4-(Boc-amino)pyridine
- Product Name
- 4-(Boc-amino)pyridine
- CAS No.
- 98400-69-2
- Chemical Name
- 4-(Boc-amino)pyridine
- Synonyms
- 4-(BOC-AMINO)PYRIDINE;N-BOC-4-AMINO-PYRIDINE;BOC-N-4-AMINO-PYRIDINE;Linagliptin Impurity 76;4-(Boc-amino)pyridine ,97%;tert-Butyl 4-pyridylcarbamate;N-(4-pyridyl) t-butyl carbamate;tert-Butyl N-(4-Pyridyl)carbamate;TERT-BUTYL (PYRIDIN-4-YL)CARBAMATE;tert-butyl N-(pyridin-4-yl)carbaMate
- CBNumber
- CB6176039
- Molecular Formula
- C10H14N2O2
- Formula Weight
- 194.23
- MOL File
- 98400-69-2.mol
4-(Boc-amino)pyridine Property
- Melting point:
- 145-149 °C
- Boiling point:
- 252.7±13.0 °C(Predicted)
- Density
- 1.131±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 12?+-.0.70(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C10H14N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h4-7H,1-3H3,(H,11,12,13)
- InChIKey
- DRZYCRFOGWMEES-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1C=CN=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B3331
- Product name
- 4-(tert-Butoxycarbonylamino)pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $87
- Updated
- 2025/07/31
- Product number
- B3331
- Product name
- 4-(tert-Butoxycarbonylamino)pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $323
- Updated
- 2025/07/31
- Product number
- B621190
- Product name
- 4-(Boc-amino)pyridine
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 075637
- Product name
- 4-(Boc-amino)pyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- JK178693
- Product name
- 4-(Boc-amino)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
4-(Boc-amino)pyridine Chemical Properties,Usage,Production
Chemical Properties
White to light brown solid
Uses
4-(Boc-amino)pyridine is a protected derivative of the amino acid Pyridine, a heterocyclic compound that is commonly found in biological specimens (such as human red blood cells), and is used as a starting reagent and intermediate in the chemical and pharmaceutical industries.
Synthesis
504-24-5
24424-99-5
98400-69-2
At room temperature, 4-aminopyridine (600 mg, 6.36 mmol), 4-dimethylaminopyridine (DMAP, 600 μg, 5.00 μmol), di-tert-butyl dicarbonate (Boc2O, 1.57 mL, 7.00 mmol) and triethylamine (Et3N, 1 mL, 7.63 mmol) were suspended in anhydrous tetrahydrofuran (THF, 3 mL) in anhydrous tetrahydrofuran (THF, 3 mL) and the reaction was stirred under argon protection for 20 min. After completion of the reaction, the reaction mixture was diluted with dichloromethane (CH2Cl2, 5 mL) and washed with 0.1 N hydrochloric acid (5 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated by rotary evaporation. Finally, the target product 4-(tert-butoxycarbonylamino)pyridine (S1w, 1.30 g, yield >99%) was purified as a white solid by column chromatography (eluent ratio 30:1 dichloromethane/methanol).
References
[1] Tetrahedron Letters, 2006, vol. 47, # 7, p. 1087 - 1091
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 14, p. 2769 - 2771
[3] Chemistry Letters, 2010, vol. 39, # 11, p. 1127 - 1129
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 9, p. 2114 - 2124
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
4-(Boc-amino)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-(Boc-amino)pyridine Suppliers
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- +32 (0)37350701
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View Lastest Price from 4-(Boc-amino)pyridine manufacturers
- Product
- 4-(Boc-amino)pyridine 98400-69-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 4-(Boc-amino)pyridine 98400-69-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-18