2-Amino-5-bromo-4-methyl-3-nitropyridine

Product Name: 2-Amino-5-bromo-4-methyl-3-nitropyridine
CAS No.: 100367-40-6
Chemical Name: 2-Amino-5-bromo-4-methyl-3-nitropyridine
Synonyms: 2-Ami;2-Amino-5-Bromo-4methyl-3-Np;2-AMINO-3-NITRO-5-BROMO-4-PICOLINE;2-AMINO-5-BROMO-3-NITRO-4-PICOLINE;2-Amino-5-bromo-3-nitro-GAMMA-picoline;5-bromo-4-methyl-3-nitro-2-Pyridinamine;5-bromo-4-methyl-3-nitropyridin-2-amine;2-AMino-5-broMo-3-nitro-4-picoline 98%;2-AMINO-5-BROMO-4-METHYL-3-NITROPYRIDINE;2-AMINO-3-NITRO-4-METHYL-5-BROMOPYRIDINE
CBNumber: CB6489500
Molecular Formula: C6H6BrN3O2
Formula Weight: 232.03
MOL File: 100367-40-6.mol

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2-Amino-5-bromo-4-methyl-3-nitropyridine Property

Melting point:: 160-164
Boiling point:: 314.1±37.0 °C(Predicted)
Density: 1.795±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: 0.78±0.50(Predicted)
form: powder to crystal
color: Light yellow to Brown
CAS DataBase Reference: 100367-40-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2988
Product name: 2-Amino-5-bromo-4-methyl-3-nitropyridine
Purity: >98.0%(T)
Packaging: 1g
Price: $67
Updated: 2025/07/31

TCI Chemical

Product number: A2988
Product name: 2-Amino-5-bromo-4-methyl-3-nitropyridine
Purity: >98.0%(T)
Packaging: 5g
Price: $200
Updated: 2025/07/31

TRC

Product number: A601915
Product name: 2-Amino-5-bromo-4-methyl-3-nitropyridine
Packaging: 10g
Price: $195
Updated: 2021/12/16

TRC

Product number: A601915
Product name: 2-Amino-5-bromo-4-methyl-3-nitropyridine
Packaging: 1g
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-M1656
Product name: 2-Pyridinamine,5-bromo-4-methyl-3-nitro-
Purity: 97.34%
Packaging: 10g
Price: $55
Updated: 2021/12/16

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2-Amino-5-bromo-4-methyl-3-nitropyridine Chemical Properties,Usage,Production

Uses

2-Amino-5-bromo-4-methyl-3-nitropyridine is a pyridine derivative. Its molecular structure contains reactive groups of bromine atoms, amino groups and nitric acid, which can be used in a variety of chemical reactions, such as substitution, condensation, and nitro-reduction reactions. It is mainly used in organic synthesis or pharmaceutical intermediates.

Synthesis

6635-86-5

100367-40-6

Part A: The reaction vessel was first purged with inert gas under inert gas protection. 7.50L of acetic acid was added to the vessel and the temperature was maintained at 20-25°C. Subsequently, 1.00 kg of 4-methyl-3-nitropyridin-2-amine (compound of formula 1) was added to form a yellow suspension. Next, 1.07 kg of sodium acetate was added and the reaction mixture changed to a very thick yellow suspension and a slight exothermic phenomenon was observed. After raising the reaction temperature to about 27°C, the reaction was cooled to 15-20°C and samples were taken for analysis by high pressure liquid chromatography (HPLC). A solution of 1.15 kg of bromine (1.1 eq.) with 2.5 L of acetic acid was prepared and a 10/11 portion (i.e., 1.0 eq.) was added dropwise to the reaction vessel over a period of 10-15 minutes, maintaining the temperature at 15-20°C. A slight exotherm was observed during the dropwise addition and proper cooling was required to maintain the temperature not exceeding 20°C. HPLC analysis was performed immediately after dropwise addition and monitored again after 60 minutes and less than 10% of the starting material was found to be remaining. The remaining bromine solution was added and the reaction was continued with stirring for 30-60 minutes until the reaction was complete. At the end of the reaction, 10.0 L of ice water was added and cooled to 11°C to form a suspension. After continued stirring for 30-60 minutes, the product was collected by filtration and washed with 3 x 2.50 L of ice water. The product was dried at 40°C to constant weight to give 1.45 kg of yellow crystals in 96% yield. The melting point of the product was 132 °C. IR (KBr, cm^-1): 1633, 1581, 1538, 1512, 1458, 1377, 1344, 1321, 1244, 869, 779. 1H-NMR (CDCl3, δ, ppm): 2.55 (s, 3H), 5.85 (bs, 2H), 8.25 (s, 1H) .13C-NMR (CDCl3, δ, ppm): 20.81, 112.14, 144.49, 151.91, 153.78 (2C).MS (M+1): 232.Elemental Analysis: C6H6BrN3O2 Calculated Values: C, 31.05; H, 2.60; N, 18.11; Br, 34.43.Measured Values. 30.95; H, 2.42; N, 17.45; Br, 34.80.

References

[1] Patent: US2006/293304, 2006, A1. Location in patent: Page/Page column 28-29
[2] Patent: US2007/32503, 2007, A1. Location in patent: Page/Page column 8-9; 10
[3] Patent: WO2014/125408, 2014, A2. Location in patent: Page/Page column 38

2-Amino-5-bromo-4-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-bromo-4-methyl-3-nitropyridine Suppliers

Americas 1 Canada 2 China 168 Europe 1 France 3 Germany 3 India 36 Japan 2 The Netherlands 1 United Kingdom 9 United States 39 Global 265

P&S Chemicals

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View Lastest Price from 2-Amino-5-bromo-4-methyl-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-5-bromo-4-methyl-3-nitropyridine 100367-40-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-5-bromo-4-methyl-3-nitropyridine 100367-40-6
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 2-Amino-5-bromo-4-methyl-3-nitropyridine 100367-40-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-26

100367-40-6, 2-Amino-5-bromo-4-methyl-3-nitropyridineRelated Search:

2-Amino-5-bromopyridine 1-Hexadecylpyridinium bromide Glucosamine 2-Amino-5-methylpyridine Methyl acetate METSULFURON METHYL 4-Methyl-3-nitropyridine 3-Aminopyridine Tribenuron methyl 4-Dimethylaminopyridine 2-Aminopyridine EC 2.6.1.2 Methyl salicylate 2-Amino-5-nitropyridine 2-Amino-3-nitropyridine 4-Methylpyridin-2-amine Kresoxim-methyl Thiophanate-methyl

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2-Amino-5-bromo-4-methyl-3-nitropyridine 98%

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2-Amino-5-bromo-4-methyl-3-nitropyridine-2

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5-bromo-4-methyl-3-nitropyridin-2-amine

2-AMino-5-broMo-3-nitro-4-picoline 98%

2-Amino-5-bromo-4-methyl-3-nitropyridine ISO 9001：2015 REACH

2-Amino-5-Bromo-4methyl-3-Np

5-Bromo-4-methyl-3-nitro-pyridin-2-ylamine

2-Amino-5-bromo-3-nitro-4-methylpyridine

100367-40-6

Aromatics

Miscellaneous Reagents

CHIRAL CHEMICALS

Amines

blocks

Bromides

Pyridines

Pyridine