ChemicalBook > CAS DataBase List > 2-Amino-4,5-dichloropyridine

2-Amino-4,5-dichloropyridine

Product Name
2-Amino-4,5-dichloropyridine
CAS No.
188577-68-6
Chemical Name
2-Amino-4,5-dichloropyridine
Synonyms
4,5-Dichloro-2-pyridinamine;4,5-dichloropyridin-2-amine;2-AMINO-4,5-DICHLOROPYRIDINE;2-Pyridinamine, 4,5-dichloro-;4,5-Dichloro-pyridin-2-ylamine;2-AMINO-4,5-DICHLOROPYRIDINE 97%;2-Pyridinamine,4,5-dichloro-(9CI);REF DUPL: 2-amino-4,5-dichloropyridine;188577-68-6;2-Amino-4,5-dichloropyridine ISO 9001:2015 REACH
CBNumber
CB6184700
Molecular Formula
C5H4Cl2N2
Formula Weight
163
MOL File
188577-68-6.mol
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2-Amino-4,5-dichloropyridine Property

Boiling point:
269.8±35.0 °C(Predicted)
Density 
1.497±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
3.63±0.24(Predicted)
form 
powder
color 
Red brown
InChI
InChI=1S/C5H4Cl2N2/c6-3-1-5(8)9-2-4(3)7/h1-2H,(H2,8,9)
InChIKey
CRRAQLWJVYODCL-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Cl)C(Cl)=C1
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Safety

Hazard Codes 
T
RIDADR 
UN2811
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHB00293
Product name
2-Amino-4,5-dichloropyridine
Purity
AldrichCPR
Packaging
1 g
Price
$107
Updated
2025/07/31
TRC
Product number
A596900
Product name
2-Amino-4,5-dichloropyridine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
A596900
Product name
2-Amino-4,5-dichloropyridine
Packaging
500mg
Price
$115
Updated
2021/12/16
Apolloscientific
Product number
OR59818
Product name
2-Amino-4,5-dichloropyridine
Packaging
250mg
Price
$27
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-Z6
Product name
2-Amino-4,5-dichloropyridine
Packaging
250mg
Price
$29
Updated
2021/12/16
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2-Amino-4,5-dichloropyridine Chemical Properties,Usage,Production

Synthesis

19798-80-2

188577-68-6

General procedure for the synthesis of 4,5-dichloropyridin-2-amine from 2-amino-4-chloropyridine: N-chlorosuccinimide (NCS, 2.67 g, 20.0 mmol) was added to a solution of 2-amino-4-chloropyridine (1.28 g, 10.0 mmol) in DMF (40 mL) at -20 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the mixture was poured into ice water (300 mL) and extracted with ethyl acetate. The combined organic phases were washed sequentially with 1 M sodium hydroxide solution and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford the target compound 4,5-dichloropyridin-2-amine (1.12 g, 69.0% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 60 - 67
[2] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 19 - 32
[3] Patent: WO2016/124553, 2016, A1. Location in patent: Page/Page column 71-72
[4] Patent: WO2018/11138, 2018, A1. Location in patent: Page/Page column 69-70
[5] Synthetic Communications, 1997, vol. 27, # 5, p. 861 - 870

2-Amino-4,5-dichloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-4,5-dichloropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-4,5-dichloropyridine 188577-68-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-06
Career Henan Chemical Co
Product
2-Amino-4,5-dichloropyridine 188577-68-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

188577-68-6, 2-Amino-4,5-dichloropyridineRelated Search:


  • 2-AMINO-4,5-DICHLOROPYRIDINE
  • 4,5-dichloropyridin-2-amine
  • 2-Pyridinamine,4,5-dichloro-(9CI)
  • 2-AMINO-4,5-DICHLOROPYRIDINE 97%
  • REF DUPL: 2-amino-4,5-dichloropyridine
  • 2-Pyridinamine, 4,5-dichloro-
  • 4,5-Dichloro-pyridin-2-ylamine
  • 4,5-Dichloro-2-pyridinamine
  • 2-Amino-4,5-dichloropyridine ISO 9001:2015 REACH
  • <font color="#ff0000">188577-68-6</font>
  • 188577-68-6
  • Pyridines
  • HALIDE