ChemicalBook > CAS DataBase List > 5-Pyrazolecarboxylic acid

5-Pyrazolecarboxylic acid

Product Name
5-Pyrazolecarboxylic acid
CAS No.
1621-91-6
Chemical Name
5-Pyrazolecarboxylic acid
Synonyms
1H-PYRAZOLE-3-CARBOXYLIC ACID;PYRAZOLE-3-CARBOXYLIC ACID;Pyrazole-5-carboxylic acid;SKL261;AKOS B000140;AKOS BB-9039;01H-Pyrazole;3- pyrazol formate;ART-CHEM-BB B000140;TIMTEC-BB SBB000005
CBNumber
CB6317652
Molecular Formula
C4H4N2O2
Formula Weight
112.09
MOL File
1621-91-6.mol
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5-Pyrazolecarboxylic acid Property

Melting point:
211°C
Boiling point:
417.1±18.0 °C(Predicted)
Density 
1.524±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
3.98±0.10(Predicted)
form 
Powder
color 
White
λmax
260nm(MeOH)(lit.)
InChI
InChI=1S/C4H4N2O2/c7-4(8)3-1-2-5-6-3/h1-2H,(H,5,6)(H,7,8)
InChIKey
KOPFEFZSAMLEHK-UHFFFAOYSA-N
SMILES
N1C=CC(C(O)=O)=N1
CAS DataBase Reference
1621-91-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
38
Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
707384
Product name
1H-Pyrazole-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$27.44
Updated
2025/07/31
TCI Chemical
Product number
P1862
Product name
Pyrazole-3-carboxylic Acid
Purity
>98.0%(HPLC)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
P1862
Product name
Pyrazole-3-carboxylic Acid
Purity
>98.0%(HPLC)
Packaging
5g
Price
$104
Updated
2025/07/31
TRC
Product number
B529765
Product name
1H-Pyrazole-3-carboxylic acid
Packaging
250mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
008021
Product name
1H-Pyrazole-3-carboxylic acid
Packaging
1g
Price
$10
Updated
2021/12/16
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5-Pyrazolecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown powder

Uses

1H-pyrazole-3-carboxylic Acid is a histone lysine demethylase KDM4C and proline racemase inhibitor.

Synthesis

1453-58-3

1621-91-6

The general procedure for the synthesis of pyrazole-3-carboxylic acid from 3-methylpyrazole was as follows: an aqueous solution of potassium permanganate (KMnO4, 40.9 g, 0.26 mol) was slowly added to a stirring solution of 3-methyl-1H-pyrazole (9.8 mL, 0.12 mol) dissolved in 0.5 L of water. The reaction mixture was heated to reflux and maintained for 5 hours. After completion of the reaction, the black suspension was cooled and filtered. The filtrate was concentrated to a smaller volume and acidified with 3 N hydrochloric acid (HCl). Subsequently, the precipitated white solid product was collected and washed with ethyl ether (Et2O) to give the final pyrazole-3-carboxylic acid in 100% yield.

References

[1] Journal of the American Chemical Society, 2000, vol. 122, # 44, p. 10810 - 10820
[2] Patent: WO2004/80999, 2004, A1. Location in patent: Page 43
[3] Russian Journal of Physical Chemistry, 1992, vol. 66, # 4, p. 463 - 465
[4] Zhurnal Fizicheskoi Khimii, 1992, vol. 66, # 4, p. 871 - 874
[5] Organic Mass Spectrometry, 1982, vol. 17, # 7, p. 299 - 303

5-Pyrazolecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Pyrazolecarboxylic acid Suppliers

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View Lastest Price from 5-Pyrazolecarboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Pyrazolecarboxylic acid 1621-91-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-29
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Pyrazolecarboxylic acid 1621-91-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Hebei Chuanghai Biotechnology Co,.LTD
Product
5-Pyrazolecarboxylic Acid 1621-91-6
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23

1621-91-6, 5-Pyrazolecarboxylic acidRelated Search:

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