SMI-16a
- Product Name
- SMI-16a
- CAS No.
- 587852-28-6
- Chemical Name
- SMI-16a
- Synonyms
- SMI-16a;SMI-16a, 10 mM in DMSO;SMI-16A;SMI 16A;SMI16A;PIM1/2 Kinase Inhibitor VI;SMI-16a(PIM1/2 Kinase Inhibitor VI);5-(4-propoxybenzylidene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]-;SMI-16a,SMI 16a,inhibit,SMI16a,Pim,Inhibitor,Pim kinases
- CBNumber
- CB63313558
- Molecular Formula
- C13H13NO3S
- Formula Weight
- 263.31
- MOL File
- 587852-28-6.mol
SMI-16a Property
- Melting point:
- 186.3-188.4 °C
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Ethanol:3.0(Max Conc. mg/mL);11.39(Max Conc. mM)
- form
- A solid
- pka
- 7.27±0.20(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 526524
- Product name
- PIM1/2 Kinase Inhibitor VI
- Purity
- The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor
- Packaging
- 5 mg
- Price
- $126
- Updated
- 2025/07/31
- Product number
- 29456
- Product name
- SMI-16a
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29456
- Product name
- SMI-16a
- Packaging
- 25mg
- Price
- $365
- Updated
- 2024/03/01
- Product number
- 29456
- Product name
- SMI-16a
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- CS-6913
- Product name
- SMI-16a
- Purity
- 99.70%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2021/12/16
SMI-16a Chemical Properties,Usage,Production
Description
SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM). It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G1 phase in DU145 cells.
Uses
SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.
in vivo
Mice tolerate intraperitoneal dose of SMI-16a is 50 mg/kg daily for 5 days, while 100 mg/kg is overtly toxic. Treatment of the animals with SMI-16a for 5 days per week reduces the growth of tumors by approximately 50% and does not cause a loss of body weight. Subchronic dosing with SMI-16a does not affect the levels of red, white blood cells, including lymphocytes, monocytes, and granulocytes, indicating that the compound does not have myelosuppressive effects. SMI-16a does not have toxicity toward the liver as the albumin, alkaline phosphatase, and alanine aminotransferase levels are unchanged [1]. SMI-16a effectively prevents bone destruction while suppressing MM tumor growth in MM animal models[2].
IC 50
PIM1; PIM2
References
[1] Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86. DOI:10.1021/jm800937p
[2] Hiasa M, et al. Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma. Leukemia. 2015 Jan;29(1):207-17. DOI:10.1038/leu.2014.147
SMI-16a Preparation Products And Raw materials
Raw materials
Preparation Products
SMI-16a Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58
View Lastest Price from SMI-16a manufacturers
- Product
- SMI-16a 587852-28-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23