Diethyl azodicarboxylate

Product Name: Diethyl azodicarboxylate
CAS No.: 1972-28-7
Chemical Name: Diethyl azodicarboxylate
Synonyms: DEAD;DAD;(E)-di-tert-butyl diazene-1,2-dicarboxylate;Diethyl diazene-1,2-dicarboxylate;(E)-diethyl diazene-1,2-dicarboxylate;Diethoxycarbonyldiazene;DiethylAzidoCarboxylate;diethyl azodicarboxylate solution;AZODICARBOXYLIC ACID DIETHYL ESTER;Ethyl (NE)-N-ethoxycarbonyliminocarbamate
CBNumber: CB6432076
Molecular Formula: C6H10N2O4
Formula Weight: 174.15
MOL File: 1972-28-7.mol

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Diethyl azodicarboxylate Property

Melting point:: 6°C
Boiling point:: 106°C (13 mmHg)
Density: 1.106
refractive index: n20/D 1.47
Flash point:: 85°C
storage temp.: 2-8°C
solubility: Miscible with dichloromethane, diethyl ether and toluene.
form: liquid
color: Clear, orange
Sensitive: Air Sensitive
BRN: 908662
Stability:: Stable, but may explode if heated under confinement. May be shock sensitive. Decomposes vigorously if heated above 100 C. Incompatible with strong acids, strong bases, strong oxidizing agents, strong reducing agents. Light sensitive.
InChI: InChI=1S/C6H10N2O4/c1-3-11-5(9)7-8-6(10)12-4-2/h3-4H2,1-2H3
InChIKey: FAMRKDQNMBBFBR-FPLPWBNLSA-N
SMILES: N(C(OCC)=O)=NC(OCC)=O
CAS DataBase Reference: 1972-28-7(CAS DataBase Reference)
NIST Chemistry Reference: Diethyl azo diformate(1972-28-7)

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Safety

Hazard Codes: F,Xn,Xi
Risk Statements: 5-11-20-36/37/38-48/20-63-65-67-48/20/22-40-20/22-20/21/22-10
Safety Statements: 26-36/37-62-47-36-35
RIDADR: UN 3233 4.1
WGK Germany: 3
F: 9
Hazard Note: Toxic/Irritant/Flammable
HazardClass: 6.1
PackingGroup: III
HS Code: 29270000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H242Heating may cause a fire

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P331Do NOT induce vomiting.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 563110
Product name: Diethyl azodicarboxylate solution
Purity: 40 wt. % in toluene
Packaging: 25g
Price: $75.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 563110
Product name: Diethyl azodicarboxylate solution
Purity: 40 wt. % in toluene
Packaging: 100g
Price: $246
Updated: 2024/03/01

Alfa Aesar

Product number: L19348
Product name: Diethyl azodicarboxylate, 97%
Packaging: 5g
Price: $33.3
Updated: 2021/12/16

Alfa Aesar

Product number: L19348
Product name: Diethyl azodicarboxylate, 97%
Packaging: 25g
Price: $92.6
Updated: 2021/12/16

Alfa Aesar

Product number: L19348
Product name: Diethyl azodicarboxylate, 97%
Packaging: 100g
Price: $274
Updated: 2021/12/16

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Diethyl azodicarboxylate Chemical Properties,Usage,Production

Chemical Properties

Clear orange to orange-red liquid

Uses

A fluorescent CDK inhibitor for treatment of cancer

Uses

Reactant for preparation of:

Immunostimulants α-Galactosylceramides
Cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases
Bisubstrate inhibitors with molecular recognition at the active site of catechol-O-methyltransferase
Derivatives of F200 and S383 with cannabinoid CB1 receptor binding activities
Aza-β-lactams via NHC-catalyzed [2 + 2] cycloaddition with ketenes

Reagent for:

Annulation of N-protected imines
α-thiocyanation of enolizable ketones with ammonium thiocyanate
Diels-Alder reactions

General Description

DOT Special Approval Submission is Under Review. Availability is Estimated as March 2012.

Purification Methods

Dissolve DEAD in toluene, wash it with 10% NaHCO3 till neutral (may require several washes if too much hydrolysis had occurred: check IR for OH bands), then wash with H2O (2x), dry over Na2SO4, filter, evaporate the toluene and distil it through a short Vigreux column (p 11) at as high a vacuum as possible. The main portion boils at 107-111o/15mm. Since it is likely to explode, use an oil bath for heating the still and all operations should be carried -out behind an adequate shield. [Rabjohn Org Synth Coll Vol III 375 1955, see Kauer Org Synth Coll Vol IV 412 1963]. [Beilstein 3 III 233.] It is commercially available as a 40% solution in toluene. This reagent is useful in the Mitsunobu reaction [Mitsunobu Synthesis 1 1981, Gennari et al. J Am Chem Soc 108 6394 1986, Evans et al. J Am Chem Soc 108 6394 1986, Hughes Org React 42 335 1992, Dodge et al. Org Synth 73 110 1996, Hughes Org Prep Proc Int 28 127 1996, Ferguson & Marcelle J Am Chem Soc 128 4576 2006; see also di-tert-butyl azodicarboxylate above and DIAD below]. § A polystyrene supported DEAD version is commercially available with a loading of ~1.2mmol/g.

Diethyl azodicarboxylate Preparation Products And Raw materials

Raw materials

DIETHYL HYDRAZODICARBOXYLATE

Preparation Products

Zidovudine 5-Methylpyridine-2,3-dicarboxylic acid 1,1-Cyclobutanedicarboxylic acid 2,3-Quinoline dicarboxylic acid 1-Boc-2-Methylpiperazine 1-METHYL-PROP-2-YNYLAMINE 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE 4-((1-METHYLPIPERIDIN-3-YL)METHOXY)-3,5-DICHLOROBENZENAMINE BUT-3-YN-1-AMINE

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Diethyl azodicarboxylate Suppliers

Belgium 1 Canada 1 China 326 Czech Republic 1 Europe 6 France 1 Germany 4 India 49 Japan 5 Poland 2 South Korea 2 Switzerland 4 United Kingdom 18 United States 37 Global 457

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Japan

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Fine Corporation

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Country: Japan
ProdList: 1427
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Wako Pure Chemical Industries, Ltd.

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Country: Japan
ProdList: 6819
Advantage: 80

Nacalai Tesque, Inc.

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Email: info-tech@nacalai.co.jp
Country: Japan
ProdList: 6046
Advantage: 75

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View Lastest Price from Diethyl azodicarboxylate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Diethyl azodicarboxylate 1972-28-7
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000Ton
Release date: 2024-08-09

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Diethyl azodicarboxylate 1972-28-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-04-24

Hebei Dangtong Import and export Co LTD

Product: Diethyl azodicarboxylate 1972-28-7
Price: US $120.00-115.00/kilograms
Min. Order: 10kilograms
Purity: 99%
Supply Ability: 100tons
Release date: 2023-03-01

1972-28-7, Diethyl azodicarboxylateRelated Search:

BUTYL OLEATE Diethyl phthalate Diisopropyl azodicarboxylate Ethyl formate Diethyl malonate Dimethyl 2,2'-azobis(2-methylpropionate) Triethyl orthoformate Di-tert-Butyl azodicarboxylate Urethane Methyl acrylate Dimethyl succinate Bis(4-chlorobenzyl) azodicarboxylate Dibenzyl azodicarboxylate Tris(trimethylsilyl)phosphate 1,1'-(Azodicarbonyl)-dipiperidine PIPERAZINE DIHYDROCHLORIDE N,N,N',N'-Tetramethylazodicarboxamide AZODICARBOXYLIC BISMORPHOLIDE

Diazenedicarboxylic acid, diethyl ester

Diethoxycarbonyldiazene

Diethyl (E)-1,2-diazenedicarboxylate

Diethyl diazodicarboxylate

dlethylazodicarboxylate

Ethyl azodicarboxylate

Formic acid, azodi-, diethyl ester

DIETHYL AZODIFORMATE

DEAD

AZODICARBOXYLIC ACID DIETHYL ESTER

Dimethyl azodicarboxyate

DIETHYL AZODICARBOXYLATE SOL., 38-40% IN METHYLENE CHLORIDE

DIETHYLAZODICARBOXYLATE 40 WT. % SOLUT&

DIETHYL AZODICARBOXYLATE SOLUTION, ~40% IN TOLUENE

DiethylAzidoCarboxylate

Pure Diethyl azodicarboxylate (40% solution in toluene)

diethyl azodicarboxylate solution

Diethylazodicarboxylate 97%

DIETHYLAZODICARBOXYLATE(DEAD)

diazocarboxylic acid ethyl ester

Diethylazodicarboxylate97%

Diethyl azodicarboxylate, GC 97%

DAD

Diethyl azodicarboxylate, 94%, balance up to 5% dichloromethane

DIETHYLAZODICARBOXYIATE

Diethyl azidoformate

Ethyl (NE)-N-ethoxycarbonyliminocarbamate

Diethyl azodicarboxylate ,99%

Diethyl azodicarboxylate [40% in Toluene]

Diethyl azodicarboxylate ,40% in Toluene [40% in Toluene]

Diethyl Azodicarboxylate (40% in Toluene, ca. 2.2mol/L)

1,2-Diazenebis(carboxylic acid ethyl) ester

Azobisformic acid diethyl ester

Azodicarboxylic acid diethyl

Azodiformic acid diethyl ester

Diazenedicarboxylic acid diethyl

Diazenedicarboxylic acid, diethyl ester (9ci)

Einecs 217-821-7

Formic acid, azodi-, diethyl ester (8ci)

(DEAD) diethyl azodiformate

Diethyl azodicarboxy

Diethyl diazene-1,2-dicarboxylate 97%

Diethyl azodicarboxylate solution (approx. 40% in toluene)

Diethyl??azodicarbo×ylate?（DEAD）

Diethyl diazene-1,2-dicarboxylate

Diethyl azodicarboxylate soluti

(E)-diethyl diazene-1,2-dicarboxylate

Diethyl azodicarboxylate, 40 wt.% solution in toluene

1,2-Ethoxycarbonyl diazene

Diethyl diazene-1,2-dicarboxylate, 40% solution in toluene

1,2-Bis(ethoxycarbonyl) diazene

(E)-di-tert-butyl diazene-1,2-dicarboxylate

1,2-Diazenedicarboxylic Acid 1,2-Diethyl Ester

Azodicarboxylic Acid Diethyl Ester DEAD

Azo twoforMic acid ethyl ester two

Azo 2 forMic acid diethyl ester

1,2-Ethoxycarbonyl diazene solution

Diethoxycarbonyldiazene solution