ChemicalBook > CAS DataBase List > Diethyl azodicarboxylate

Diethyl azodicarboxylate

Product Name
Diethyl azodicarboxylate
CAS No.
1972-28-7
Chemical Name
Diethyl azodicarboxylate
Synonyms
DEAD;DAD;(E)-di-tert-butyl diazene-1,2-dicarboxylate;Diethyl diazene-1,2-dicarboxylate;(E)-diethyl diazene-1,2-dicarboxylate;Diethoxycarbonyldiazene;DiethylAzidoCarboxylate;diethyl azodicarboxylate solution;AZODICARBOXYLIC ACID DIETHYL ESTER;Ethyl (NE)-N-ethoxycarbonyliminocarbamate
CBNumber
CB6432076
Molecular Formula
C6H10N2O4
Formula Weight
174.15
MOL File
1972-28-7.mol
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Diethyl azodicarboxylate Property

Melting point:
6°C
Boiling point:
106°C (13 mmHg)
Density 
1.106
refractive index 
n20/D 1.47
Flash point:
85°C
storage temp. 
2-8°C
solubility 
Miscible with dichloromethane, diethyl ether and toluene.
form 
liquid
color 
Clear, orange
Sensitive 
Air Sensitive
BRN 
908662
Stability:
Stable, but may explode if heated under confinement. May be shock sensitive. Decomposes vigorously if heated above 100 C. Incompatible with strong acids, strong bases, strong oxidizing agents, strong reducing agents. Light sensitive.
InChI
InChI=1S/C6H10N2O4/c1-3-11-5(9)7-8-6(10)12-4-2/h3-4H2,1-2H3
InChIKey
FAMRKDQNMBBFBR-FPLPWBNLSA-N
SMILES
N(C(OCC)=O)=NC(OCC)=O
CAS DataBase Reference
1972-28-7(CAS DataBase Reference)
NIST Chemistry Reference
Diethyl azo diformate(1972-28-7)
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Safety

Hazard Codes 
F,Xn,Xi
Risk Statements 
5-11-20-36/37/38-48/20-63-65-67-48/20/22-40-20/22-20/21/22-10
Safety Statements 
26-36/37-62-47-36-35
RIDADR 
UN 3233 4.1
WGK Germany 
3
F 
9
Hazard Note 
Toxic/Irritant/Flammable
HazardClass 
6.1
PackingGroup 
III
HS Code 
29270000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H242Heating may cause a fire

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P331Do NOT induce vomiting.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
563110
Product name
Diethyl azodicarboxylate solution
Purity
40 wt. % in toluene
Packaging
25g
Price
$77.4
Updated
2025/07/31
Sigma-Aldrich
Product number
563110
Product name
Diethyl azodicarboxylate solution
Purity
40 wt. % in toluene
Packaging
100g
Price
$254
Updated
2025/07/31
Usbiological
Product number
009443
Product name
Diethyl Azodicarboxylate
Packaging
1g
Price
$403
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002335
Product name
DIETHYL AZODICARBOXYLATE
Purity
95.00%
Packaging
100G
Price
$2819.36
Updated
2021/12/16
Matrix Scientific
Product number
139948
Product name
Diethyl azodicarboxylate
Purity
95%+
Packaging
1g
Price
$101
Updated
2021/12/16
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Diethyl azodicarboxylate Chemical Properties,Usage,Production

Chemical Properties

Clear orange to orange-red liquid

Uses

A fluorescent CDK inhibitor for treatment of cancer

Uses

Reactant for preparation of:

  • Immunostimulants α-Galactosylceramides
  • Cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases
  • Bisubstrate inhibitors with molecular recognition at the active site of catechol-O-methyltransferase
  • Derivatives of F200 and S383 with cannabinoid CB1 receptor binding activities
  • Aza-β-lactams via NHC-catalyzed [2 + 2] cycloaddition with ketenes

Reagent for:
  • Annulation of N-protected imines
  • α-thiocyanation of enolizable ketones with ammonium thiocyanate
  • Diels-Alder reactions

General Description

DOT Special Approval Submission is Under Review. Availability is Estimated as March 2012.

Purification Methods

Dissolve DEAD in toluene, wash it with 10% NaHCO3 till neutral (may require several washes if too much hydrolysis had occurred: check IR for OH bands), then wash with H2O (2x), dry over Na2SO4, filter, evaporate the toluene and distil it through a short Vigreux column (p 11) at as high a vacuum as possible. The main portion boils at 107-111o/15mm. Since it is likely to explode, use an oil bath for heating the still and all operations should be carried -out behind an adequate shield. [Rabjohn Org Synth Coll Vol III 375 1955, see Kauer Org Synth Coll Vol IV 412 1963]. [Beilstein 3 III 233.] It is commercially available as a 40% solution in toluene. This reagent is useful in the Mitsunobu reaction [Mitsunobu Synthesis 1 1981, Gennari et al. J Am Chem Soc 108 6394 1986, Evans et al. J Am Chem Soc 108 6394 1986, Hughes Org React 42 335 1992, Dodge et al. Org Synth 73 110 1996, Hughes Org Prep Proc Int 28 127 1996, Ferguson & Marcelle J Am Chem Soc 128 4576 2006; see also di-tert-butyl azodicarboxylate above and DIAD below]. § A polystyrene supported DEAD version is commercially available with a loading of ~1.2mmol/g.

Diethyl azodicarboxylate Preparation Products And Raw materials

Raw materials

DIETHYL HYDRAZODICARBOXYLATE

Preparation Products

Zidovudine 5-Methylpyridine-2,3-dicarboxylic acid 1,1-Cyclobutanedicarboxylic acid 2,3-Quinoline dicarboxylic acid 1-Boc-2-Methylpiperazine 1-METHYL-PROP-2-YNYLAMINE 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE 4-((1-METHYLPIPERIDIN-3-YL)METHOXY)-3,5-DICHLOROBENZENAMINE BUT-3-YN-1-AMINE
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View Lastest Price from Diethyl azodicarboxylate manufacturers

Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
Product
Diethyl azodicarboxylate 1972-28-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1
Release date
2025-09-26
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Diethyl azodicarboxylate 1972-28-7
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000Ton
Release date
2024-08-09
Hebei Chuanghai Biotechnology Co., Ltd
Product
Diethyl azodicarboxylate 1972-28-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

1972-28-7, Diethyl azodicarboxylateRelated Search:

BUTYL OLEATE Diethyl phthalate Diisopropyl azodicarboxylate Ethyl formate Diethyl malonate Dimethyl 2,2'-azobis(2-methylpropionate) Triethyl orthoformate Di-tert-Butyl azodicarboxylate Urethane Bis(4-chlorobenzyl) azodicarboxylate Dibenzyl azodicarboxylate Methyl acrylate Dimethyl succinate Tris(trimethylsilyl)phosphate 1,1'-(Azodicarbonyl)-dipiperidine PIPERAZINE DIHYDROCHLORIDE N,N,N',N'-Tetramethylazodicarboxamide AZODICARBOXYLIC BISMORPHOLIDE

  • Diazenedicarboxylic acid, diethyl ester
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  • Diethylazodicarboxylate97%
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  • DAD
  • Diethyl azodicarboxylate, 94%, balance up to 5% dichloromethane
  • DIETHYLAZODICARBOXYIATE
  • Diethyl azidoformate
  • Ethyl (NE)-N-ethoxycarbonyliminocarbamate
  • Diethyl azodicarboxylate ,99%
  • Diethyl azodicarboxylate [40% in Toluene]
  • Diethyl azodicarboxylate ,40% in Toluene [40% in Toluene]
  • Diethyl Azodicarboxylate (40% in Toluene, ca. 2.2mol/L)
  • 1,2-Diazenebis(carboxylic acid ethyl) ester
  • Azobisformic acid diethyl ester
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  • Azodiformic acid diethyl ester
  • Diazenedicarboxylic acid diethyl
  • Diazenedicarboxylic acid, diethyl ester (9ci)
  • Einecs 217-821-7
  • Formic acid, azodi-, diethyl ester (8ci)
  • (DEAD) diethyl azodiformate
  • Diethyl azodicarboxy
  • Diethyl diazene-1,2-dicarboxylate 97%
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  • 1,2-Bis(ethoxycarbonyl) diazene
  • (E)-di-tert-butyl diazene-1,2-dicarboxylate
  • 1,2-Diazenedicarboxylic Acid 1,2-Diethyl Ester
  • Azodicarboxylic Acid Diethyl Ester DEAD
  • Azo twoforMic acid ethyl ester two
  • Azo 2 forMic acid diethyl ester
  • 1,2-Ethoxycarbonyl diazene solution
  • Diethoxycarbonyldiazene solution