Tos-PEG4-t-butyl ester
- Product Name
- Tos-PEG4-t-butyl ester
- CAS No.
- 217817-01-1
- Chemical Name
- Tos-PEG4-t-butyl ester
- Synonyms
- Tos-PEG4-Boc;Tos-PEG3-COOtBu;Tos-PEG3-CH2CH2COOtBu;Tos-PEG4-t-butyl ester;Tos-PEG4-t-butyl ester (Tos-PEG4-Boc);tert-butyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate;tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate;tert-butyl 3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoate;3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester;Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
- CBNumber
- CB63062690
- Molecular Formula
- C20H32O8S
- Formula Weight
- 432.53
- MOL File
- 217817-01-1.mol
Tos-PEG4-t-butyl ester Property
- Boiling point:
- 528.5±45.0 °C(Predicted)
- Density
- 1.154±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- BP-20636
- Product name
- Tos-PEG4-t-butylester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- AS104012
- Product name
- Tos-PEG3-CH2CH2COOtBu
- Purity
- 95+%
- Packaging
- 1g
- Price
- $421
- Updated
- 2021/12/16
- Product number
- BIPG1863
- Product name
- Tos-PEG4-t-butyl ester
- Packaging
- 250mg
- Price
- $428
- Updated
- 2021/12/16
- Product number
- BP-20636
- Product name
- Tos-PEG4-t-butylester
- Purity
- 98%
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 179768
- Product name
- 3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester
- Purity
- 95%
- Packaging
- 1g
- Price
- $660
- Updated
- 2021/12/16
Tos-PEG4-t-butyl ester Chemical Properties,Usage,Production
Description
Tos-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
IC 50
PEGs; Alkyl/ether
References
[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826
Tos-PEG4-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Tos-PEG4-t-butyl ester Suppliers
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- +1-781-999-5354; +17819995354
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- United States
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- support@targetmol.com
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- United States
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- tp@aladdinsci.com
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- United States
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- --
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- United States
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View Lastest Price from Tos-PEG4-t-butyl ester manufacturers
- Product
- Tos-PEG4-COOtBu 217817-01-1
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-27