ChemicalBook > CAS DataBase List > SAR245409

SAR245409

Product Name
SAR245409
CAS No.
934493-76-2
Chemical Name
SAR245409
Synonyms
CS-1242;Voxtalisib;XL-765;XL 765;Voxtalisib (XL-765);Voxtalisib (SAR245409);Voxtalisib (XL765, SAR245409);SAR245409 (XL765, Voxtalisib);Voxtalisib (SAR245409, XL765) Analogue;2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one;2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
CBNumber
CB62715669
Molecular Formula
C13H14N6O
Formula Weight
270.29
MOL File
934493-76-2.mol
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SAR245409 Property

Boiling point:
605.0±65.0 °C(Predicted)
Density 
1.397±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 10 mg/mL (37.00 mM; Need ultrasonic)
form 
Powder
pka
12.54±0.10(Predicted)
color 
Off-white to brown
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Safety

HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30323
Product name
Voxtalisib
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
30323
Product name
Voxtalisib
Packaging
50mg
Price
$578
Updated
2024/03/01
Cayman Chemical
Product number
30323
Product name
Voxtalisib
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
30323
Product name
Voxtalisib
Packaging
25mg
Price
$347
Updated
2024/03/01
ChemScene
Product number
CS-3163
Product name
Voxtalisib
Purity
99.46%
Packaging
5mg
Price
$84
Updated
2021/12/16
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SAR245409 Chemical Properties,Usage,Production

Definition

ChEBI: 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone is a pyrazolopyridine.

Biological Activity

Voxtalisib (SAR245409, XL765) is a dual mTOR/PI3K inhibitor with the strongest effect on p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.

in vitro

Voxtalisib (XL765) is the first oral dual inhibitor of PI3K and mTOR with IC50 of 39, 113, 9, 43, and ~150 nM for p110α, β, γ, δ, and mTOR, respectively. In vitro, XL765 decreased cell viability in a concentration-dependent manner.

in vivo

Oral feeding of XL765 resulted in a 12-fold increase in the number of mid-stage tumor declines compared to the control group. XL765 showed activity either alone or in combination with other drugs in various GBM xenografts. XL765 induces downregulation of PI3K downstream phosphorylated proteins: pAkt and pPRAS40, and mTOR downstream phosphorylated proteins: pS6 and p4EBP1 in cultured human xenograft tumors in vitro.

target

PI3Kγ

SAR245409 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR245409 Suppliers

NCE Biomedical Co.,Ltd.
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934493-76-2, SAR245409Related Search:


  • Voxtalisib (XL-765)
  • Voxtalisib (XL765, SAR245409)
  • Voxtalisib
  • 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
  • Voxtalisib (SAR245409)
  • SAR245409 (XL765, Voxtalisib)
  • Voxtalisib (SAR245409, XL765) Analogue
  • CS-1242
  • XL-765;XL 765
  • Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-
  • 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
  • SAR-245409,SAR 245409,inhibit,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,XL 765,mTOR,PI3K,Inhibitor,Voxtalisib,XL-765
  • 934493-76-2