2-Chloro-6-methylnicotinic acid
- Product Name
- 2-Chloro-6-methylnicotinic acid
- CAS No.
- 30529-70-5
- Chemical Name
- 2-Chloro-6-methylnicotinic acid
- Synonyms
- 4-Chloro-6-methylnicotinic acid;3-Pyridinecarboxylic acid, 2-chloro-6-methyl-;TIMTEC-BB SBB003843;RARECHEM AL BO 0683;2-CHLORO-6-METHYLNICOTINIC ACID;6-METHYL-2-CHLORO NICOTINIC ACID;2-Chlroro-6-Methylnicotinic Acid;2-Chloro-6-methylnicotinicacid,97%;2-Chloro-6-methylnicotinic acid 98%;3-CARBOXY-2-CHLORO-6-METHYLPYRIDINE
- CBNumber
- CB6267128
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 30529-70-5.mol
2-Chloro-6-methylnicotinic acid Property
- Melting point:
- 162-164 °C (lit.)
- Boiling point:
- 163 °C / 22mmHg
- Density
- 1.3246 (rough estimate)
- refractive index
- 1.5560 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Crystalline Powder
- pka
- 2.28±0.28(Predicted)
- color
- White to yellow to beige
- BRN
- 473070
- InChI
- InChI=1S/C7H6ClNO2/c1-4-2-3-5(7(10)11)6(8)9-4/h2-3H,1H3,(H,10,11)
- InChIKey
- ACQXHCHKMFYDPM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(C)=CC=C1C(O)=O
- CAS DataBase Reference
- 30529-70-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 357847
- Product name
- 2-Chloro-6-methylpyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $94.5
- Updated
- 2022/05/15
- Product number
- C1762
- Product name
- 2-Chloro-6-methylnicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $94
- Updated
- 2025/07/31
- Product number
- C1762
- Product name
- 2-Chloro-6-methylnicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $376
- Updated
- 2025/07/31
- Product number
- C587623
- Product name
- 2-Chloro-6-methylnicotinic Acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C587623
- Product name
- 2-Chloro-6-methylnicotinic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
2-Chloro-6-methylnicotinic acid Chemical Properties,Usage,Production
Chemical Properties
white to yellow crystalline powder
Uses
2-Chloro-6-methylpyridine-3-carboxylic acid (2-Chloro-6-methylnicotinic acid) may be used in the synthesis of 6-methyl-2-thiophenoxynicotinic acid, required for the preparation of europium complex for staining the nucleolus of NIH 3T3, HeLa and HDF cells.
General Description
2-Chloro-6-methylpyridine-3-carboxylic acid (2-Chloro-6-methylnicotinic acid) is a nicotinic acid derivative.
Synthesis
28900-10-9
30529-70-5
General procedure for the synthesis of 2-chloro-6-methylnicotinic acid from 2-chloro-6-methyl-3-pyridinecarbonitrile: First, 2-chloro-3-cyano-6-methylpyridine (3.05 g) was dissolved in 75% sulfuric acid (10 mL). The reaction mixture was stirred at 110 °C for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly added dropwise to ice water. After stirring the ice-water mixture for 10 minutes, the precipitated crystals were collected by filtration and dried to give 2.91 g of 2-chloro-6-methylnicotinic acid in 85% yield. Next, the resulting 2-chloro-6-methylnicotinic acid (2.91 g) was mixed with 28% aqueous ammonia solution (35 mL) and placed in an autoclave and reacted at 170 °C for 40 hours. At the end of the reaction, the reaction solution was cooled to room temperature and the ammonia was removed by distillation under reduced pressure. The precipitated crystals were collected by filtration, washed with water and air-dried to give 1.91 g of amino-6-methylnicotinic acid in 74% yield. The total yield of the whole synthesis process was 62.9%.
References
[1] Patent: TW2016/509, 2016, A. Location in patent: Page/Page column 6
2-Chloro-6-methylnicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-6-methylnicotinic acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 2-Chloro-6-methylnicotinic acid manufacturers
- Product
- 2-Chloro-6-methylnicotinic acid 30529-70-5
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-07-14
- Product
- 2-Chloro-6-methylnicotinic acid 30529-70-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2-Chloro-6-methylnicotinic acid 30529-70-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06