5-Fluorouridine

Product Name: 5-Fluorouridine
CAS No.: 316-46-1
Chemical Name: 5-Fluorouridine
Synonyms: FUR;5-FU;FURD;5-fur;5-FUrd;NSC 146604;NSC 519273;FLUOROURIDINE;5-FLUOROIDINE;5-fluoro-uridin
CBNumber: CB6346346
Molecular Formula: C9H11FN2O6
Formula Weight: 262.19
MOL File: 316-46-1.mol

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5-Fluorouridine Property

Melting point:: 182-184 °C
alpha: 17 º (c=2, water 25 ºC)
Density: 1.4200 (estimate)
refractive index: 18 ° (C=1, H2O)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
pka: 7.63±0.10(Predicted)
form: Powder
color: White
Water Solubility: soluble
BRN: 33662
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 316-46-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 40-68-36/37/38
Safety Statements: 22-26-36/37-36/37/39-27-24/25
WGK Germany: 3
RTECS: YU8050000
F: 10
Hazard Note: Harmful
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F5130
Product name: 5-Fluorouridine
Purity: proapoptotic anitproliferative plant growth regulator
Packaging: 100mg
Price: $124
Updated: 2024/03/01

Sigma-Aldrich

Product number: F5130
Product name: 5-Fluorouridine
Purity: proapoptotic anitproliferative plant growth regulator
Packaging: 1g
Price: $683
Updated: 2024/03/01

TCI Chemical

Product number: F0636
Product name: 5-Fluorouridine
Purity: >98.0%(T)
Packaging: 1g
Price: $50
Updated: 2024/03/01

TCI Chemical

Product number: F0636
Product name: 5-Fluorouridine
Purity: >98.0%(T)
Packaging: 5g
Price: $149
Updated: 2024/03/01

Alfa Aesar

Product number: J62083
Product name: 5-Fluorouridine, 97%
Packaging: 1g
Price: $56.65
Updated: 2024/03/01

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5-Fluorouridine Chemical Properties,Usage,Production

Description

5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.

Chemical Properties

White Powder

Uses

Antihypertensive

Uses

5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.

Uses

5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).

Definition

ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.

General Description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Purification Methods

5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]

References

1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297

5-Fluorouridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluorouridine Suppliers

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View Lastest Price from 5-Fluorouridine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Fluorouridine 316-46-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 5-Fluorouridine 316-46-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

316-46-1, 5-Fluorouridine Related Search:

5-Fluorouracil 5-Fluorouridine Floxuridine 2'-DEOXY-2'-FLUOROURIDINE,2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE) 5'-DEOXY-5-FLUOROURIDINE DMT-2′Fluoro-dU Phosphoramidite Uracil 5-Fluoropyrimidine 5'-Deoxy-2',3'-O-isopropylidene-5-fluorouridine 2',3'-DIDEOXY-3'-FLUOROURIDINE 5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine 2'-DEOXY-5-FLUOROURIDINE, [3H]- 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE 2',3'-dideoxy-5-fluorouridine 5-Fluorouridine 2'-Deoxy-5-fluorouridine 3',5'-dioctanoate 2'-Deoxy-5-fluorouridine 3',5'-dibutanoate 5'-O-(9-Octadecenoyl)-5-fluorouridine

1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-fluoropyrimidine-2,4-dione

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1

5-fluoro-uridin

5-fur

Uridine, 5-fluoro-

FURD

FLUOROURIDINE

1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE

5-FLUORO-1-(BETA-D-RIBOFURANOSYL)URACIL

5-FU

5-FLUOROURACIL-1BETA-D-RIBOFURANOSIDE

2,4-DIHYDROXY-5-FLUORO-1-BETA-D-RIBOFURANOSYLPYRIMIDINE

5-fluorouracil 1β-d-ribofuranoside

5-Fluorouridine97%

5-FLUOROURIDINE, 98+%

5-Fluorouridine

5-FLUOROIDINE

(2'R,3'R,4'S,5'R)-1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione

1-(beta-D-Ribofuranosyl)-5-fluorouracil

5-FLUOROURIDINE extrapure

5-Fluorouracil 1β-D-ribofuranoside, FUrd

1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione

5-FLUOROURIDINE, 99+%

FUR

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-fluoropyriMidine-2,4(1H,3H)-dione

5-FUrd

NSC 146604

NSC 519273

FUrd 1-(beta-D-Ribofuranosyl)-5-fluorouracil

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3

5-Fluorouridine&gt

5-Fluorouridine USP/EP/BP

5-Fluorouridine (5-FUrd) extrapure, 98%

5-Fluorouridine, impurity of 5-fluorouracil

5- fluorouracil nucleoside

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione

316-46-1

C9H11FN2O6

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