Pyrimidine
Six-membered heterocyclic compounds Chemical properties Uses Pyrimidine base The functions of purine, pyrimidine and other substances Preparation Fluorouracil- Product Name
- Pyrimidine
- CAS No.
- 289-95-2
- Chemical Name
- Pyrimidine
- Synonyms
- Pyrimidin;1,3-DIAZINE;Metadiazine;2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE;2,4,6-trichloro-5-formylpyrimidine;iazine;Miazine;m-Diazine;PYRIMIDINE;1,3-Diazin
- CBNumber
- CB6224079
- Molecular Formula
- C4H4N2
- Formula Weight
- 80.09
- MOL File
- 289-95-2.mol
Pyrimidine Property
- Melting point:
- 19-22 °C (lit.)
- Boiling point:
- 123-124 °C (lit.)
- Density
- 1.016 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.504(lit.)
- Flash point:
- 88 °F
- storage temp.
- Flammables area
- solubility
- soluble
- form
- Liquid
- pka
- 1.23(at 20℃)
- color
- Clear colorless to orange
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- Merck
- 14,7987
- BRN
- 103894
- Stability:
- Stable, but air-sensitive and hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Flammable.
- CAS DataBase Reference
- 289-95-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,3-Diazine(289-95-2)
- EPA Substance Registry System
- Pyrimidine (289-95-2)
Safety
- Risk Statements
- 10
- Safety Statements
- 23-24/25-16
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- RTECS
- UV6263000
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
N-Bromosuccinimide Price
- Product number
- 131695
- Product name
- Pyrimidine
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $45.8
- Updated
- 2024/03/01
- Product number
- 131695
- Product name
- Pyrimidine
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $124
- Updated
- 2024/03/01
- Product number
- P0662
- Product name
- Pyrimidine free base
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $33
- Updated
- 2024/03/01
- Product number
- P0662
- Product name
- Pyrimidine free base
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- A15534
- Product name
- Pyrimidine, 99%
- Packaging
- 1g
- Price
- $31.65
- Updated
- 2024/03/01
Pyrimidine Chemical Properties,Usage,Production
Six-membered heterocyclic compounds
Pyridine, also known as "metadiazine", is a six-membered heteroaromatic ring compound containing two nitrogen atoms in the meta-position, being isomers with pyridazine and pyrazine. It has a molecular formula of C4H4N2 with the molecular weight being 80.09. It appears as colorless liquid or solid crystals with a pungent odor. It has a melting temperature of 20~22 ℃, boiling point of 123~124 °C and refractive index of 1.4998 (20 °C). It is easily soluble in water, ethanol and ether with weak alkaline and being capable of forming salts with acid. Its alkalinity is weaker than pyridine. It is also more difficult for it to participate into electrophilic substitution reaction than pyridine. It can only undergo bromination at the 5th position and is not capable of having nitrification and sulfonation reaction, but more prone to participate into nucleophilic substitution. Pyrimidine derivatives are widely found in nature. For example, vitamin B1, uracil, cytosine and thymine all contain pyrimidine structure. Its picrate salt appears as yellow needle-like crystals. It has a melting temperature of 156 °C. Owing to the presence of conjugated double bonds in the structure, pyrimidine has strong absorption capability on ultraviolet light. It is manufactured through phosphorus oxychloride oxidation of barbituric acid, followed by reduction through hydrogen iodide.
Nucleic acid contains three important pyrimidine derivatives, being an important base in nucleic acid, plays an important role in the body of organisms.
DNA mainly contains cytosine and thymine while RNA mainly contains cytosine and uracil, in some nucleic acids, there are also small amount of pyrimidine modified base, for example:
Sulfadiazine and its derivatives are commonly used antibacterial anti-inflammatory drugs.
The above information is edited by Andy Edwards of Chemicalbook.
Chemical properties
It appears as colorless crystalline or liquid.
Uses
Pyrimidine is a heterocyclic organic molecule found in numerous pharmaceutical and naturally occurring compounds. It plays a significant role in the synthesis and discovery of antiviral medications, including those targeting HIV and HSV. Additionally, pyrimidine is involved in the synthesis of potent 15-lipoxygenase inhibitors that help reduce the release of leukotrienes. While pyrimidine itself has no direct applications, its derivatives, cytosine, uracil, and thymine, are essential components of nucleic acids. Various drugs, such as sulfadiazine, trimethoprim, and 6-mercaptopurine, also contain a pyrimidine ring.
Pyrimidine base
Pyrimidine base is one of the chemical compositions of the nucleotides. It consists of carbon, nitrogen, hydrogen, oxygen and other elements. Pyrimidine bases include uracil, cytosine, and thymine, where uracil and cytosine constitute the bases in ribonucleic acid molecules while thymine and cytosine constitute bases in deoxyribonucleic acid molecules. Pyrimidine base has a strong absorption on ultraviolet in the wavelength of 250~280nm. The raw materials for its synthesis are derived from carbamoyl phosphate and aspartic acid. Pyrimidine base can also be metabolized into carbon dioxide, β-alanine and β amino-isobutyric acid and other substances. Some patients, due to congenital factors or taking certain drugs, can get pyrimidine alkali metabolic disorders, causing whey aciduria.
The functions of purine, pyrimidine and other substances
Purines and pyrimidines are essential heterocyclic nitrogen-containing compounds that used in nucleic acid metabolism in organisms (including humans) and are important substances in the formation of ribonucleic acid and deoxyribonucleic acid in cells. Purine, pyrimidine and ribose and phosphate can combine to form RNA; purine, pyrimidine and deoxyribose can bind to phosphate to produce DNA. DNA is the main chemical constituent of genes, which plays an important role in the transmission of genes (genetics); the main function of RNA is the regulation of intracellular protein synthesis. The final product of purine metabolism is mainly uric acid. Barley and malt contains 0.2% to 0.3% of the dry matter of nucleic acid. Upon the saccharification, the dry matter of nucleic acid can be subject to the degradation of various phosphatases to form nucleotides, nucleosides, purines and pyrimidine and many other degradation products, of which only purine and pyrimidine can enter into yeast cells to constitute ribonucleic acid, deoxyribonucleic acid, adenosine triphosphate and some coenzymes. Nucleotides are difficult to be absorbed. If the medium is lack of purine and pyrimidine, the cells have to rely on carbohydrates and amino acids for synthesis, thus consuming a lot of energy and influence the proliferation of yeast. In general, wort is not lack of the required purine and pyrimidine.
References: Chinese Medical Encyclopedia Editorial Board Editor; Guo Di editor in chief. Chinese Encyclopedia of Medicine • fifty-seven pediatrics.
Preparation
1, take malondialdehyde and formamide as raw materials and have reaction upon heating; we can obtain pyrimidine.
2, it can be manufactured through the catalytic hydrogenation of 2, 4-dichloropyrimidine in the system.
3, use zinc powder to reduce 2, 4, 6-trichloropyrimidine, pyrimidine can be obtained.
4, the reaction between ethyl acetoacetate and amidine (below) can produce pyrimidine.
Fluorouracil
Fluorouracil is a pyrimidine antimetabolite. In the body, it is first converted into 5-fluoro-2-deoxyuridine nucleotides (FUdRP), causing inhibition of thymidylate synthase (TMPS), preventing the conversion of deoxyuridine nucleotide into thymidine, interfering with DNA synthesis and leading to cell damage and death. It has a stronger effect in the presence of leucovorin (CF) because FUdRP, FH4 and TMPS can form triple complexes making the active metabolite of drug bind more tightly with the enzyme, so addition of CF when applying will yield better efficacy, especially improving the efficacy upon being applied to colorectal cancer. This product is cell cycle-specific drugs with killing effects on proliferated cells at all stages. It is most sensitive to the S phase, and also has retardation effect on the G1/S border. Oral absorption is not complete, and the drug is easily inactivated upon liver metabolism. After intravenous infusion or arterial infusion, the blood concentration is relatively stable.
Fluorouracil has relative significant effect against choriocarcinoma and malignant mole. It also has certain curative effects on gastric cancer, colon cancer, rectum cancer, liver cancer, pancreatic cancer, breast cancer, ovarian cancer, cervical cancer, prostate cancer, bladder cancer, kidney cancer, lung cancer, head and neck cancer and skin cancer.
Chemical Properties
Colourless to pale yellow liquid
Uses
Pyrimidine is used as building block in chemical synthesis. Product Data Sheet
Uses
Pyrimidine was used to assess the extent of pyrimidine/purine asymmetry quantitatively. It was also used to study the photoinduced ion chemistry of the halogenated pyrimidines, a class of prototype radiosensitizing molecules.
Definition
ChEBI: Pyrimidine is a simple nitrogenous organic molecule whose ring structure is contained in the pyrimidine bases cytosine, thymine, and uracil, which are constituents of the nucleic acids. It has a role as a Daphnia magna metabolite. It is a member of pyrimidines and a diazine.
Pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
Pyrimidine Suppliers
- Tel
- 027-83313147 15307111131
- Fax
- 027-88716711
- hbxj6@xinjingchem.com
- Country
- China
- ProdList
- 28
- Advantage
- 58
- Tel
- 0319-5925599 13373390591
- 13373390591@163.com
- Country
- China
- ProdList
- 11427
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006608290; 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40241
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 0757-86329057 18501085097
- Fax
- 010-89508210
- sales3.gd@hwrkchemical.com
- Country
- China
- ProdList
- 7583
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12458
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
- Advantage
- 59
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 0712-0712-2580635 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 13355009207 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18739
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7815
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9823
- Advantage
- 79
- Tel
- +8618575662672 18575662672
- Fax
- 021 51613951
- mzeng@3wpharm.com
- Country
- China
- ProdList
- 9747
- Advantage
- 57
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11714
- Advantage
- 57
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 4974
- Advantage
- 50
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 0512-65617459 18915409046
- Fax
- 0512-65617459
- sales@sibian-chem.com
- Country
- China
- ProdList
- 1927
- Advantage
- 55
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17779
- Advantage
- 75
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6139
- Advantage
- 55
- Tel
- 021-50430803 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9352
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4576
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9906
- Advantage
- 55
- Tel
- +86 0510-85629785
- Fax
- +86 0510-85625359
- Country
- China
- ProdList
- 2331
- Advantage
- 58
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3933
- Advantage
- 58
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4928
- Advantage
- 55
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 021-58957966 18930537195
- Fax
- 021-60899437
- wouchina@126.com
- Country
- China
- ProdList
- 3033
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13358
- Advantage
- 58
- Tel
- 021-60899189-8001 18918189673
- Fax
- 021-60899304
- gtchem@126.com
- Country
- China
- ProdList
- 2661
- Advantage
- 58
- Tel
- 400-8592883 15367835770
- Fax
- 0731-82251112
- viola@huatengsci.com
- Country
- China
- ProdList
- 5877
- Advantage
- 58
- Tel
- 400-821-5857 021-64326257
- Fax
- 021-64393586 QQ;2798200800
- credit-chem@foxmail.com
- Country
- China
- ProdList
- 5223
- Advantage
- 58
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4951
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15878
- Advantage
- 55
- Tel
- 021-69106960 13701823733
- Fax
- 021-69106780
- 13701823733@163.com
- Country
- China
- ProdList
- 4775
- Advantage
- 60
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- 010-56218822 13717722232
- Fax
- 010-56218800
- xinsavichem@163.com
- Country
- China
- ProdList
- 3201
- Advantage
- 56
View Lastest Price from Pyrimidine manufacturers
- Product
- Pyrimidine 289-95-2
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- More than 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-04-29
- Product
- Pyrimidine 289-95-2
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- More than 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-04-18
- Product
- Pyrimidine 289-95-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000000
- Release date
- 2023-12-20