5-Bromo-2-chloropyridine
- Product Name
- 5-Bromo-2-chloropyridine
- CAS No.
- 53939-30-3
- Chemical Name
- 5-Bromo-2-chloropyridine
- Synonyms
- N-methyl-1-(pyridin-3-yl)methanamine;CL025;2-CHLORO-5-BROMOPYRIDINE;5-BROMO-2-CHLOROPYRIDINE;3-Bromo-6-chloropyridine;2-cholro-5-broMopyridine;5-Bromo-2-chloro pyridne;5-bromo-2-chlorolpyridine;PYRIDINE, 5-BROMO-2-CHLORO-;2-chloro -5-pyridyl broMide
- CBNumber
- CB6177511
- Molecular Formula
- C5H3BrClN
- Formula Weight
- 192.44
- MOL File
- 53939-30-3.mol
5-Bromo-2-chloropyridine Property
- Melting point:
- 65-69 °C (lit.)
- Boiling point:
- 208.1±20.0 °C(Predicted)
- Density
- 1.7783 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -2.25±0.10(Predicted)
- form
- Crystalline Powder or Crystals
- color
- Off-white
- BRN
- 108887
- InChI
- InChI=1S/C5H3BrClN/c6-4-1-2-5(7)8-3-4/h1-3H
- InChIKey
- PEAOEIWYQVXZMB-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Br)C=C1
- CAS DataBase Reference
- 53939-30-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- T
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 551902
- Product name
- 5-Bromo-2-chloropyridine
- Purity
- 95%
- Packaging
- 25g
- Price
- $125
- Updated
- 2024/03/01
- Product number
- 551902
- Product name
- 5-Bromo-2-chloropyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $55.7
- Updated
- 2023/06/20
- Product number
- B2329
- Product name
- 5-Bromo-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $24
- Updated
- 2024/03/01
- Product number
- B2329
- Product name
- 5-Bromo-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $94
- Updated
- 2024/03/01
- Product number
- B24862
- Product name
- 5-Bromo-2-chloropyridine, 98%
- Packaging
- 5g
- Price
- $31.65
- Updated
- 2024/03/01
5-Bromo-2-chloropyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
5-Bromo-2-chloropyridine may be used in the preparation of following compounds:
- Amino-2-chloropyridine via palladium-catalyzed amination.
- 5-Bromo-2-fluoropyridine via halogen-exchange reaction using anhydrous potassium fluoride.
- 2-Chloro-5-(2,5-dimethoxyphenyl)pyridine via Suzuki coupling with 2,5-dimethoxyphenylboronic acid.
Synthesis
6-Chloro-pyridin-3-ylamine was dissolved slowly with constant stirring in 48% HBr solution (50 mL) at r.t. and then the solution was cooled to -10 °C. A solution of sodium nitrite in cold water was added dropwise at -10 °C with constant stirring over 2 h, followed by a solution of copper (I) bromide in 48% HBr dropwise. The mixture was then stirred at r.t. until complete. The mixture was neutralized with sodium carbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate, and concentrated. The residue was purified by column chromatography on silica gel (60-120 mesh) eluting with 1% ethyl acetate/petroleum ether to afford 5- bromo-2-chloropyridine.
5-Bromo-2-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2-chloropyridine Suppliers
View Lastest Price from 5-Bromo-2-chloropyridine manufacturers
- Product
- 2-Chloro-5-bromopyridine 53939-30-3
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Chloro-5-bromopyridine 53939-30-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-08
- Product
- 5-Bromo-2-chloropyridine 53939-30-3
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-09