ChemicalBook > CAS DataBase List > m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate

m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate

Product Name
m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate
CAS No.
882366-16-7
Chemical Name
m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate
Synonyms
SBI115;SBI 115;SBI-115;SBI-115 ，S6806;SBI-115, 10 mM in DMSO;SBI-115; SBI 115; SBI115;m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate;3-Methylphenyl 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylate;4-Pyrimidinecarboxylic acid, 5-chloro-2-(ethylsulfonyl)-, 3-methylphenyl ester;G protein-coupled Bile Acid Receptor 1,GPCR19,TGR5,SBI115,GPBAR1,Inhibitor,SBI-115,SBI 115,G-protein coupled receptor 19,inhibit
CBNumber
CB64101730
Molecular Formula
C14H13ClN2O4S
Formula Weight
340.78
MOL File
882366-16-7.mol
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m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate Property

Boiling point:
529.7±60.0 °C(Predicted)
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:109.0(Max Conc. mg/mL);319.86(Max Conc. mM)
pka
-7.73±0.49(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0043229
Product name
SBI-115
Purity
99.51%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0043229
Product name
SBI-115
Purity
99.51%
Packaging
10mg
Price
$550
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611911
Product name
SBI-115
Purity
>98%
Packaging
100mg
Price
$690.2
Updated
2021/12/16
ChemScene
Product number
CS-0043229
Product name
SBI-115
Purity
99.51%
Packaging
25mg
Price
$1100
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611911
Product name
SBI-115
Purity
>98%
Packaging
250mg
Price
$1356.6
Updated
2021/12/16
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m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate Chemical Properties,Usage,Production

Uses

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5[1].

References

[1] Masyuk TV, et al. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct; 66(4):1197-1218. DOI:10.1002/hep.29284

m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate Suppliers

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882366-16-7, m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylateRelated Search:

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  • m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate
  • SBI 115
  • SBI115
  • SBI-115
  • SBI-115; SBI 115; SBI115
  • 4-Pyrimidinecarboxylic acid, 5-chloro-2-(ethylsulfonyl)-, 3-methylphenyl ester
  • 3-Methylphenyl 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylate
  • G protein-coupled Bile Acid Receptor 1,GPCR19,TGR5,SBI115,GPBAR1,Inhibitor,SBI-115,SBI 115,G-protein coupled receptor 19,inhibit
  • SBI-115, 10 mM in DMSO
  • SBI-115 ，S6806
  • 882366-16-7