2-Amino-3-fluorobenzoic acid
Application- Product Name
- 2-Amino-3-fluorobenzoic acid
- CAS No.
- 825-22-9
- Chemical Name
- 2-Amino-3-fluorobenzoic acid
- Synonyms
- Diaphonic acid;BUTTPARK 22\01-93;uorobenzenecarboxyL;2-AMino-3-fluorobenz;2-AMINO-3-FLUOROBENZOIC;3-FLUOROANTHRANILIC ACID;3-FluoroanthranilicAcid>2-Amino-3-fluorobenzoicAci;2-AMINO-3-FLUOROBENZOIC ACID;2-Amino-3-Fluoride Benzoic Acids
- CBNumber
- CB6368755
- Molecular Formula
- C7H6FNO2
- Formula Weight
- 155.13
- MOL File
- 825-22-9.mol
2-Amino-3-fluorobenzoic acid Property
- Melting point:
- 171-172°C
- Boiling point:
- 294.4±25.0 °C(Predicted)
- Density
- 1.430±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 4.60±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C7H6FNO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,9H2,(H,10,11)
- InChIKey
- KUHAYJJXXGBYBW-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=CC(F)=C1N
- CAS DataBase Reference
- 825-22-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-24/25
- HazardClass
- IRRITANT
- HS Code
- 29223990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F0570
- Product name
- 3-Fluoroanthranilic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- F0570
- Product name
- 3-Fluoroanthranilic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- A634628
- Product name
- 2-Amino-3-fluorobenzoicAcid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 008762
- Product name
- 2-Amino-3-fluorobenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $13
- Updated
- 2021/12/16
- Product number
- PC1089
- Product name
- 2-Amino-3-fluorobenzoicacid
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
2-Amino-3-fluorobenzoic acid Chemical Properties,Usage,Production
Application
2-Amino-3-fluorobenzoic acid is a carboxylic acid derivative and can be used as a pharmaceutical intermediate.
Chemical Properties
white to light yellow crystal powder
Synthesis
317-20-4
825-22-9
7-Fluoro-1H-indole-2,3-dione (13.0 g, 78.7 mmol) was used as raw material, which was dissolved in 10N sodium hydroxide solution (125 mL), heated to 70°C and stirred for 1 hour. At the same temperature, 30% hydrogen peroxide solution (25 mL) was added slowly and dropwise over 20 minutes and the reaction continued to be stirred at 70 °C for 1 hour. Upon completion of the reaction, the reaction solution was cooled in an ice bath and concentrated. Subsequently, hydrochloric acid was slowly added to adjust the pH of the solution to 4. The organic phase was extracted with ethyl acetate, and the extract was washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. The crystals were collected by filtration to finally obtain 2-amino-3-fluorobenzoic acid (7.15 g, 59% yield). The NMR hydrogen spectrum (CDCl3) data were as follows: δ 6.00 (2H, broad single peak), 6.60 (1H, double-triple peak, J = 5.2 Hz, 8.0 Hz), 7.16 (1H, multiple peaks, J = 1.4 Hz, 8.0 Hz, 11.2 Hz), 7.72 (1H, triple-double peaks, J = 1.4 Hz, 8.0 Hz), and one additional hydrogen signal was masked.
References
[1] Organic Syntheses, 2002, vol. 79, p. 196 - 196
[2] Patent: US2003/187014, 2003, A1
[3] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1958, vol. 148, p. 481,488
[4] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 7, p. 2151 - 2163
[5] European Journal of Medicinal Chemistry, 1994, vol. 29, # 10, p. 743 - 751
2-Amino-3-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Amino-3-fluorobenzoic acid manufacturers
- Product
- 2-amino-3-fluorobenzoic acid 825-22-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-19
- Product
- 2-Amino-3-fluorobenzoic acid 825-22-9
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 10 Tons
- Release date
- 2025-06-24
- Product
- 2-Amino-3-fluorobenzoic acid 825-22-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-12