4-Amino-3-nitropyridine

Product Name: 4-Amino-3-nitropyridine
CAS No.: 1681-37-4
Chemical Name: 4-Amino-3-nitropyridine
Synonyms: TIMTEC-BB SBB005533;3-Nitropyridin-4-amin;3-NITROPYRIDIN-4-AMINE;3-NITRO-4-PYRIDINAMINE;4-AMINO-3-NITROPYRIDINE;3-NITRO-4-AMINOPYRIDINE;4-aMine-3-nitropyridine;4-Pyridinamine, 3-nitro-;(3-nitro-4-pyridyl)amine;3-NITRO-PYRIDIN-4-YLAMINE
CBNumber: CB6398486
Molecular Formula: C5H5N3O2
Formula Weight: 139.11
MOL File: 1681-37-4.mol

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4-Amino-3-nitropyridine Property

Melting point:: 203-207 °C (lit.)
Boiling point:: 255.04°C (rough estimate)
Density: 1.4551 (rough estimate)
refractive index: 1.5900 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Crystalline Powder
pka: 5.02±0.12(Predicted)
color: Yellow
Water Solubility: Insoluble in water.
BRN: 383710
InChI: InChI=1S/C5H5N3O2/c6-4-1-2-7-3-5(4)8(9)10/h1-3H,(H2,6,7)
InChIKey: IUPPEELMBOPLDJ-UHFFFAOYSA-N
SMILES: C1=NC=CC(N)=C1[N+]([O-])=O
CAS DataBase Reference: 1681-37-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
RIDADR: UN2811
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 646962
Product name: 4-Amino-3-nitropyridine
Purity: 97%
Packaging: 10g
Price: $282
Updated: 2025/07/31

Sigma-Aldrich

Product number: 646962
Product name: 4-Amino-3-nitropyridine
Purity: 97%
Packaging: 1g
Price: $39.4
Updated: 2023/06/20

TCI Chemical

Product number: A2260
Product name: 4-Amino-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $76
Updated: 2025/07/31

TCI Chemical

Product number: A2260
Product name: 4-Amino-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $302
Updated: 2025/07/31

TRC

Product number: A622738
Product name: 4-Amino-3-nitropyridine
Packaging: 500mg
Price: $75
Updated: 2021/12/16

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4-Amino-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

4-Amino-3-nitropyridine is used as a pharmaceutical intermediate.

Synthesis

504-24-5

1681-37-4

The general procedure for the synthesis of 4-amino-3-nitropyridine from 4-aminopyridine was as follows: pyridin-4-amine (5.0 g, 50.0 mmol) was dissolved in concentrated sulfuric acid (20 mL) under ice-bath conditions. Keeping the reaction temperature in the range of 0-10 °C, fuming nitric acid (2.5 mL) was added slowly and dropwise. After the dropwise addition, the reaction was continued to be stirred at 0-10 °C for 5 hours. Subsequently, the reaction mixture was warmed to room temperature and heated at 90°C for 3 hours. After the reaction was completed, the mixture was continued to be stirred at room temperature overnight. The reaction mixture was slowly poured into ice water and the pH was adjusted with ammonia to 7. The resulting precipitate was collected by filtration and dried under reduced pressure to afford 4-amino-3-nitropyridine as a yellow solid (5.1 g, 70% yield). Mass spectrometry analysis showed [M + H]+ m/z: 140.04.

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2621 - 2631
[2] Synthesis, 2011, # 5, p. 794 - 806
[3] Chemistry of Heterocyclic Compounds, 2015, vol. 51, # 2, p. 203 - 204
[4] Khim. Geterotsikl. Soedin., 2015, vol. 51, # 2, p. 203 - 204,2
[5] Patent: WO2017/168333, 2017, A1. Location in patent: Page/Page column 16

4-Amino-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-CHLORO-PYRIDINE-3,4-DIAMINE 2-Chloro-3,4-diaminopyridine 4-ACETAMIDO-3-AMINOPYRIDINE 2-METHYLIMIDAZO[4,5-C]PYRIDINE 3,4-Diaminopyridine 4-ACETAMIDO-3-NITROPYRIDINE

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4-Amino-3-nitropyridine Suppliers

Americas 1 Belgium 2 Canada 1 China 244 Europe 3 France 1 Germany 10 India 35 Japan 3 Jordan 1 Poland 1 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 69 Global 397

Nan Jing Dirise Chemcial Co.,LTD

Tel: 025-52161033 15312098939
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Country: China
ProdList: 583
Advantage: 64

Shandong Meiao Huawei Technology Co., LTD

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Email: yuhongmeng@mayowell.com
Country: China
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Fax: 86-21-61259102
Email: market03@meryer.com
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INTATRADE GmbH

Tel: +49 3493/605464
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Email: sales@intatrade.de
Country: Germany
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future industrial shanghai co., ltd

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Chembest Research Laboratories Limited

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Alfa Aesar

Tel: 400-6106006
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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Ark Pharm, Inc.

Tel: 847-367-3680
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Country: United States
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View Lastest Price from 4-Amino-3-nitropyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Amino-3-nitropyridine 1681-37-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Dideu Industries Group Limited

Product: 4-Amino-3-nitropyridine 1681-37-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Amino-3-nitropyridine 1681-37-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

1681-37-4, 4-Amino-3-nitropyridineRelated Search:

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(3-nitro-4-pyridyl)amine

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TIMTEC-BB SBB005533

3-NITROPYRIDIN-4-AMINE

3-NITRO-4-AMINOPYRIDINE

3-NITRO-4-PYRIDINAMINE

4-AMINO-3-NITROPYRIDINE

3-NITRO-PYRIDIN-4-YLAMINE

4-AMino-3-nitropyridine, 98% 1GR

4-Amino-3-nitropyridine ,98%

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1681-37-4

C5

Building Blocks

Heterocyclic Building Blocks

Pyridines

Boronic Acid

C5

Heterocyclic Building Blocks

Building Blocks/Intermediates

Pyridine Series

Pyridines derivates

Pyridine