Phenanthridine
- Product Name
- Phenanthridine
- CAS No.
- 229-87-8
- Chemical Name
- Phenanthridine
- Synonyms
- PHENANTHRIDIN;9-Azaphenanthrene;5-azaphenanthrene;BENZO[C]QUINOLINE;3,4-BENZOQUINOLINE;3,4-Benzoisoquinoline;Phenathridine;PHENANTHRIDINE;6-Phenanthridine;Phenanthridine>
- CBNumber
- CB6239037
- Molecular Formula
- C13H9N
- Formula Weight
- 179.22
- MOL File
- 229-87-8.mol
Phenanthridine Property
- Melting point:
- 104-107 °C (lit.)
- Boiling point:
- 349 °C/769 mmHg (lit.)
- Density
- 1.1255 (rough estimate)
- refractive index
- 1.7270 (estimate)
- Flash point:
- 100 °C
- solubility
- phosphate buffer: soluble
- pka
- 5.58(at 20℃)
- form
- Powder
- color
- White to beige
- Water Solubility
- 0.3g/L(20 ºC)
- BRN
- 120204
- CAS DataBase Reference
- 229-87-8(CAS DataBase Reference)
- EPA Substance Registry System
- Phenanthridine (229-87-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- SF7928000
- HS Code
- 29333990
- Toxicity
- mic-bac-sat 50 mg/plate 50NNAZ7,73,83
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 157384
- Product name
- Phenanthridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $170
- Updated
- 2024/03/01
- Product number
- 262692
- Product name
- Phenanthridine
- Purity
- ≥99%, purified by sublimation
- Packaging
- 1g
- Price
- $105
- Updated
- 2023/01/07
- Product number
- P1047
- Product name
- Phenanthridine
- Purity
- >98.0%(GC)
- Packaging
- 10g
- Price
- $194
- Updated
- 2024/03/01
- Product number
- 77490
- Product name
- Phenanthridine
- Purity
- BioReagent, suitable for fluorescence, ≥98.0% (GC)
- Packaging
- 1g
- Price
- $85.9
- Updated
- 2021/12/16
- Product number
- P312653
- Product name
- Phenanthridine
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
Phenanthridine Chemical Properties,Usage,Production
Chemical Properties
white to beige powder
History
Phenanthridine was first discovered by Ame Pictet and H. J. Ankersmit in 1891 by pyrolysis of the condensed product of benzaldehyde and aniline. Earlier, phenanathridine and related compounds were prepared using mainly Pictect-Hurbert and modified Morgan-Walls type of condensation reactions.
Uses
Phenanthridine is an isomeric compound of acridine. It is a nitrogen heterocycle that is the basis of DNA-binding fluorescent dyes through intercalation. Ethidium bromide and propidium iodide are the examples of such intercalating dyes. It is used as a dye in biological and chemical sensors. It is also used in the study of ecotoxicity and rotational spectroscopic investigations and radio astronomical searches.
Definition
ChEBI: Phenanthridine is an azaarene that is the 9-aza derivative of phenanthrene. The parent of the class of phenanthridines. It is a mancude organic heterotricyclic parent, a polycyclic heteroarene, a member of phenanthridines and an azaarene.
Preparation
Palladium catalyzed synthesis of phenanthridine has been accomplished by Pritchard and coworkers from imidoyl selenides. This was the first report of palladium insertion into the C-Se bond. The palladium insertion into the imidoyl selenides 3.20 followed by intramolecular cyclization and subsequent aromatization via the elimination of HSePh lead to the formation of substituted phenanthridines 3.21.
Pd-catalysed synthesis of phenanathridine
Synthesis Reference(s)
Journal of the American Chemical Society, 74, p. 6295, 1952 DOI: 10.1021/ja01144a521
Journal of Heterocyclic Chemistry, 26, p. 865, 1989 DOI: 10.1002/jhet.5570260366
Tetrahedron Letters, 29, p. 5463, 1988 DOI: 10.1016/S0040-4039(00)80787-X
General Description
Phenanthridine appears as crystalline needles. Mutagenic.
Air & Water Reactions
Sparingly soluble in water.
Reactivity Profile
PHENANTHRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard
Flash point data are not available for PHENANTHRIDINE, but is probably combustible.
Safety Profile
Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
Phenanthridine Preparation Products And Raw materials
Raw materials
Preparation Products
Phenanthridine Suppliers
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- United Kingdom
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View Lastest Price from Phenanthridine manufacturers
- Product
- Phenanthridine 229-87-8
- Price
- US $2400.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-03-19
- Product
- PHENANTHRIDINE 229-87-8
- Price
- US $1.80/KG
- Min. Order
- 1g
- Purity
- 90.0%-99.9%
- Supply Ability
- 800kg
- Release date
- 2020-03-20