ChemicalBook > CAS DataBase List > 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID

Product Name
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
CAS No.
321674-73-1
Chemical Name
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
Synonyms
CS-1061;BIBR 1532;BIBR 1532, >=98%;BIBR 1532;BIBR-1532;Telomerase Inhibitor X;BIBR 1532, 10 mM in DMSO;(E)-2-(3-phenylbut-2-enamido)benzoic acid;2-[3-(NAPHTHALEN-2-YL)BUT-2-ENAMIDO]BENZOIC ACID;(E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid;2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid
CBNumber
CB62456353
Molecular Formula
C21H17NO3
Formula Weight
331.36
MOL File
321674-73-1.mol
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2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Property

Melting point:
>173oC (dec.)
Boiling point:
600.6±48.0 °C(Predicted)
Density 
1.284
storage temp. 
Store at RT
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
3.46±0.36(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.08839
Product name
Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem
Packaging
10mg
Price
$209
Updated
2024/03/01
Cayman Chemical
Product number
16608
Product name
BIBR 1532
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16608
Product name
BIBR 1532
Purity
≥95%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
16608
Product name
BIBR 1532
Purity
≥95%
Packaging
10mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
16608
Product name
BIBR 1532
Purity
≥95%
Packaging
50mg
Price
$517
Updated
2024/03/01
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2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Chemical Properties,Usage,Production

Description

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.

Uses

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.

Definition

ChEBI: 2-[[3-(2-naphthalenyl)-1-oxobut-2-enyl]amino]benzoic acid is an amidobenzoic acid.

Biological Activity

Selective telomerase inhibitor (IC 50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

storage

Store at RT

References

[1]. damm, k.; hemmann, u.; garin-chesa, p.; hauel, n.; kauffman, i.; priepke, h.; niestroj, c.; daiber, c.; enenkel, b.; guilliard, b.; lauritsch, i.; muller, e.; pascolo, e.; sauter, g.; pantic, m.; martens, u. m.; wenz, c.; linger, j.; kraut, n.; rettig, w. j.;schnapp, a. a highly selective telomerase inhibitor limiting human cancer cell proliferation. embo j. 2001, 20, 6958−6968.
[2]. bashash d1, ghaffari sh, mirzaee r, alimoghaddam k, ghavamzadeh a. telomerase inhibition by non-nucleosidic compound bibr1532 causes rapid cell death in pre-b acute lymphoblastic leukemia cells. leuk lymphoma. 2013 mar;54
[4]:561-8. doi: 10.3109/10428194.2012.704034. epub 2012 sep 28.
[3]. bashash d1, ghaffari sh, zaker f, kazerani m, hezave k, hassani s, rostami m, alimoghaddam k, ghavamzadeh a. anticancer agents med chem. 2013 sep;13(7):1115-25. bibr 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for apl.

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Suppliers

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View Lastest Price from 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID manufacturers

Career Henan Chemical Co
Product
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID 321674-73-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
as customer's need
Release date
2019-08-01

321674-73-1, 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACIDRelated Search:

COH-29 Bortezomib Daunorubicin hydrochloride Trametinib Entinostat Costunolide BEZ235 (NVP-BEZ235, Dactolisib) Upadacitinib Q-VD-OPh hydrate N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide H3B-6527 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Senexin B (S)-4-(4-((2-(3,5-diMethylphenyl)pyrrolidin-1-yl)Methyl)phenoxy)-3-fluorobenzaMide BMS-986205 Budiodarone tartrate 2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide BIBR 1532

  • CS-1061
  • 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
  • BIBR 1532
  • 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid
  • 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid
  • (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
  • (E)-2-(3-phenylbut-2-enamido)benzoic acid
  • BIBR 1532, >=98%
  • BIBR 1532;BIBR-1532
  • Benzoic acid, 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-
  • 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID USP/EP/BP
  • Telomerase Inhibitor X
  • 2-[3-(NAPHTHALEN-2-YL)BUT-2-ENAMIDO]BENZOIC ACID
  • BIBR 1532, 10 mM in DMSO
  • 321674-73-1
  • Inhibitors
  • API