 1055 1973, Beilstein 11 II 66.]
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 17, p. 4629 - 4636
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3397 - 3407
[3] Archiv der Pharmazie, 2014, vol. 347, # 8, p. 576 - 588
[4] Patent: CN107056871, 2017, A. Location in patent: Paragraph 0022; 0030; 0038
[5] Journal of Molecular Structure, 2017, vol. 1133, p. 80 - 89
4-Methylbenzenesulfonhydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Methylbenzenesulfonhydrazide manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-Methylbenzenesulfonhydrazide 1576-35-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-20
Moxin Chemicals
- Product
- Anastrozole Impurity 1576-35-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98
- Supply Ability
- 10000000
- Release date
- 2025-02-22
Hebei Zhuanglai Chemical Trading Co.,Ltd
- Product
- 4-Methylbenzenesulfonhydrazide 1576-35-8
- Price
- US $99.00-35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-10
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