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4-Methyl Erlotinib Hydrochloride

Product Name
4-Methyl Erlotinib Hydrochloride
CAS No.
1346601-52-2
Chemical Name
4-Methyl Erlotinib Hydrochloride
Synonyms
OSI-597;Erlotinib-9;4-methyl Erlotinib;Erlotinib iMpurity G;Erlotinib impurities406;Erlotinib 4-Methyl Analog;4-Methyl Erlotinib Hydrochloride;Azilsartan medoxomil impurity248;Erlotinib Hydrochloride iMpurity 8;N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
CBNumber
CB62544810
Molecular Formula
C23H25N3O4
Formula Weight
407.46
MOL File
1346601-52-2.mol
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4-Methyl Erlotinib Hydrochloride Property

Melting point:
224-228°C (dec.)
Boiling point:
567.5±50.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO, Methanol (Slightly)
pka
5.33±0.30(Predicted)
form 
Solid
color 
Pale Pink to Pale Brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
9001510
Product name
4-methyl Erlotinib
Purity
≥95%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
9001510
Product name
4-methyl Erlotinib
Purity
≥95%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
9001510
Product name
4-methyl Erlotinib
Purity
≥95%
Packaging
10mg
Price
$632
Updated
2024/03/01
TRC
Product number
M304630
Product name
4-MethylErlotinibHydrochloride
Packaging
5mg
Price
$245
Updated
2021/12/16
TRC
Product number
M304630
Product name
4-MethylErlotinibHydrochloride
Packaging
50mg
Price
$1940
Updated
2021/12/16
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4-Methyl Erlotinib Hydrochloride Chemical Properties,Usage,Production

Uses

Erlotinib (E625000) derivative as internal standard for HPLC.

Biological Activity

4-methyl erlotinib is an analog of erlotinib by the addition of a methyl group at the four position of the phenyl group. erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (egfr) [1].the epidermal growth factor receptor (egfr) autocrine pathway has been important for cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread [2].erlotinib inhibits egfr-associated kinase activity by binding to the egf-activated receptor, with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent [1].erlotinib can prolong survival in patients with non–small-cell lung cancer after first-line or second-line chemotherapy [3].

References

[1] stamos, j. ,sliwkowski, m.x. and eigenbrot, c. structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. the journal of biological chemisty 277(48), 46265-46272 (2002).
[2] ciardiello f, tortora g. a novel approach in the treatment of cancer: targeting the epidermal growth factor receptor[j]. clinical cancer research, 2001, 7(10): 2958-2970.
[3] shepherd f a, rodrigues pereira j, ciuleanu t, et al. erlotinib in previously treated non–small-cell lung cancer[j]. new england journal of medicine, 2005, 353(2): 123-132.

4-Methyl Erlotinib Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methyl Erlotinib Hydrochloride Suppliers

Canada 1 China 40 India 2 United States 3 Global 46
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1346601-52-2, 4-Methyl Erlotinib HydrochlorideRelated Search:

Erlotinib iMpurity 2 Erlotinib iMpurity 3 2,3,5-Trimethylpyridine-1-Oxide Ethyl 3,4-dihydroxybenzoate 3-Ethynylaniline 6,7-bis(2-methoxyethoxy)-N-phenylquinazolin-4-amine Erlotinib iMpurity 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline Erlotinib hydrochloride Desmethyl Erlotinib Acetate OSI-420 Erlotinib Erlotinib Impurity 20 4-Quinazolinamine,N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride(1:1) Erlotinib Erlotinib D6 HCl Didesmethyl Erlotinib Hydrochloride Salt

  • N-[(3-Ethynyl-4-Methyl)phenyl]-6,7-bis(2-Methoxyethoxy)-4-quinazolinaMine Hydrochloride
  • OSI-597
  • Erlotinib iMpurity G
  • N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
  • 4-Methyl Erlotinib Hydrochloride
  • N-(3-ETHYNYL-4-METHYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4-AMINE HCL
  • 4-methyl Erlotinib
  • Erlotinib 4-Methyl Analog
  • N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
  • Erlotinib-9
  • Erlotinib Hydrochloride iMpurity 8
  • N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quizolin-4-aminehydrochloride
  • Erlotinib impurity 15/N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
  • 4-Quinazolinamine, N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)-
  • N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
  • Azilsartan medoxomil impurity248
  • Erlotinib impurities406
  • Erlotinib impurity GQ: What is Erlotinib impurity G Q: What is the CAS Number of Erlotinib impurity G Q: What is the storage condition of Erlotinib impurity G
  • 1346601-52-2
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals