ChemicalBook > CAS DataBase List > 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid

5,8,11,14-Tetraoxa-2-azahexadecanedioic acid

Product Name
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
CAS No.
437655-95-3
Chemical Name
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
Synonyms
Fmoc-PEG4- CH2COOH;Fmoc-NH-PEG5-CH2CO2H;FMoc-NH-PEG4-CH2COOH;Fmoc-NH-PEG4-CH2CO2H;Fmoc-PEG4-acetic acid;Fmoc-N-Amido-PEG4-CH2COOH;5,8,11,14-Tetraoxa-2-azahexadecanedioic acid;1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid;14-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid
CBNumber
CB62546849
Molecular Formula
C25H31NO8
Formula Weight
473.52
MOL File
437655-95-3.mol
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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Property

Melting point:
51℃
Boiling point:
681.3±55.0 °C(Predicted)
Density 
1.235±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Oil
pka
3.39±0.10(Predicted)
color 
Colorless to light yellow
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Safety

HS Code 
2942000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0105401
Product name
Fmoc-NH-PEG4-CH2COOH
Packaging
250mg
Price
$100
Updated
2021/12/16
Activate Scientific
Product number
AS110733
Product name
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
Purity
97%
Packaging
250mg
Price
$174
Updated
2021/12/16
ChemScene
Product number
CS-0105401
Product name
Fmoc-NH-PEG4-CH2COOH
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0105401
Product name
Fmoc-NH-PEG4-CH2COOH
Packaging
1g
Price
$255
Updated
2021/12/16
chempep
Product number
280117
Product name
Fmoc-NH-PEG4-CH2COOH
Purity
>=95%
Packaging
1g
Price
$287
Updated
2021/12/16
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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Fmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

Cleavable

Alkyl/ether

PEGs

5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Suppliers

China 104 India 1 Japan 1 United Kingdom 1 United States 12 Global 119
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid manufacturers

Career Henan Chemical Co
Product
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 437655-95-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-03

437655-95-3, 5,8,11,14-Tetraoxa-2-azahexadecanedioic acidRelated Search:

N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE Succinimidyl 6-(biotinamido)hexanoate 2-[2-(2-methoxyethoxy)ethoxy]ethylamine H2N-PEG4-tBu OCTAETHYLENE GLYCOL MONOMETHYL ETHER 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE Maleimide-PEG4-NHS Ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol) Hexaethylene glycol 2,5,8,11-TETRAOXATRIDECANE-13-THIOL FMoc-NH-5(ethylene glycol)-acetic acid HO-PEG12-tBu N3-PEG4-tBu HEPTAETHYLENE GLYCOL MONOMETHYL ETHER FmocNH-PEG4-t-butyl acetate FmocNH-PEG5-t-butly ester FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID

  • 1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid
  • Fmoc-NH-PEG5-CH2CO2H
  • 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
  • FMoc-NH-PEG4-CH2COOH
  • 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
  • Fmoc-NH-PEG4-CH2CO2H
  • Fmoc-PEG4- CH2COOH
  • 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
  • Fmoc-PEG4-acetic acid
  • [2-(2-{2-[2-((9H-fluoren-9-yl-methoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid
  • 14-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,6,9,12-tetraoxatetradecanoic acid
  • 14-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid
  • Fmoc-N-Amido-PEG4-CH2COOH
  • FmocNH-PEG4-CH2COOH/5,8,11,14-Tetraoxa-2-azahexadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
  • 2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
  • 437655-95-3
  • peg