TERT-BUTYL-N-METHYLCARBAMATE

Product Name: TERT-BUTYL-N-METHYLCARBAMATE
CAS No.: 16066-84-5
Chemical Name: TERT-BUTYL-N-METHYLCARBAMATE
Synonyms: tert-Butyl methylcarbamate;N-Boc-methanamine;TERT-BUTYL-N-METHYLCARB;ert-Butylmethylcarbamate;Methylamine, N-BOC protected;TERT-BUTYL-N-METHYLCARBAMATE;(tert-Butoxycarbonyl)methylamine;N-(tert-Butoxycarbonyl)methylamine;1,1-Dimethylethyl N-methylcarbamate;Methyl-carbaMic acid tert-butyl ester
CBNumber: CB62459248
Molecular Formula: C6H13NO2
Formula Weight: 131.17
MOL File: 16066-84-5.mol

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TERT-BUTYL-N-METHYLCARBAMATE Property

Boiling point:: 176.6±8.0 °C(Predicted)
Density: 0.937±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DCM, Methanol
form: Oil
pka: 13.04±0.46(Predicted)
color: Clear
InChI: InChI=1S/C6H13NO2/c1-6(2,3)9-5(8)7-4/h1-4H3,(H,7,8)
InChIKey: JHLVEBNWCCKSGY-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00012
Product name: tert-Butyl-N-methylcarbamate
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: B694020
Product name: tert-ButylMethylcarbamate
Packaging: 10g
Price: $345
Updated: 2021/12/16

Usbiological

Product number: 467175
Product name: tert-Butyl Methylcarbamate
Packaging: 250mg
Price: $355
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4156-1-36
Product name: tert-Butyl methylcarbamate
Purity: 95%
Packaging: 100g
Price: $359
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0118896
Product name: TERT-BUTYL-N-METHYLCARBAMATE
Purity: 95.00%
Packaging: 1G
Price: $634.25
Updated: 2021/12/16

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TERT-BUTYL-N-METHYLCARBAMATE Chemical Properties,Usage,Production

Uses

tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).

Synthesis

24424-99-5

74-89-5

16066-84-5

General method: Di-tert-butyl dicarbonate ((Boc)2O, 1.0 mmol) was mixed with monomethylamine (1.0 mmol) and the reaction was carried out with stirring at room temperature for the reaction time as shown in Table 1.The progress of the reaction was monitored by thin layer chromatography (TLC). In most cases, the purity of the resulting Boc-protected tert-butyl methyl-carbamate was satisfactory and no further purification was required. In a few cases, the products needed to be purified by silica gel column chromatography (eluent ratio: ethyl acetate/petroleum ether = 1:2). All products were characterized by infrared spectroscopy (IR), nuclear magnetic resonance hydrogen spectroscopy (1H NMR) and their physical properties.

References

[1] Tetrahedron Letters, 2009, vol. 50, # 46, p. 6244 - 6246
[2] Journal of Organic Chemistry, 2016, vol. 81, # 11, p. 4566 - 4575
[3] Letters in Organic Chemistry, 2013, vol. 10, # 2, p. 121 - 125
[4] Patent: WO2008/33567, 2008, A1. Location in patent: Page/Page column 41
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 1994, vol. 34, # 2, p. 107 - 115

TERT-BUTYL-N-METHYLCARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL-N-METHYLCARBAMATE Suppliers

China 134 India 3 Switzerland 1 United Kingdom 1 United States 10 Global 149

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Energy Chemical

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Jia Xing Isenchem Co.,Ltd

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View Lastest Price from TERT-BUTYL-N-METHYLCARBAMATE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: TERT-BUTYL-N-METHYLCARBAMATE 16066-84-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-09-09

Career Henan Chemical Co

Product: TERT-BUTYL-N-METHYLCARBAMATE 16066-84-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 96%
Supply Ability: 500kg
Release date: 2018-08-20

16066-84-5, TERT-BUTYL-N-METHYLCARBAMATERelated Search:

tert-Butyl N-hydroxycarbamate tert-Butyl N-(4-aminobutyl)carbamate TERT-BUTYL (3AR,6AS)-4-OXOHEXAHYDROCYCLOPENTA[C]PYRROLE-2(1H)-CARBOXYLATE(WX112238) (R)-tert-Butyl but-3-yn-2-ylcarbamate TETRAHYDRO-PYRAN-3-CARBALDEHYDE N/A TERT-BUTYL PIVALOYLACETATE TERT-BUTYL PENTANOYLACETATE N-(tert-Butoxycarbonyl)-L-phenylalanine H-Lys(Boc)-OH Boc-O-(2-bromo-Cbz)-L-Tyrosine BOC-Glycine BOC-L-Serine N-(tert-Butoxycarbonyl)-L-alanine BOC-TRP-OSU Fmoc-Lys(Boc)-OH BOC-L-Tyrosine BOC-N-Methyl-L-alanine

TERT-BUTYL-N-METHYLCARBAMATE

Methylamine, N-BOC protected

tert-Butyl methylcarbamate

Methyl-carbaMic acid tert-butyl ester

CarbaMic acid, Methyl-, 1,1-diMethylethyl ester

(tert-Butoxycarbonyl)methylamine

N-(tert-Butoxycarbonyl)methylamine

N-Methylcarbamic acid tert-butyl ester

N-Boc-methanamine

Carbamic acid, N-methyl-, 1,1-dimethylethyl ester

ert-Butylmethylcarbamate

1,1-Dimethylethyl N-methylcarbamate

TERT-BUTYL-N-METHYLCARB

tert-Butyl-N-methylcarbamate - [B2974]

16066-84-5

16066-84-6