ChemicalBook > CAS DataBase List > 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE

3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE

Product Name
3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE
CAS No.
186611-55-2
Chemical Name
3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE
Synonyms
SU 4313;SU 4313, 10 mM in DMSO;SU4313 SU-4313 SU 4313;3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE;(3e)-3-(4-isopropylbenzylidene)-1,3-dihydro-2h-indol-2-one;1,3-Dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-2H-indol-2-one;2H-Indol-2-one,1,3-dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-
CBNumber
CB6379043
Molecular Formula
C18H17NO
Formula Weight
263.33
MOL File
186611-55-2.mol
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3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE Property

form 
Yellow crystals.
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC10602
Product name
SU4313
Purity
>98%
Packaging
1g
Price
$1620
Updated
2021/12/16
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3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE Chemical Properties,Usage,Production

Uses

SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation[1].

IC 50

PDGFR: 14.5 μM (IC50); FLK-1: 18.8 μM (IC50); EGFR: 11 μM (IC50); HER2: 16.9 μM (IC50); IGF-1R: 8.0 μM (IC50)

References

[1] Peng Cho Tang, et al. Indolinone compounds for the treatment of disease. WO1996040116A1.

3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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186611-55-2, 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONERelated Search:

SU 5214 SUN11602 SU 4942 SU 11274 SU 5205 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide SU 4312 4-ISOPROPYLCINNAMALDEHYDE 4-ISO-PROPYL STYRENE N,3-DIPHENYLACRYLAMIDE 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE

  • SU 4313
  • 2H-Indol-2-one,1,3-dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-
  • 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE
  • SU4313 SU-4313 SU 4313
  • (3e)-3-(4-isopropylbenzylidene)-1,3-dihydro-2h-indol-2-one
  • 1,3-Dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-2H-indol-2-one
  • SU 4313, 10 mM in DMSO
  • 186611-55-2
  • C18H17NO
  • Indoles and derivatives