SC-560

Product Name: SC-560
CAS No.: 188817-13-2
Chemical Name: SC-560
Synonyms: SC SC;SC-560;CS-1042;5-(4-Chlorophenyl);SC-560;SC 560;SC560;SC-560 Assay Reagent;SC-560 - CAS 188817-13-2 - Calbiochem;Cyclooxygenase,SC 560,inhibit,Inhibitor,SC-560,COX;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-TRIFLUOROMETHYLPYRAZOLE;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
CBNumber: CB6409526
Molecular Formula: C17H12ClF3N2O
Formula Weight: 352.74
MOL File: 188817-13-2.mol

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SC-560 Property

Melting point:: 63 °C
Boiling point:: 440.6±45.0 °C(Predicted)
Density: 1.33
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: Off-white solid
pka: -3?+-.0.10(Predicted)
color: White to Light yellow to Light orange

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S2064
Product name: SC-560
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $247
Updated: 2024/03/01

Sigma-Aldrich

Product number: 565610
Product name: SC-560
Packaging: 5mg
Price: $168
Updated: 2022/05/15

TCI Chemical

Product number: C3572
Product name: SC-560
Packaging: 25MG
Price: $95
Updated: 2024/03/01

TCI Chemical

Product number: C3572
Product name: SC-560
Packaging: 100MG
Price: $235
Updated: 2024/03/01

Cayman Chemical

Product number: 70340
Product name: SC-560
Purity: ≥98%
Packaging: 1mg
Price: $19
Updated: 2024/03/01

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SC-560 Chemical Properties,Usage,Production

Uses

5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole is used as a cyclooxygenase inhibitors on the angiogenesis and apoptosis.

Uses

SC-560 has been used as a cyclooxygenase-1 (COX-1) inhibitor to study its effects on prostaglandin E-2 (PGE2) signaling in ciliogenesis in zebrafish embryos. It has also been used as a selective inhibitor of COX-1 to study its role in PM10-induced endothelial dysfunction.

Definition

ChEBI: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclo xygenase (COX) inhibitors, SC-560 is selective for COX-1.

Biological Activity

Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.009 and 6.3 μ M for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B 2 , gastric PGE 2 and dermal PDE 2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo . Orally active.

Biochem/physiol Actions

SC-560 (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole) is a non-steroidal anti-inflammatory drug (NSAID). It is a lipophilic, diaryl heterocyclic compound. SC-560 acts as an effective antiviral agent against hepatitis C virus (HCV). It also has a potential to hinder prostaglandin E2 synthesis in neurons at nanomolar concentrations.

in vitro

preincubation of cox-1 with sc-560 inhibited the conversion of arachidonic acid to pge2 in a concentration-dependent manner [1]. sc-560 was necessary to sustain a reduced basal level of pgi2 for an extended period. sc-560 inhibits cell proliferation and accelerates apoptosis which results in attenuated tumor growth [2].

in vivo

oral dosing with either 10 or 30 mg/kg sc-560 1 hr before assay completely inhibited cox-1-derived platelet thromboxane b2, gastric pge2, and dermal pge2 production [1]. sc-560 can suppress ovarian surface epithelial tumor growth. tumor growth was suppressed in allografted mice treated with sc-560 for a longer period, but the reduction in tumor growth was less dramatic than the short-term treated [2].

IC 50

0.009 μm for cox-1; 6.3 μm for cox-2

storage

Store at +4°C

References

[1] daikoku t, wang d, tranguch s, morrow jd, orsulic s, dubois rn, dey sk. cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. cancer res. 2005 may 1;65(9):3735-44.
[2] christopher j. smith, yan zhang, carol m. koboldt, jerry muhammad, ben s. zweifel, alex shaffer, john j. talley, jaime l. masferrer, karen seibert, peter c. isakson. pharmacological analysis of cyclooxygenase-1 in inflammation. proc natl acad sci u s a. 1998 oct 27; 95(22): 13313–13318.

SC-560 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC-560 Suppliers

Americas 1 CHINA 78 Europe 1 Germany 1 India 2 Japan 1 Switzerland 2 United Kingdom 4 United States 18 USA 1 Global 109

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View Lastest Price from SC-560 manufacturers

Career Henan Chemical Co

Product: SC-560 188817-13-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

188817-13-2, SC-560Related Search:

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SC-560

5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-TRIFLUOROMETHYLPYRAZOLE

SC-560 Assay Reagent

1H-Pyrazole, 5-(4-chlorophenyl)-1-(4-Methoxyphenyl)-3-(trifluoroMethyl)-

5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole

5-(4-Chlorophenyl)

SC-560 - CAS 188817-13-2 - Calbiochem

CS-1042

SC-560;SC 560;SC560

SC SC

Cyclooxygenase,SC 560,inhibit,Inhibitor,SC-560,COX

188817-13-2

18817-13-2

C17H12ON2ClF3