Boc-Tyr(Me)-OH

Product Name: Boc-Tyr(Me)-OH
CAS No.: 53267-93-9
Chemical Name: Boc-Tyr(Me)-OH
Synonyms: Boc-Tyr(Me);BOC-L-TYR(ME);BOC-TYR(ME)-OH;Boc-O-Me-L-Tyr;BOC-L-TYR(ME)-OH;BOC-S-TYR(ME)-OH;BOC-PHE(4-OME)-OH;Boc-4-Methoxy-Phe;BOC-L-4-METHOXYPHE;BOC-TYROSINE(ME)-OH
CBNumber: CB6361822
Molecular Formula: C15H21NO5
Formula Weight: 295.33
MOL File: 53267-93-9.mol

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Boc-Tyr(Me)-OH Property

Boiling point:: 462.0±40.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.00±0.10(Predicted)
form: Solid
color: White to off-white
optical activity: Consistent with structure
InChI: InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)9-10-5-7-11(20-4)8-6-10/h5-8,12H,9H2,1-4H3,(H,16,19)(H,17,18)/t12-/m0/s1
InChIKey: SLWWWZWJISHVOU-LBPRGKRZSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 53267-93-9(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53071
Product name: Boc-Tyr(Me)-OH
Purity: Novabiochem?
Packaging: 5G
Price: $316
Updated: 2025/07/31

TCI Chemical

Product number: D6223
Product name: Boc-Tyr(Me)-OH
Packaging: 5G
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: D6223
Product name: Boc-Tyr(Me)-OH
Packaging: 25G
Price: $339
Updated: 2025/07/31

TRC

Product number: B391930
Product name: Boc-Tyr(Me)-OH
Packaging: 500mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B391930
Product name: Boc-Tyr(Me)-OH
Packaging: 1g
Price: $65
Updated: 2021/12/16

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Boc-Tyr(Me)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-Tyr(Me)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Application

Boc-Tyr(Me)-OH, also known as N-Boc-O-methyl-L-tyrosine, is used to incorporate O-methyltyrosine, a structural component of many potent vasopressin antagonists and oxytocin antagonists.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

94790-24-6

53267-93-9

To a solution of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propionate (498 mg, 1.61 mmol) in THF/MeOH/H2O (3:1:1, 5 mL) was added LiOH-H2O (142 mg, 3.22 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 1 h and then evaporated to remove the organic solvent. The residue was treated with 15% aqueous citric acid solution, adjusting the pH to 3, and subsequently extracted with ethyl acetate (35 mL). The combined organic layers were washed with brine (5 mL), dried over anhydrous Na2SO4 and concentrated in vacuum. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether=2:1) to afford (S)-2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid (466 mg, 98%) as a colorless oil.1H NMR (300 MHz, CD3OD): δ 7.13 (2H, d, J=8.4 Hz), 6.82 (2H d, J=8.4 Hz), 4.31-4.29 (1H, m), 3.73 (3H, s), 3.08 (1H, dd, J=13.8, 4.5 Hz), 2.85 (1H, dd, J=13.5, 8.7 Hz), 1.38 (9H, s).13C NMR (75 MHz, CD3OD): δ 175.42, 159.95, 157.00, 159.95, 157.00 (9H, s). 159.95, 157.67, 131.27, 130.37, 114.81, 80.50, 56.37, 55.64, 37.86, 28.67.

References

[1] Tetrahedron, 2014, vol. 70, # 37, p. 6630 - 6640
[2] Patent: CN107353239, 2017, A. Location in patent: Paragraph 0173; 0174
[3] Patent: CN107468690, 2017, A. Location in patent: Paragraph 0173; 0174
[4] Synthesis, 1984, vol. NO. 7, p. 572 - 574
[5] Journal of Organic Chemistry, 1981, vol. 46, # 9, p. 1944 - 1946

Boc-Tyr(Me)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-Tyr(Me)-OH manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Boc-O-methyl-L-tyrosine 53267-93-9
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Tyr(me)-OH 53267-93-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-26

Henan Aochuang Chemical Co.,Ltd.

Product: Boc-O-methyl-L-tyrosine 53267-93-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

53267-93-9, Boc-Tyr(Me)-OHRelated Search:

N-(tert-Butoxycarbonyl)-L-phenylalanine 6-Aminocaproic acid 4-Nitro-3-phenyl-L-alanine H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH Glycine N-Carbobenzyloxyglycine Boc-D-Tyr-OH tert-Butanol Methylparaben Methyl acrylate Bensulfuron methyl Kresoxim-methyl BOC-L-Tyrosine Phenprobamate L-Tyrosine Boc-Aib-OH L-Phenylalanine Boc-2-Methyl-D-beta-phenylalanine

BOC-O-METHYL-L-TYROSINE

BOC-PHE(4-OME)-OH

BOC-P-METHOXY-PHE-OH

BOC-L-TYR(ME)

BOC-L-TYR(ME)-OH

BOC-L-4-METHOXYPHE

BOC-4-METHOXYPHENYLALANINE

BOC-4-METHOXY-PHE-OH

(S)-N-alpha-Tert-butyloxycarbonyl-O-methyltyrosine

N-ALPHA-T-BUTYLOXYCARBONYL-O-METHYL-L-TYROSINE

NALPHA-tert-Butoxycarbonyl-O-methyl-L-tyrosine

(S)-BOC-4-METHOXYPHENYLALANINE

N-(tert-butoxycarbonyl)-4-methoxyphenylalanine

N-(tert-butoxycarbonyl)-O-methyl-L-tyrosine

(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid

boc-4-Methoxy-phe-ohboc-tyr(me)-oh

Boc-Tyr(Me)

N-Boc-O-Methyl-L-tyrosine, 98%

3-(4-methoxyphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid

N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-Tyrosine

(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID

(S)-N-ALPHA-T-BUTYLOXYCARBONYL-O-METHYL-TYROSINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-O-METHYL-L-TYROSINE

N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-TYROSINE

N-ALPHA-T-BUTOXYCARBONYL-O-METHY-L-TYROSINE

N-ALPHA-T-BOC-P-METHOXY-L-PHENYLALANINE

N-ALPHA-T-BOC-O-METHYL-L-TYROSINE

N-ALPHA-T-BUTOXYCARBONYL-4-METHOXY-L-PHENYLALANINE

Boc-O-methyl-L-tyrosine≥ 99% (HPLC)

Boc-p-methoxy-L-Phe-OH

BOC-S-TYR(ME)-OH

BOC-TYR(ME)-OH

BOC-TYROSINE(ME)-OH

Boc-4-Methoxy-Phe

(Tert-Butoxy)Carbonyl Tyr(Me)-OH

L-4'-METHOXY-N-BOC-TYROSINE

Boc-O-Me-L-Tyr

L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-

Boc-O-methyl-L-tyrosine USP/EP/BP

Boc-L-4-Methoxyphenylalanine DCHA salt

Boc-O-methyl-L-tyrosine - 5 g

N-Boc-O-methyl-L-tyrosine

53267-93-9

Peptide Synthesis

Specialty Synthesis

Tyrosine

Amino Acid Derivatives

Boc-Amino acid series

Phenylalanine [Phe, F]

Unusual Amino Acids

Boc-Amino Acids and Derivative