ChemicalBook > CAS DataBase List > 4-(Boc-amino)pyridine

4-(Boc-amino)pyridine

Product Name
4-(Boc-amino)pyridine
CAS No.
98400-69-2
Chemical Name
4-(Boc-amino)pyridine
Synonyms
4-(BOC-AMINO)PYRIDINE;N-BOC-4-AMINO-PYRIDINE;BOC-N-4-AMINO-PYRIDINE;Linagliptin Impurity 76;4-(Boc-amino)pyridine ,97%;tert-Butyl 4-pyridylcarbamate;N-(4-pyridyl) t-butyl carbamate;tert-Butyl N-(4-Pyridyl)carbamate;TERT-BUTYL (PYRIDIN-4-YL)CARBAMATE;tert-butyl N-(pyridin-4-yl)carbaMate
CBNumber
CB6176039
Molecular Formula
C10H14N2O2
Formula Weight
194.23
MOL File
98400-69-2.mol
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4-(Boc-amino)pyridine Property

Melting point:
145-149 °C
Boiling point:
252.7±13.0 °C(Predicted)
Density 
1.131±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
12?+-.0.70(Predicted)
color 
White to Almost white
InChI
InChI=1S/C10H14N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h4-7H,1-3H3,(H,11,12,13)
InChIKey
DRZYCRFOGWMEES-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NC1C=CN=CC=1
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Safety

Hazard Codes 
Xn
Risk Statements 
22-43
Safety Statements 
36/37
WGK Germany 
3
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3331
Product name
4-(tert-Butoxycarbonylamino)pyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$87
Updated
2025/07/31
TCI Chemical
Product number
B3331
Product name
4-(tert-Butoxycarbonylamino)pyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$323
Updated
2025/07/31
TRC
Product number
B621190
Product name
4-(Boc-amino)pyridine
Packaging
5g
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
075637
Product name
4-(Boc-amino)pyridine
Purity
95+%
Packaging
5g
Price
$22
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK178693
Product name
4-(Boc-amino)pyridine
Purity
97%
Packaging
1g
Price
$24
Updated
2021/12/16
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4-(Boc-amino)pyridine Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

4-(Boc-amino)pyridine is a protected derivative of the amino acid Pyridine, a heterocyclic compound that is commonly found in biological specimens (such as human red blood cells), and is used as a starting reagent and intermediate in the chemical and pharmaceutical industries.

Synthesis

504-24-5

24424-99-5

98400-69-2

At room temperature, 4-aminopyridine (600 mg, 6.36 mmol), 4-dimethylaminopyridine (DMAP, 600 μg, 5.00 μmol), di-tert-butyl dicarbonate (Boc2O, 1.57 mL, 7.00 mmol) and triethylamine (Et3N, 1 mL, 7.63 mmol) were suspended in anhydrous tetrahydrofuran (THF, 3 mL) in anhydrous tetrahydrofuran (THF, 3 mL) and the reaction was stirred under argon protection for 20 min. After completion of the reaction, the reaction mixture was diluted with dichloromethane (CH2Cl2, 5 mL) and washed with 0.1 N hydrochloric acid (5 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated by rotary evaporation. Finally, the target product 4-(tert-butoxycarbonylamino)pyridine (S1w, 1.30 g, yield >99%) was purified as a white solid by column chromatography (eluent ratio 30:1 dichloromethane/methanol).

References

[1] Tetrahedron Letters, 2006, vol. 47, # 7, p. 1087 - 1091
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 14, p. 2769 - 2771
[3] Chemistry Letters, 2010, vol. 39, # 11, p. 1127 - 1129
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 9, p. 2114 - 2124
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322

4-(Boc-amino)pyridine Preparation Products And Raw materials

Raw materials

Hexane Di-tert-butyl dicarbonate Potassium carbonate Triethylamine Ethyl acetate Hydrochloric acid Dichloromethane 4-Aminopyridine

Preparation Products

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4-(Boc-amino)pyridine Suppliers

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View Lastest Price from 4-(Boc-amino)pyridine manufacturers

Dideu Industries Group Limited
Product
4-(Boc-amino)pyridine 98400-69-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26
Career Henan Chemical Co
Product
4-(Boc-amino)pyridine 98400-69-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
g/kg/T
Release date
2019-12-18

98400-69-2, 4-(Boc-amino)pyridineRelated Search:

3-Aminopyridine Glycine tert-Butyl carbamate Methyl anthranilate Betaine 2-Aminopyridine Urethane Chromium picolinate 4-N-BOC-Aminopiperidine tert-Butyl carbazate ALTRENOGEST tert-Butyl glycinate tert-Butyl peroxybenzoate 4-Dimethylaminopyridine tert-Butyl 4-aminobenzoate Pyridine 4-Aminobenzoic acid tert-butyl thiazol-4-ylcarbamate

  • 4-(Boc-amino)pyridine tert-Butyl N-(4-Pyridyl)carbamate
  • Pyridin-4-yl-carbaMic acid tert-butyl ester
  • N-BOC-4-AMINO-PYRIDINE
  • TERT-BUTYL (PYRIDIN-4-YL)CARBAMATE
  • 4-(BOC-AMINO)PYRIDINE
  • 4-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
  • Carbamic acid, 4-pyridinyl-, 1,1-dimethylethyl ester (9CI)
  • BOC-N-4-AMINO-PYRIDINE
  • tert-butyl N-(pyridin-4-yl)carbaMate
  • 4-(Boc-amino)pyridine ,97%
  • 4-<N-(tert-butyloxycarbonyl)amino>pyridine
  • N-(4-pyridyl) t-butyl carbamate
  • 4-(tert-Butoxycarbonylamino)pyridine &gt
  • Carbamic acid, 4-pyridinyl-, 1,1-dimethylethyl ester
  • Carbamic acid, N-4-pyridinyl-, 1,1-dimethylethyl ester
  • tert-Butyl N-(4-Pyridyl)carbamate
  • 4-(Boc-amino)pyridine ISO 9001：2015 REACH
  • Linagliptin Impurity 76
  • tert-Butyl 4-pyridylcarbamate
  • 98400-69-2
  • Building Blocks
  • C9 to C46
  • Pyridines
  • Heterocyclic Building Blocks
  • CMLLYL
  • Heterocycles
  • Heterocyclic Compounds
  • N-BOC
  • Heterocycle-Pyridine series
  • amine