5,8,11,14-Tetraoxa-2-azahexadecanedioic acid

Product Name: 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
CAS No.: 437655-95-3
Chemical Name: 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
Synonyms: Fmoc-PEG4- CH2COOH;Fmoc-NH-PEG5-CH2CO2H;FMoc-NH-PEG4-CH2COOH;Fmoc-NH-PEG4-CH2CO2H;Fmoc-PEG4-acetic acid;Fmoc-N-Amido-PEG4-CH2COOH;5,8,11,14-Tetraoxa-2-azahexadecanedioic acid;1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid;14-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid
CBNumber: CB62546849
Molecular Formula: C25H31NO8
Formula Weight: 473.52
MOL File: 437655-95-3.mol

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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Property

Melting point:: 51℃
Boiling point:: 681.3±55.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: Oil
pka: 3.39±0.10(Predicted)
color: Colorless to light yellow

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Safety

HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0105401
Product name: Fmoc-NH-PEG4-CH2COOH
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Activate Scientific

Product number: AS110733
Product name: 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
Purity: 97%
Packaging: 250mg
Price: $174
Updated: 2021/12/16

ChemScene

Product number: CS-0105401
Product name: Fmoc-NH-PEG4-CH2COOH
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0105401
Product name: Fmoc-NH-PEG4-CH2COOH
Packaging: 1g
Price: $255
Updated: 2021/12/16

chempep

Product number: 280117
Product name: Fmoc-NH-PEG4-CH2COOH
Purity: >=95%
Packaging: 1g
Price: $287
Updated: 2021/12/16

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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Fmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

Cleavable

Alkyl/ether

PEGs

5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Suppliers

China 104 India 1 Japan 1 United Kingdom 1 United States 12 Global 119

ChemPep, Inc.

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PurePEG，LLC

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View Lastest Price from 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid manufacturers

Career Henan Chemical Co

Product: 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 437655-95-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-03

437655-95-3, 5,8,11,14-Tetraoxa-2-azahexadecanedioic acidRelated Search:

N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE Succinimidyl 6-(biotinamido)hexanoate 2-[2-(2-methoxyethoxy)ethoxy]ethylamine H2N-PEG4-tBu OCTAETHYLENE GLYCOL MONOMETHYL ETHER 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE Maleimide-PEG4-NHS Ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol) Hexaethylene glycol 2,5,8,11-TETRAOXATRIDECANE-13-THIOL FMoc-NH-5(ethylene glycol)-acetic acid HO-PEG12-tBu N3-PEG4-tBu HEPTAETHYLENE GLYCOL MONOMETHYL ETHER FmocNH-PEG4-t-butyl acetate FmocNH-PEG5-t-butly ester FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID

1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid

Fmoc-NH-PEG5-CH2CO2H

5,8,11,14-Tetraoxa-2-azahexadecanedioic acid

FMoc-NH-PEG4-CH2COOH

5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester

Fmoc-NH-PEG4-CH2CO2H

Fmoc-PEG4- CH2COOH

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid

Fmoc-PEG4-acetic acid

[2-(2-{2-[2-((9H-fluoren-9-yl-methoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid

14-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,6,9,12-tetraoxatetradecanoic acid

14-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid

Fmoc-N-Amido-PEG4-CH2COOH

FmocNH-PEG4-CH2COOH/5,8,11,14-Tetraoxa-2-azahexadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester

2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

437655-95-3

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