ChemicalBook > CAS DataBase List > Phthalic acid

Phthalic acid

Product Name
Phthalic acid
CAS No.
88-99-3
Chemical Name
Phthalic acid
Synonyms
1,2-BENZENEDICARBOXYLIC ACID;O-PHTHALIC ACID;BENZENE-1,2-DICARBOXYLIC ACID;Phthalic acid,99%;Fluorescein EP Impurity B;NSC 5348;Phthalsure;Sunftal 20;THALIC ACID;phthalicaci
CBNumber
CB6289456
Molecular Formula
C8H6O4
Formula Weight
166.13
MOL File
88-99-3.mol
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Phthalic acid Property

Melting point:
210-211 °C (dec.) (lit.)
Boiling point:
214.32°C (rough estimate)
Density 
1.59 g/cm3 at 15 °C
vapor pressure 
7.8 hPa (191 °C)
refractive index 
1.5100 (estimate)
Flash point:
168 °C
storage temp. 
Store below +30°C.
solubility 
methanol: 0.1 g/mL, clear
pka
2.89(at 25℃)
form 
Powder
color 
White
PH
3.2(1 mM solution);2.55(10 mM solution);2(100 mM solution);
Water Solubility 
7 g/L (25 ºC)
Merck 
14,7371
BRN 
608199
Dielectric constant
5.1（Ambient）
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
XNGIFLGASWRNHJ-UHFFFAOYSA-N
LogP
0.73 at 20℃
CAS DataBase Reference
88-99-3(CAS DataBase Reference)
NIST Chemistry Reference
1,2-Benzenedicarboxylic acid(88-99-3)
EPA Substance Registry System
Phthalic acid (88-99-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
1
RTECS 
TH9625000
TSCA 
Yes
HS Code 
29173980
Hazardous Substances Data
88-99-3(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 7.9 g/kg (Shaffer)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22298
Product name
Phthalic acid
Purity
for synthesis
Packaging
100g
Price
$44.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22298
Product name
Phthalic acid
Purity
for synthesis
Packaging
1kg
Price
$175
Updated
2024/03/01
Sigma-Aldrich
Product number
402915
Product name
Phthalic acid
Purity
ACS reagent, ≥99.5%
Packaging
1kg
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
1535899
Product name
Phthalic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$443
Updated
2024/03/01
TCI Chemical
Product number
P0287
Product name
Phthalic Acid
Purity
>99.0%(GC)(T)
Packaging
25g
Price
$21
Updated
2024/03/01
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Phthalic acid Chemical Properties,Usage,Production

Description

Phthalic acid is an aromatic dicarboxylic acid, with formula C6H4(CO2H)2. It is an isomer of isophthalic acid and terephthalic acid. Although phthalic acid is of modest commercial importance, the closely related derivative phthalic anhydride is a commodity chemical produced on a large scale.

Chemical Properties

PHTHALIC ACID,C6H4(COOH)2, mp 208 °C (ortho), 330 °C (meta and iso), the ortho form sublimes and the meta and iso forms decompose with heat, sp gr 1.593 (ortho). Phthalic acid is very slightly soluble in H2O, soluble in alcohol, and slightly soluble in ether. The solid form is colorless, crystalline

Uses

It is a dibasic acid, with pKa's of 2.89 and 5.51. The mono potassium salt, potassium hydrogen phthalate is a standard acid in analytical chemistry. Typically phthalate esters are prepared from the widely available phthalic anhydride. Reduction of phthalic acid with sodium amalgam in the presence of water gives the 1,3- cyclohexadiene derivative.

Uses

Phthalic Acid (Phenyl-13C6, D4) is labelled Phthalic Acid (P384480) which is an organic reagent used to synthesize phthalates.

Production Methods

Phthalic acid is produced by the catalytic oxidation of naphthalene directly to phthalic anhydride and a subsequent hydrolysis of the anhydride.
Phthalic acid was first obtained by French chemist Auguste Laurent in 1836 by oxidizing naphthalene tetrachloride. Believing the resulting substance to be a naphthalene derivative, he named it "naphthalic acid". After the Swiss chemist Jean Charles Galissard de Marignac determined its correct formula, Laurent gave it its present name. Manufacturing methods in the nineteenth century included oxidation of naphthalene tetrachloride with nitric acid, or, better, oxidation of the hydrocarbon with fuming sulfuric acid, using mercury or mercury(II) sulfate as a catalyst.

Definition

phthalic acid: colourlesscrystalline dicarboxylic acid,C6H4(COOH)2; r.d. 1.6; m.p. 207°C.The two –COOH groups are substitutedon adjacent carbon atoms ofthe ring, the technical name beingbenzene-1,2-dicarboxylic acid. Theacid is made from phthalic anhydride(benzene-1,2-dicarboxylic anhydride,C8H4O3), which is made by the catalyticoxidation of naphthalene. Theanhydride is used in making plasticizersand polyester resins.

Definition

ChEBI: A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2414, 1965 DOI: 10.1021/jo01018a074

General Description

White crystals or fine white powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phthalic acid is a carboxylic acid. Phthalic acid is sensitive to exposure to extreme heat. Phthalic acid reacts violently with nitric acid. Phthalic acid is incompatible with sodium nitrite. Phthalic acid is also incompatible with oxidizers. .

Fire Hazard

Phthalic acid is combustible.

Flammability and Explosibility

Not classified

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. A skin and mucous membrane irritant. Combustible when heated. In the form of dust (anhydride) it can explode. Mixtures with sodmm nitrite explode when heated. Violent reaction with HNO3. When heated to decomposition it emits acrid smoke and irritating fumes. Used in synthesis of dyes and dyestuffs, in medcines and perfumes.

Safety

The toxicity of phthalic acid is low with LD50 (mouse) of 550 mg/kg. However, many phthalate esters have been implicated as endocrine disruptors.

Purification Methods

Crystallise phthalic acid from water. [Beilstein 9 IV 3167.]

Isomers

Phthalic acid is one of three isomers of benzene dicarboxylic acid, the others being iso phthalic acid and terephthalic acid. Sometimes the term "phthalic acids" is used to refer to this family of isomers, but in the singular, "phthalic acid", refers exclusively to the ortho- isomer.

Phthalic acid Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Phthalic anhydride Nitric acid

Preparation Products

Phthalonitrile complex polystyrene high efficiency anticorrosion paint Oxendolone MERBROMIN (4S)-HYDROXY-3-METHYL-2-(2-PROPENYL)-2-CYCLOPENTENE-1-ONE Phosmet DI-N-OCTYL PHTHALATE Benzoic acid Bis(2-ethylhexyl) phthalate cis-1,2-Diaminocyclohexane Tetramethrin Dimethyl phthalate 4-Aminopyridine
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View Lastest Price from Phthalic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Phthalic Acid 88-99-3
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10ton
Release date
2024-05-21
Hebei Weibang Biotechnology Co., Ltd
Product
Phthalic acid 88-99-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
phthalic acid 88-99-3
Price
US $50000.00/T
Min. Order
1T
Purity
99%
Supply Ability
20tons
Release date
2020-07-09

88-99-3, Phthalic acidRelated Search:

Diallyl ester of phthalic acid,Diallyl ester o-phthalic acid,Diallylester phthalic acid Glycine Allylbenzene Terephthalic acid Ethyl 2-(Chlorosulfonyl)acetate Ethylbenzene Folic acid Citric acid Benzene (S)-2-Chloromandelic acid Benzyl butyl phthalate OXALIC ACID Dacthal Isophthalic acid Phthalic acid dinitrile Maleic acid Acrylic acid Fluorescein

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