ChemicalBook > CAS DataBase List > 4-Fluoroacetophenone

4-Fluoroacetophenone

Product Name
4-Fluoroacetophenone
CAS No.
403-42-9
Chemical Name
4-Fluoroacetophenone
Synonyms
1-(4-Fluorophenyl)ethan-1-one;1-(4-FLUOROPHENYL)ETHANONE;4-Fluoracetophenon;P-FLUOROACETOPHENONE;4'-FLUOROACETOPHENONE;p-Fluoro;AKOS BBS-00003234;4-FLUOROCETOPHENONE;Fluoroacetophenone3;4-FLUOROACETOPHENONE
CBNumber
CB6419110
Molecular Formula
C8H7FO
Formula Weight
138.14
MOL File
403-42-9.mol
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4-Fluoroacetophenone Property

Melting point:
4 °C
Boiling point:
77-78 °C10 mm Hg(lit.)
Density 
1.143 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.511(lit.)
Flash point:
160 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Ethyl Acetate
form 
Liquid
Specific Gravity
1.138
color 
Clear colorless to slightly yellow
BRN 
386013
InChIKey
ZDPAWHACYDRYIW-UHFFFAOYSA-N
CAS DataBase Reference
403-42-9(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(4-fluorophenyl)-(403-42-9)
EPA Substance Registry System
4'-Fluoroacetophenone (403-42-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-23
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29147090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F3207
Product name
4′-Fluoroacetophenone
Purity
99%
Packaging
25g
Price
$54.4
Updated
2024/03/01
Sigma-Aldrich
Product number
F3207
Product name
4′-Fluoroacetophenone
Purity
99%
Packaging
100g
Price
$94.6
Updated
2024/03/01
TCI Chemical
Product number
F0261
Product name
4'-Fluoroacetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$41
Updated
2024/03/01
TCI Chemical
Product number
F0261
Product name
4'-Fluoroacetophenone
Purity
>98.0%(GC)
Packaging
500g
Price
$486
Updated
2024/03/01
Alfa Aesar
Product number
A13950
Product name
4'-Fluoroacetophenone, 99%
Packaging
25g
Price
$32.8
Updated
2024/03/01
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4-Fluoroacetophenone Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

4-Fluoroacetophenone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

4’-Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products.

Uses

4’Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products.

Synthesis


General procedure: Oximes (1.0 mmol), Amberlyst-15 (0.02 g), FPA53-NO2(0.02 g), and solvent (1.5 mL) were introduced into a 25-cm-high, 90-mL autoclave with a glass tube inside equipped with magnetic stirrer (Scheme 2). Then the autoclave was charged with oxygen to 0.1 MPa. The reaction mixture was stirred at desirable temperature for special time. Progress of the reaction was monitored by thin-layer chromatography (TLC) or gas chromatography (GC). After the reaction, the resin (Amberlyst-15 and FPA53-NO2) was separated from the reaction mixture by filtration and extracted with 3 mL CH3CN (2 1.5 ml). The solvent was removed under reduced pressure. The residue was further purified by column chromatography on silica gel (300 mesh) with hexane/ethyl acetate to give the corresponding carbonyl compounds.

4-Fluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-FLUOROPHENYL)-1H-INDOLE-3-CARBALDEHYDE 4'-PIPERAZINOACETOPHENONE 2-(4-FLUOROBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE ETHYL 2-AMINO-4-(4-FLUOROPHENYL)THIOPHENE-3-CARBOXYLATE 4-(4-Fluorophenyl)pyrimidine-2-thiol 4-Fluorophenylacetylene 4'-Phenoxyacetophenone 1-(4-FLUOROPHENYL)ETHYLAMINE 5-(4-FLUOROPHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE 2-Bromo-4'-fluoroacetophenone 6-(4-FLUOROPHENYL)INDOLE 4-FLUOROBENZOYLACETONITRILE 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
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4-Fluoroacetophenone Suppliers

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View Lastest Price from 4-Fluoroacetophenone manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
4-Fluoroacetophenone 403-42-9
Price
US $300.00/Kg/Drum
Min. Order
1KG
Purity
99% HPLC
Supply Ability
500KG/WEEK
Release date
2021-06-02
Hebei Weibang Biotechnology Co., Ltd
Product
4-Fluoroacetophenone 403-42-9
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-23
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Fluoroacetophenone 403-42-9
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20

403-42-9, 4-FluoroacetophenoneRelated Search:

4'-Methylacetophenone 4-Nitroacetophenone 4'-(Trifluoromethyl)acetophenone L-PICEIN 2-Bromoacetophenone Acetophenone 3-Nitroacetophenone 4'-Hydroxyacetophenone 4'-Fluoropropiophenone 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE 4-Dechloro-4-(4-chlorophenyl) Haloperidol Decanoate Haloperidol Lauroate 4-Defluoro-2-fluoro Haloperidol Decanoate 4-[4-(4-Chlorophenyl)-4-hydroxypiperidine]-4-defluorohaloperidol Decanoate Haloperidol Octanoate 4-Dechloro-4-(3-chlorophenyl) Haloperidol Decanoate ODANWSUZWFYXTO-UHFFFAOYSA-N 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate

  • Acetophenone, 4'-fluoro-
  • para-Fluoroacetophenone
  • P-FLUOROACETOPHENONE
  • 4-FLUOROCETOPHENONE
  • 4'-FLUOROACETOPHENONE
  • 4-FLUOROACETOPHENONE
  • AKOS BBS-00003234
  • 1-(4-Fluorophenyl)ethan-1-one
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  • Fluoroacetophenone3
  • 4'-Fluoroacetophenone 1-(4-Fluorophenyl)ethan-1-one 1-(4-Fluorophenyl)ethanone
  • 4-Fluoroacetophenone,99%
  • LABOTEST-BB LT01148215
  • 1-(4-FLUOROPHENYL)ETHANONE
  • p-Fluoro
  • 4'-Fluoroacetophenone 99%
  • Ethanone, 1-(4-fluorophenyl)-
  • p-Fluorophenyl methyl ketone
  • 1-(4-fluorophenyl)-ethanon
  • 1-Acetyl-4-fluorobenzene
  • 4-Acetylphenyl fluoride
  • Methyl 4-fluorophenyl ketone
  • 4-Acetylfluorobenzene
  • 4-Fluorophenyl Methyl ketone
  • 4-Fluorophenylethanal
  • Methyl 4-fluorophenyl
  • Of Fluoroacetophenone
  • 1-(4-Fluorophenyl)ethan-1-one, 1-(4-Fluorophenyl)-1-oxoethane
  • The fluorine acetophenone
  • 4'-Fluoroacetophenone&gt
  • 4'-Fluoroacetophenone, 99%, for synthesis
  • Haloperidol Decanoate EP Impurity L
  • Haloperidol Decanoate Impurity 12（Haloperidol Decanoate EP Impurity L）
  • Lidocaine Pharmaceutical Drugs
  • 4-Fluoracetophenon
  • Bromperidol decanoate EP Impurity L
  • TIANFU-CHEM 4-Fluoroacetophenone
  • 4-Fluoroacetophenone pure, 98%
  • Haloperidol EP Impurity L
  • Haloperidol Decanoate Impurity L
  • 4-FLOURO ACETOPHENONE
  • 4'-Fluoroacetophenone
  • 403-42-9
  • C7 to C8
  • Carbonyl Compounds
  • Building Blocks
  • Organic Building Blocks
  • Ketones
  • Adehydes, Acetals & Ketones
  • Fluorine Compounds
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
  • Acetophenone series
  • Benzenes
  • Aromatic Acetophenones & Derivatives (substituted)
  • Organics
  • ketone