SAR245409
- Product Name
- SAR245409
- CAS No.
- 934493-76-2
- Chemical Name
- SAR245409
- Synonyms
- CS-1242;Voxtalisib;XL-765;XL 765;Voxtalisib (XL-765);Voxtalisib (SAR245409);Voxtalisib (XL765, SAR245409);SAR245409 (XL765, Voxtalisib);Voxtalisib (SAR245409, XL765) Analogue;2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one;2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
- CBNumber
- CB62715669
- Molecular Formula
- C13H14N6O
- Formula Weight
- 270.29
- MOL File
- 934493-76-2.mol
SAR245409 Property
- Boiling point:
- 605.0±65.0 °C(Predicted)
- Density
- 1.397±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 10 mg/mL (37.00 mM; Need ultrasonic)
- form
- Powder
- pka
- 12.54±0.10(Predicted)
- color
- Off-white to brown
Safety
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304IF INHALED:
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362Take off contaminated clothing and wash before reuse.
P403Store in a well-ventilated place.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 30323
- Product name
- Voxtalisib
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 30323
- Product name
- Voxtalisib
- Packaging
- 50mg
- Price
- $578
- Updated
- 2024/03/01
- Product number
- 30323
- Product name
- Voxtalisib
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 30323
- Product name
- Voxtalisib
- Packaging
- 25mg
- Price
- $347
- Updated
- 2024/03/01
- Product number
- CS-3163
- Product name
- Voxtalisib
- Purity
- 99.46%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2021/12/16
SAR245409 Chemical Properties,Usage,Production
Definition
ChEBI: 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone is a pyrazolopyridine.
Biological Activity
Voxtalisib (SAR245409, XL765) is a dual mTOR/PI3K inhibitor with the strongest effect on p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
in vitro
Voxtalisib (XL765) is the first oral dual inhibitor of PI3K and mTOR with IC50 of 39, 113, 9, 43, and ~150 nM for p110α, β, γ, δ, and mTOR, respectively. In vitro, XL765 decreased cell viability in a concentration-dependent manner.
in vivo
Oral feeding of XL765 resulted in a 12-fold increase in the number of mid-stage tumor declines compared to the control group. XL765 showed activity either alone or in combination with other drugs in various GBM xenografts. XL765 induces downregulation of PI3K downstream phosphorylated proteins: pAkt and pPRAS40, and mTOR downstream phosphorylated proteins: pS6 and p4EBP1 in cultured human xenograft tumors in vitro.
target
PI3Kγ
SAR245409 Preparation Products And Raw materials
Raw materials
Preparation Products
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