ChemicalBook > CAS DataBase List > AC-LEHD-AFC

AC-LEHD-AFC

Product Name
AC-LEHD-AFC
CAS No.
210345-03-2
Chemical Name
AC-LEHD-AFC
Synonyms
AC-LEHD-AFC;Ac-LEHD-AFC TFA salt;AC-LEU-GLU-HIS-ASP-AFC;CASPASE-9 SUBSTRATE I, FLUOROGENIC;CASPASE 9 SUBSTRATE 1F, FLUOROGENIC;Caspase 9 Substrate 1f, fluorogenic - 5 mg;AC-LEU-GLU-HIS-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN;N-ACETYL-LEU-GLU-HIS-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;N-ACETYL-LEU-GLU-HIS-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN);N-ACETYL-LEU-GLU-HIS-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC
CBNumber
CB6377625
Molecular Formula
C33H38F3N7O11
Formula Weight
765.69
MOL File
210345-03-2.mol
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AC-LEHD-AFC Property

Boiling point:
1211.9±65.0 °C(Predicted)
Density 
1.457±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO/DMF: 20 mM
form 
powder
pka
4.07±0.10(Predicted)
color 
white
Water Solubility 
Soluble to 1 mg/ml in water
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
218765
Product name
Caspase-9 Substrate I, Fluorogenic
Purity
A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).
Packaging
1MG
Price
$135
Updated
2025/07/31
Sigma-Aldrich
Product number
A5845
Product name
N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin
Purity
≥95% (HPLC), powder
Packaging
5mg
Price
$245
Updated
2025/07/31
Sigma-Aldrich
Product number
218765
Product name
Caspase-9 Substrate I, Fluorogenic
Purity
A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).
Packaging
5MG
Price
$371
Updated
2025/07/31
Cayman Chemical
Product number
17051
Product name
Ac-LEHD-AFC
Purity
≥95%
Packaging
1mg
Price
$40
Updated
2021/12/16
Cayman Chemical
Product number
17051
Product name
Ac-LEHD-AFC
Purity
≥95%
Packaging
5mg
Price
$120
Updated
2021/12/16
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AC-LEHD-AFC Chemical Properties,Usage,Production

Uses

Ac-LEHD-AFC Trifluoroacetic Acid Salt is a fluorogenic substrate that is cleaved by caspases (4,5 and 9). This activity is quantified by fluorescent detection of free AFC. Caspase-9 activation is critical for intrinsic cell death.

Biological Activity

Fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.

AC-LEHD-AFC Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-LEHD-AFC Suppliers

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210345-03-2, AC-LEHD-AFCRelated Search:

Z-PHE-DL-ALA-FLUOROMETHYLKETONE AC-YVAD-PNA CASPASE INHIBITOR3 AC-VEID-AMC Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Z-YVAD-AFC ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL AC-VDVAD-CHO AC-DEVD-AFC PAC1 AC-DEVD-CHO AC-LEU-GLU-THR-ASP-AFC AC-VDVAD-PNA Z-VAD-FMK AC-LEU-GLU-HIS-ASP-AMC AC-LEHD-AFC

  • N-ACETYL-LEU-GLU-HIS-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
  • N-ACETYL-LEU-GLU-HIS-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
  • N-ACETYL-LEU-GLU-HIS-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC
  • AC-LEU-GLU-HIS-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN
  • AC-LEU-GLU-HIS-ASP-AFC
  • AC-LEHD-AFC
  • CASPASE-9 SUBSTRATE I, FLUOROGENIC
  • CASPASE 9 SUBSTRATE 1F, FLUOROGENIC
  • L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- (9CI)
  • 4-[(2-acetamido-4-methylpentanoyl)amino]-5-[[1-[[3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
  • Ac-LEHD-AFC TFA salt
  • Caspase 9 Substrate 1f, fluorogenic - 5 mg
  • 210345-03-2
  • C33H38F3N7O11
  • C33H38O11N7F3
  • Caspases/Apoptosis
  • peptide
  • ADC Linker