ChemicalBook > CAS DataBase List > 1-Methyl-1H-pyrazole-3-carboxylic acid
1-Methyl-1H-pyrazole-3-carboxylic acid
- Product Name
- 1-Methyl-1H-pyrazole-3-carboxylic acid
- CAS No.
- 25016-20-0
- Chemical Name
- 1-Methyl-1H-pyrazole-3-carboxylic acid
- Synonyms
- SKL262;AKOS B000139;AKOS PAO-0549;TIMTEC-BB SBB000008;ART-CHEM-BB B000139;3-Carboxy-1-methyl-1H-pyrazole;1-METHYLPYRAZOLE-3-CARBOXYLIC ACID;1-Methyl-1H-pyrazol-3-carboxylic acid;1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID;1-Methylpyrazole-3-carboxylic Acid >
- CBNumber
- CB6273183
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 25016-20-0.mol
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1-Methyl-1H-pyrazole-3-carboxylic acid Property
- Melting point:
- 150-152 ºC
- Boiling point:
- 306.9±15.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.05±0.10(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C5H6N2O2/c1-7-3-2-4(6-7)5(8)9/h2-3H,1H3,(H,8,9)
- InChIKey
- YBFIKNNFQIBIQZ-UHFFFAOYSA-N
- SMILES
- N1(C)C=CC(C(O)=O)=N1
- CAS DataBase Reference
- 25016-20-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 22-26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933199090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- M2642
- Product name
- 1-Methylpyrazole-3-carboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 200mg
- Price
- $24
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2642
- Product name
- 1-Methylpyrazole-3-carboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $76
- Updated
- 2025/07/31
TRC
- Product number
- M320930
- Product name
- 1-Methyl-1H-pyrazole-3-carboxylicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- J20303
- Product name
- 1-Methylpyrazole-3-carboxylic Acid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
AK Scientific
- Product number
- J92175
- Product name
- 1-Methylpyrazole-3-carboxylic Acid
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
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1-Methyl-1H-pyrazole-3-carboxylic acid Chemical Properties,Usage,Production
Uses
1-Methyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Definition
ChEBI: 1-methyl-pyrazole-3-carboxylic acid is a member of the class of pyrazoles that is N-methylpyrazole substituted by a carboxy group at position 3. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It is functionally related to a N-methylpyrazole.
Synthesis
1621-91-6
77-78-1
16034-46-1
25016-20-0
Over 45 minutes, dimethyl sulfate (236 g, 177 mL, 1.87 mol) was slowly added dropwise to a stirred solution of pyrazole-3-carboxylic acid (200 g, 1.78 mol) dissolved in 20% aqueous sodium hydroxide (850 mL) at 40 °C. The reaction mixture was heated at 80 °C for 2 h and subsequently cooled to room temperature. The reaction mixture was filtered and the filtrate was acidified to pH 1 with concentrated hydrochloric acid, the precipitate was collected by filtration, washed with water and dried under vacuum to afford 1-methyl-1H-pyrazole-5-carboxylic acid (85 g, 38% yield). The remaining filtrate was concentrated to 800 mL in vacuum and extracted with chloroform (15 x 400 mL) several times. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated in vacuum to remove the solvent. The residue was recrystallized by isopropanol to give 1-methyl-1H-pyrazole-3-carboxylic acid (74 g) as a white crystalline solid.
References
[1] J. Gen. Chem. USSR (Engl. Transl.), 1982, vol. 52, # 11, p. 2291 - 2296
[2] Zhurnal Obshchei Khimii, 1982, vol. 52, # 11, p. 2592 - 2598
[3] J. Gen. Chem. USSR (Engl. Transl.), 1982, vol. 52, # 11, p. 2291 - 2296
[4] Zhurnal Obshchei Khimii, 1982, vol. 52, # 11, p. 2592 - 2598
[5] Patent: WO2004/58702, 2004, A2. Location in patent: Page 30-31; 24
1-Methyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Methyl-1H-pyrazole-3-carboxylic acid manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 1-Methyl-1H-pyrazole-3-carboxylic acid 25016-20-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
Career Henan Chemical Co
- Product
- 1-Methyl-1H-pyrazole-3-carboxylic acid 25016-20-0
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-23
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