2-Amino-4,5-dichloropyridine
- Product Name
- 2-Amino-4,5-dichloropyridine
- CAS No.
- 188577-68-6
- Chemical Name
- 2-Amino-4,5-dichloropyridine
- Synonyms
- 4,5-Dichloro-2-pyridinamine;4,5-dichloropyridin-2-amine;2-AMINO-4,5-DICHLOROPYRIDINE;2-Pyridinamine, 4,5-dichloro-;4,5-Dichloro-pyridin-2-ylamine;2-AMINO-4,5-DICHLOROPYRIDINE 97%;2-Pyridinamine,4,5-dichloro-(9CI);REF DUPL: 2-amino-4,5-dichloropyridine;188577-68-6;2-Amino-4,5-dichloropyridine ISO 9001：2015 REACH
- CBNumber
- CB6184700
- Molecular Formula
- C5H4Cl2N2
- Formula Weight
- 163
- MOL File
- 188577-68-6.mol
2-Amino-4,5-dichloropyridine Property
- Boiling point:
- 269.8±35.0 °C(Predicted)
- Density
- 1.497±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.63±0.24(Predicted)
- form
- powder
- color
- Red brown
- InChI
- InChI=1S/C5H4Cl2N2/c6-3-1-5(8)9-2-4(3)7/h1-2H,(H2,8,9)
- InChIKey
- CRRAQLWJVYODCL-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Cl)C(Cl)=C1
Safety
- Hazard Codes
- T
- RIDADR
- UN2811
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHB00293
- Product name
- 2-Amino-4,5-dichloropyridine
- Purity
- AldrichCPR
- Packaging
- 1 g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- A596900
- Product name
- 2-Amino-4,5-dichloropyridine
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- A596900
- Product name
- 2-Amino-4,5-dichloropyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA148692
- Product name
- 2-Amino-4,5-dichloropyridine
- Packaging
- 250mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- OR59818
- Product name
- 2-Amino-4,5-dichloropyridine
- Packaging
- 250mg
- Price
- $27
- Updated
- 2021/12/16
2-Amino-4,5-dichloropyridine Chemical Properties,Usage,Production
Synthesis
19798-80-2
188577-68-6
General procedure for the synthesis of 4,5-dichloropyridin-2-amine from 2-amino-4-chloropyridine: N-chlorosuccinimide (NCS, 2.67 g, 20.0 mmol) was added to a solution of 2-amino-4-chloropyridine (1.28 g, 10.0 mmol) in DMF (40 mL) at -20 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the mixture was poured into ice water (300 mL) and extracted with ethyl acetate. The combined organic phases were washed sequentially with 1 M sodium hydroxide solution and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford the target compound 4,5-dichloropyridin-2-amine (1.12 g, 69.0% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 60 - 67
[2] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 19 - 32
[3] Patent: WO2016/124553, 2016, A1. Location in patent: Page/Page column 71-72
[4] Patent: WO2018/11138, 2018, A1. Location in patent: Page/Page column 69-70
[5] Synthetic Communications, 1997, vol. 27, # 5, p. 861 - 870
2-Amino-4,5-dichloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-4,5-dichloropyridine Suppliers
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- info@chemstep.com
- Country
- Europe
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View Lastest Price from 2-Amino-4,5-dichloropyridine manufacturers
- Product
- 2-Amino-4,5-dichloropyridine 188577-68-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-06
- Product
- 2-Amino-4,5-dichloropyridine 188577-68-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31