ChemicalBook > CAS DataBase List > 3-Hydroxy-4-methoxybenzonitrile

3-Hydroxy-4-methoxybenzonitrile

Product Name
3-Hydroxy-4-methoxybenzonitrile
CAS No.
52805-46-6
Chemical Name
3-Hydroxy-4-methoxybenzonitrile
Synonyms
Benzonitrile, 3-hydroxy-4-Methoxy-;ISOVANILLONITRILE;CBI-BB ZERO/005397;2-methoxy-5-cyanophenol;5-Cyano-2-methoxyphenol;3-Hydroxy-4-methoxybenzonitril;3-HYDROXY-4-METHOXYBENZONITRILE;3-Hydroxy-4-methoxy benzonitrile 95+%;3-Hydroxy-4-methoxybenzonitrile ISO 9001：2015 REACH;3-HYDROXY-4-METHOXYBENZONITRILE (ISOVANILLONITRILE)
CBNumber
CB6287199
Molecular Formula
C8H7NO2
Formula Weight
149.15
MOL File
52805-46-6.mol
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3-Hydroxy-4-methoxybenzonitrile Property

Melting point:
124 °C
Boiling point:
300.8±27.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
8.59±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
52805-46-6(CAS DataBase Reference)
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Safety

HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
H972653
Product name
3-Hydroxy-4-methoxybenzonitrile
Packaging
100mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J53639
Product name
3-Hydroxy-4-methoxybenzonitrile
Packaging
1g
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
074666
Product name
3-Hydroxy-4-methoxybenzonitrile
Purity
95+%
Packaging
5g
Price
$32
Updated
2021/12/16
ChemScene
Product number
CS-W002933
Product name
3-Hydroxy-4-methoxybenzonitrile
Purity
99.87%
Packaging
25g
Price
$36
Updated
2021/12/16
Apolloscientific
Product number
OR345595
Product name
3-Hydroxy-4-methoxybenzonitrile
Purity
95+%
Packaging
25g
Price
$70
Updated
2021/12/16
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3-Hydroxy-4-methoxybenzonitrile Chemical Properties,Usage,Production

Synthesis

621-59-0

52805-46-6

The general procedure for synthesizing 3-hydroxy-4-methoxybenzonitrile from isovanillin was as follows: 14.2 g of isovanillin was dissolved in 75 mL of formic acid, 15 g of sodium formate was added, and stirred at 85 °C. Subsequently, 9 g of hydroxylamine hydrochloride was added in batches, and the reaction mixture was kept at 85 °C and continued to be stirred for 4 hours. Upon completion of the reaction, the mixture was poured into a nearly saturated sodium chloride solution and a precipitate was precipitated. The precipitate was separated by filtration, washed sequentially with water and petroleum ether, and dried to give the product. The yield was 14.2 g. The yield was 93% of the theoretical value. The product was analyzed by HPLC-MS (Method D) with a retention time (Rt) of 1.18 min.

References

[1] Patent: WO2011/92128, 2011, A1. Location in patent: Page/Page column 37
[2] Patent: US2012/28939, 2012, A1. Location in patent: Page/Page column 18
[3] Patent: CN105330586, 2016, A. Location in patent: Paragraph 0055; 0056
[4] Patent: CN105461602, 2016, A. Location in patent: Paragraph 0049; 0050
[5] Molecules, 2017, vol. 22, # 10,

3-Hydroxy-4-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Hydroxy-4-methoxybenzonitrile manufacturers

Career Henan Chemical Co
Product
3-Hydroxy-4-methoxybenzonitrile 52805-46-6
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-12
Career Henan Chemical Co
Product
3-Hydroxy-4-methoxybenzonitrile 52805-46-6
Price
US $8.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-15

52805-46-6, 3-Hydroxy-4-methoxybenzonitrileRelated Search:

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  • ISOVANILLONITRILE
  • CBI-BB ZERO/005397
  • Benzonitrile, 3-hydroxy-4-Methoxy-
  • 3-HYDROXY-4-METHOXYBENZONITRILE
  • 3-HYDROXY-4-METHOXYBENZONITRILE (ISOVANILLONITRILE)
  • 3-Hydroxy-4-methoxybenzonitril
  • 5-Cyano-2-methoxyphenol
  • Gefitinib IMpurity (3-Hydroxy-4-Methoxybenzonitrile)
  • 3-Hydroxy-4-methoxy benzonitrile 95+%
  • 3-Hydroxy-4-methoxybenzonitrile ISO 9001：2015 REACH
  • 2-methoxy-5-cyanophenol
  • 52805-46-6
  • Gefitinib
  • Aromatic Nitriles
  • bc0001