ChemicalBook > CAS DataBase List > 3-Fluoro-4-methoxyacetophenone
3-Fluoro-4-methoxyacetophenone
- Product Name
- 3-Fluoro-4-methoxyacetophenone
- CAS No.
- 455-91-4
- Chemical Name
- 3-Fluoro-4-methoxyacetophenone
- Synonyms
- Deracoxib 3-FMAP;BUTTPARK 153\33-60;Deracoxib Impurity 1;3-FLURO-4-METHOXYACETOPHENONE;3-FLUORO-4-METHOXYACETOPHENONE;3'-FLUORO-4-METHOXYACETOPHENONE;3'-Fluoro-4'-methoxyacetophenone;3’-Fluoro-4’-methyoxyacetophenone;3'-Fluoro-4'-methoxyacetophenone98%;3'-Fluoro-4'-methoxyacetophenone>
- CBNumber
- CB6479734
- Molecular Formula
- C9H9FO2
- Formula Weight
- 168.16
- MOL File
- 455-91-4.mol
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3-Fluoro-4-methoxyacetophenone Property
- Melting point:
- 92-94 °C(lit.)
- Boiling point:
- 147-148 °C20 mm Hg(lit.)
- Density
- 1.1410 (estimate)
- Flash point:
- 147-148°C/20mm
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
- BRN
- 2084062
- CAS DataBase Reference
- 455-91-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetophenone, 3'-fluoro-4'-methoxy-(455-91-4)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2914790090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 361836
- Product name
- 3′-Fluoro-4′-methoxyacetophenone
- Purity
- 99%
- Packaging
- 5g
- Price
- $42.63
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0366
- Product name
- 3'-Fluoro-4'-methoxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $50
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0366
- Product name
- 3'-Fluoro-4'-methoxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $144
- Updated
- 2025/07/31
TRC
- Product number
- F593200
- Product name
- 3’-Fluoro-4’methoxyacetophenone
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2617-3-12
- Product name
- 3'-Fluoro-4'-methoxyacetophenone
- Purity
- 98%
- Packaging
- 100g
- Price
- $130
- Updated
- 2021/12/16
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3-Fluoro-4-methoxyacetophenone Chemical Properties,Usage,Production
Uses
3’-Fluoro-4’methoxyacetophenone is used in the synthesis chalcones,
Preparation
Obtained by fluorination of 4-methoxyacetophenone with manganese (IV) tetrafluoride formed in situ using manganese (IV) dioxide and pyridinium polyhydrogenofluoride under very mild conditions.
General Description
3′-Fluoro-4′-methoxyacetophenone can be prepared by Friedel-Crafts reaction of o-fluoroanisole with acetic anhydride.
Synthesis
321-28-8
75-36-5
455-91-4
Under ice bath conditions, 6.38 g (48 mmol) of aluminum trichloride and 40 mL of methylene chloride were added to a 100 mL round bottom flask and stirred until dissolved. Subsequently, 4.68 g (60 mmol) of acetyl chloride was slowly added, keeping the reaction temperature at 5 to 10 °C. Stirring was continued at 5°C for 10 minutes, followed by the slow dropwise addition of 5.04 g (40 mmol) 2-fluoroanisole. After the dropwise addition was completed, the reaction mixture was stirred at 5°C for 1 hour. Upon completion of the reaction, the mixture was carefully poured into 100 mL of ice water to quench the reaction. The aqueous layer was extracted with dichloromethane (2 x 30 mL) and the organic phases were combined. The organic phase was washed sequentially with water (2 x 30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was washed with petroleum ether and finally recrystallized with ethyl acetate to obtain the target product 3-fluoro-4-methoxyacetophenone in 92.4% yield.
References
[1] Patent: CN107686465, 2018, A. Location in patent: Paragraph 0041; 0053; 0054
[2] Patent: US6342510, 2002, B1. Location in patent: Page column 28
[3] Patent: US5098602, 1992, A
[4] Patent: WO2006/136829, 2006, A2. Location in patent: Page/Page column 123
[5] Journal of Organic Chemistry, 1953, vol. 18, p. 910,914
3-Fluoro-4-methoxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluoro-4-methoxyacetophenone manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 3-Fluoro-4-methoxyacetophenone 455-91-4
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
Hebei Yiduo Import and Export Co., Ltd.
- Product
- 3-Fluoro-4-methoxyacetophenone 455-91-4
- Price
- US $100.00-80.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000000
- Release date
- 2025-03-11
Hebei Yanxi Chemical Co., Ltd.
- Product
- 3-Fluoro-4-methoxyacetophenone 455-91-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-29
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