ChemicalBook > CAS DataBase List > Cyclobenzaprine hydrochloride

Cyclobenzaprine hydrochloride

Product Name
Cyclobenzaprine hydrochloride
CAS No.
6202-23-9
Chemical Name
Cyclobenzaprine hydrochloride
Synonyms
CYCLOBENZAPRINE HCL;flexeril;Flexiba;Lisseril;flexiban;Cyclobezaprine HCl;MK130 hydrochloride;Nortriptyline EP Impurity E;Amitriptyline EP Impurity B;Cyclobenzaprine HCl (MK130)
CBNumber
CB6238272
Molecular Formula
C20H22ClN
Formula Weight
311.85
MOL File
6202-23-9.mol
More
Less

Cyclobenzaprine hydrochloride Property

Melting point:
216-2180C
Flash point:
9℃
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Completely soluble in water
solubility 
≥15.59 mg/mL in DMSO; ≥5.32 mg/mL in EtOH; ≥54.3 mg/mL in H2O
form 
Solid
color 
White to Almost white
λmax
290nm(lit.)
Merck 
14,2713
InChIKey
VXEAYBOGHINOKW-UHFFFAOYSA-N
CAS DataBase Reference
6202-23-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,T,F
Risk Statements 
20/21/22-39/23/24/25-23/24/25-11
Safety Statements 
36-45-36/37-16-7
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
HP0875000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29214990
Toxicity
LD50 in mice (mg/kg): 35 i.v., 250 orally (Metysova)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C4542
Product name
Cyclobenzaprine hydrochloride
Packaging
1g
Price
$165
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2797
Product name
Cyclobenzaprine Hydrochloride
Purity
certified reference material, pharmaceutical secondary standard
Packaging
400MG
Price
$280
Updated
2024/03/01
Sigma-Aldrich
Product number
C-060
Product name
Cyclobenzaprine hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$38.1
Updated
2024/03/01
TCI Chemical
Product number
C3157
Product name
Cyclobenzaprine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
C3157
Product name
Cyclobenzaprine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$104
Updated
2024/03/01
More
Less

Cyclobenzaprine hydrochloride Chemical Properties,Usage,Production

Description

Cyclobenzaprine is a skeletal muscle relaxant that also has sedative properties. It has been shown to antagonize muscarinic receptors (Kis = 25, 60, and 6 nM for M1, M2, and M3, respectively), serotonin 5-HT2 receptors (Kis = 56 and 330 nM for 5-HT2C and 5-HT2B, respectively), and histamine H1 receptor (IC50 = 20 nM).

Chemical Properties

Crystalline Solid

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.

Uses

Cyclobenzaprine hydrochloride can be used as a serotonin receptor inhibitor.

Uses

Cyclobenzaprine hydrochloride cam be used as muscle relaxant (skeletal).

Definition

ChEBI: The hydrochloride salt of cyclobenzaprine. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

General Description

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of?noradrenaline. It is used to treat neck,?back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

References

[1]. honda m, nishida t, ono h. tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-ht2 receptors. european journal of pharmacology, 2003, 458(1): 91-99.
[2]. barnes c d, fung s j, gintautas j. brainstem noradrenergic system depression by cyclobenzaprine. neuropharmacology, 1980, 19(2): 221-224.
[3]. leysen j e. 5-ht2 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 11-26.

Cyclobenzaprine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Cyclobenzaprine hydrochloride Suppliers

Americas 1 Canada 3 China 177 Czech Republic 1 Europe 3 France 2 Germany 1 India 63 Italy 3 Japan 1 Malta 1 Norway 1 Philippines 1 Poland 1 Spain 3 Switzerland 4 United Arab Emirates 1 United Kingdom 13 United States 49 Venezuela 1 Global 330
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
ACIC FINE CHEMICALS INC
Tel
--
Fax
--
Email
sales@acic.com
Country
United States
ProdList
25
Advantage
58
Ceres Chemical Co., Inc.,
Tel
--
Fax
--
Country
United States
ProdList
14
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
ZETA Pharmaceuticals, L.L.C.
Tel
--
Fax
--
Email
zeta@zetapharm.com
Country
United States
ProdList
102
Advantage
58
Dipharma Inc
Tel
--
Fax
--
Country
United States
ProdList
5
Advantage
58
PlusPharma Incorporated
Tel
--
Fax
--
Email
info@pluspharm.com
Country
United States
ProdList
53
Advantage
58
American International Chemical LLC.
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
90
Advantage
58
Marla Chemical Company, LLC
Tel
--
Fax
--
Country
United States
ProdList
8
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Molcan Corporation
Tel
--
Fax
--
Email
info@molcan.com
Country
United States
ProdList
686
Advantage
60
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
CacheSyn Inc.
Tel
--
Fax
--
Email
info@cachesyn.com
Country
United States
ProdList
695
Advantage
50
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Cerilliant Corporation
Tel
--
Fax
--
Email
techserv@cerilliant.com
Country
United States
ProdList
1629
Advantage
69
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
ACIC Fine Chemicals Inc.
Tel
--
Fax
--
Email
sales@acic.com
Country
United States
ProdList
492
Advantage
48
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
794
Advantage
76
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@par-chem.com
Country
United States
ProdList
740
Advantage
66
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
More
Less

View Lastest Price from Cyclobenzaprine hydrochloride manufacturers

Guangzhou Tengyue Chemical Co., Ltd.
Product
Cyclobenzaprine hydrochloride 6202-23-9
Price
US $90.00/kg
Min. Order
1kg
Purity
99% Purity (What/sapp: +86 18145728414)
Supply Ability
1000 Tons/Month
Release date
2024-03-22
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
Product
Cyclobenzaprine hydrochloride;Cyclobenzaprine hcl 6202-23-9
Price
US $10.00/KG
Min. Order
10g
Purity
99%
Supply Ability
1000kg
Release date
2021-06-29
Career Henan Chemical Co
Product
Cyclobenzaprine hydrochloride 6202-23-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2018-08-08

6202-23-9, Cyclobenzaprine hydrochlorideRelated Search:

Aminoacetonitrile hydrochloride Phenformin hydrochloride 4-Dimethylaminobenzoic acid Gabapentin Topotecan hydrochloride Benzhexol hydrochloride 4-Dimethylaminobenzaldehyde D-Glucosamine hydrochloride 4-Dimethylaminopyridine Diphenhydramine Hydrochloride AMINOGUANIDINE HYDROCHLORIDE 3-Dimethylaminopropylamine CYCLOBENZAPRINE HCL 2-Dimethylaminoethanol Cycloheptatriene 10-hydroxyamitriptyline Desmethyl Cyclobenzaprine Hydrochloride AMITRIPTYLINE-D3 HCL (N-METHYL-D3)

  • 3-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanaminhydroc
  • 5-(3-dimethylaminopropylidene)-5h-dibenzo-(a,d)cycloheptenehydrochloride
  • CYCLOBENZAPRINEHYDROCHLORIDE,USP
  • Lisseril
  • Proheptatriene hydrochloride
  • Cyclobenzaprine hydrochloride,5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride
  • Cyclobenzaprine Hydrochloride (200 mg)
  • 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride
  • 1-PropanaMine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-diMethyl-, hydrochloride (1:1)
  • 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, hydrochloride (1:1)
  • Cyclobenzaprine hydrochloride solution
  • Cyclobenzaprine Hydrochloride(Flexeril,Yurelax)
  • Amitriptyline hydrochloride impurity B
  • Cyclobenzaprine Hydrochloride, Usp 99%
  • Cyclobenzaprine hydrochloride, 98%, a peripherally-acting AAAD or DOPA decarboxylase inhibitor
  • Amitriptyline EP Impurity B HCl
  • Nortriptyline EP Impurity E
  • Cyclobenzaprine (hydrochloride) (CRM)
  • Hydrochloride Cyclobenzaprine
  • MK130 hydrochloride
  • d)cycloheptene-delta(sup5)-gamma-propylamine,n,n-dimethyl-5h-dibenzo(hydr
  • flexeril
  • flexiban
  • n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5,gamma)-propylaminehydro
  • proheptatrienmonohydrochloride
  • CYCLOBENZAPRINE HCL
  • CYCLOBENZAPRINE HYDROCHLORIDE
  • AMITRITYLINE HYDROCHLORIDE IMP B
  • 5-[3-DIMETHYLAMINOPROPYLIDENE]-DIBENZO[A,E]CYCLOHEPTATRIENE HYDROCHLORIDE
  • 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride
  • 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine Hydrochloride
  • Flexiba
  • 1-Propanamine, 3-(5H-dibenzoa,dcyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
  • Amitriptyline EP Impurity B
  • Cyclobenzaprine hydrochloride CRS
  • Cyclobenzaprine Hydrochloride &gt
  • Amitriptyline EP Impurity B HCl (Nortriptyline EP Impurity E HCl)
  • Cyclobezaprine HCl
  • Amitriptyline EP Impurity B (Cyclobenzaprine)
  • Cyclobenzaprine HCl (MK130)
  • Cyclobenzaprine HydrochlorideQ: What is Cyclobenzaprine Hydrochloride Q: What is the CAS Number of Cyclobenzaprine Hydrochloride Q: What is the storage condition of Cyclobenzaprine Hydrochloride Q: What are the applications of Cyclobenzaprine Hydrochloride
  • Cyclobenzaprine Hydrochloride (1154503)
  • RSSYY(Perospirone Hydrochloride Hydrate)-1
  • Amitriptyline Hydrochloride EP Impurity B as Hydrochloride
  • Nortriptyline Hydrochloride EP Impurity E as Hydrochloride
  • Amitriptyline Hydrochloride Impurity B as Hydrochloride
  • Nortriptyline Hydrochloride Impurity E as Hydrochloride
  • Nortriptyline EP Impurity E HCl
  • Nortriptyline EP Impurity E HCl (Amitriptyline EP Impurity B HCl)
  • Cyclobenzaprine hydrochloride in methanol
  • Nortriptyline EP Impurity E (hydrochloride)
  • 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine Hydrochloride (Cyclobenzaprine Hy
  • 6202-23-9
  • 6202-32-9
  • C20H21NClH
  • C20H22ClN
  • C20H21NHCl
  • Skeletal muscle relaxant; reduces muscle spasm by depression of brainstem neurons; 5-HT2 serotonin receptor antagonist.