STREPTOLYSIN O

Product Name: STREPTOLYSIN O
CAS No.: 98072-47-0
Chemical Name: STREPTOLYSIN O
Synonyms: STREPTOLYSIN O;Einecs 308-500-3;Streptococcus sp.;STREPTOLYSIN O REAGENT;STREPTOLYSIN O GAMMA-IRRADIATED;Hemolysins O, Streptococcus group A;STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES;Native Streptococcus pyogenes Streptolysin O
CBNumber: CB6407012
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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STREPTOLYSIN O Property

storage temp.: 2-8°C
solubility: H2O: soluble1mg/mL
form: lyophilized powder
color: white

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Safety

RIDADR: UN 2811PIH 6.1 / PGI
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S5265
Product name: Streptolysin O from Streptococcus pyogenes
Purity: lyophilized powder, Protein ~3?% by Lowry, 25,000-50,000?U/vial
Packaging: 25000units
Price: $240
Updated: 2024/03/01

Sigma-Aldrich

Product number: S0149
Product name: Streptolysin O from Streptococcus pyogenes
Purity: γ-irradiated
Packaging: 25000units
Price: $282
Updated: 2024/03/01

Sigma-Aldrich

Product number: SAE0089
Product name: Streptolysin O from Streptococcus pyogenes
Purity: ≥1,000,000?units/mg protein, recombinant, lyophilized powder, expressed in E. coli
Packaging: 100KU
Price: $206
Updated: 2023/06/20

Usbiological

Product number: 506381
Product name: Streptolysin O
Packaging: 1mg
Price: $472
Updated: 2021/12/16

Usbiological

Product number: 506382
Product name: Streptolysin O
Packaging: 1mg
Price: $472
Updated: 2021/12/16

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STREPTOLYSIN O Chemical Properties,Usage,Production

Uses

Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Uses

Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.

General Description

Streptolysin O (SLO) is an immunogenic, oxygen-labile toxin, hemolytic exotoxin which is reversibly activated by dithiothreitol. ^[1] It is released into the extracellular medium along with other toxins, including streptolysin S, during the growth of most strains of group A and many strains of groups C and G Streptococci.^[1,2] SLO and Streptolysin S differ from each other in that SLO is immunogenic and oxygen-labile while Streptolysin S is oxygen-stable, nonimmunogenic and only active when associated with a carrier protein.^[3] The hemolytic activity of SLO is mediated by formation of multimeric nanopores in cholesterol containing lipid membranes.

SLO may be used for cell permeabilization or hemolysis. The susceptibility of hemolysis by SLO varies significantly for erythrocytes from different animal species.^[1] Permeabilization of cells using SLO has been performed on multiple cell types and for various applications. For instance it has been used to introduce antisense oligonucleotides into cultured eukaryotic cells;^[3] to investigate the effect of guanine nucleotide analogues on phosphatidylinositol metabolism and protein kinase C (PKC) activation in live human T lymphocytes;^[4] to monitor cholesterol oxidation within a membrane lipid bilayer; ^[5]and to label proteins inside living cells using external fluorophores.^[6]

Biochem/physiol Actions

This product is produced by recombinant expression in Escherichia coli and contains the complete native protein sequence of SLO (Uniport ID: P0DF96 aa 34-571) without any added purification tags and has calculated molecular weight of 60,144 Dalton. The material is lyophilized from a solution containing 20 mM Sodium Hepes pH 7.5, 150 mM Sodium Chloride and 2 mM EDTA.

STREPTOLYSIN O Preparation Products And Raw materials

Raw materials

Preparation Products

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STREPTOLYSIN O Suppliers

China 26 Switzerland 1 United States 7 Global 34

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98072-47-0, STREPTOLYSIN ORelated Search:

Cupric acetylacetonate Tosylmethyl isocyanide Ethyl isocyanoacetate SALCOMINE N-BUTYLISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Ferric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL Aluminum acetylacetonate COBALT(II) ACETYLACETONATE

STREPTOLYSIN O

STREPTOLYSIN O REAGENT

Hemolysins O, Streptococcus group A

STREPTOLYSIN O GAMMA-IRRADIATED

STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES

Einecs 308-500-3

Native Streptococcus pyogenes Streptolysin O

Streptococcus sp.

98072-47-0

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