Wnt-C59

Product Name: Wnt-C59
CAS No.: 1243243-89-1
Chemical Name: Wnt-C59
Synonyms: C59;CS-876;Wnt-C59;Wnt-C59 (C59);Wnt-C59, >=98%;Wnt-C59 USP/EP/BP;WNT C59; C59;WNTC59;Wnt-C59, 10 mM in DMSO;WNT-C59 (C59);WNT C59;C59;C59, Wnt Antagonist, Wnt signaling pathway inhibitor
CBNumber: CB62645245
Molecular Formula: C25H21N3O
Formula Weight: 379.45
MOL File: 1243243-89-1.mol

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Wnt-C59 Property

Melting point:: >159°C (dec.)
Boiling point:: 628.3±55.0 °C(Predicted)
Density: 1.198±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form: Off-white powder
pka: 13.78±0.70(Predicted)
color: Tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.00496
Product name: Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
Packaging: 10MG
Price: $191
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 50mg
Price: $723
Updated: 2024/03/01

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Wnt-C59 Chemical Properties,Usage,Production

Description

Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4

Uses

Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.

storage

-20°C

References

1) Proffitt et al. (2013), Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of Wnt-Driven Mammary Cancer; Cancer Res., 73 502 2) Koo et al. (2015), Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia; Proc. Natl. Acad. Sci.USA, 112 7548 3) Motono et al. (2016), Wnt-C59, a Small-Molecule Wnt Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells; Stem Cells Transl.Med., 5 552 4) Madan et al. (2016), Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis; Kidney Int., 89 1062

Wnt-C59 Preparation Products And Raw materials

Raw materials

Preparation Products

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Wnt-C59 Suppliers

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MedChemexpress LLC

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1243243-89-1, Wnt-C59Related Search:

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Wnt-C59

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide

C59

Wnt-C59 (C59)

4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide

4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59

Wnt-C59, >=98%

WNT-C59 (C59);WNT C59;C59

2-[4-(2-Methyl-4-pyridyl)phenyl]-N-[4-(3-pyridyl)phenyl]acetamide

Wnt-C59, 98%, a potent PORCN enzymatic activity and Wnt inhibitor

CS-876

WNT C59; C59;WNTC59

Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem

Benzeneacetamide, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-

Wnt-C59 USP/EP/BP

C59, Wnt Antagonist, Wnt signaling pathway inhibitor

Wnt-C59, 10 mM in DMSO

1243243-89-1

Inhibitors

API