ChemicalBook > CAS DataBase List > SB 200646 HYDROCHLORIDE

SB 200646 HYDROCHLORIDE

Product Name
SB 200646 HYDROCHLORIDE
CAS No.
143797-62-0
Chemical Name
SB 200646 HYDROCHLORIDE
Synonyms
SB-200646A;SB-200646A ，S0893;SB 200646A,SB200646A;SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist;1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride
CBNumber
CB6497473
Molecular Formula
C15H14N4O.ClH
Formula Weight
302.763
MOL File
143797-62-0.mol
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SB 200646 HYDROCHLORIDE Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: ~26 mg/mL, soluble
form 
solid
color 
pale yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
S155033
Product name
SB200646Hydrochloride
Packaging
50mg
Price
$865
Updated
2021/12/16
ChemScene
Product number
CS-0024588
Product name
SB-200646A
Purity
99.47%
Packaging
5mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
9177CN
Product name
SB200646hydrochloride
Packaging
1mg
Price
$133
Updated
2021/12/16
ChemScene
Product number
CS-0024588
Product name
SB-200646A
Purity
99.47%
Packaging
10mg
Price
$145
Updated
2021/12/16
ApexBio Technology
Product number
B5104
Product name
SB200646hydrochloride
Packaging
10mg
Price
$228
Updated
2021/12/16
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SB 200646 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

SB 200646 Hydrochloride is a 5-HT2C antagonist.

in vivo

SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].

Animal Model:Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1]
Dosage:20 mg/kg
Administration:Intravenous injection; daily; for 21 days
Result:Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.

IC 50

5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)

SB 200646 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 200646 HYDROCHLORIDE Suppliers

China 27 Switzerland 1 United Kingdom 1 United States 8 USA 1 Global 38
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4810
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
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58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58

143797-62-0, SB 200646 HYDROCHLORIDERelated Search:

SB-756050 MMP-2/MMP-9 INHIBITOR IV SB 200646 HYDROCHLORIDE m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate SB 202190 SB 431542 SB 743921 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime Pracinostat 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 SB 225002 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

  • SB-200646A
  • SB 200646A,SB200646A
  • SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist
  • 1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride
  • SB-200646A ，S0893
  • 143797-62-0
  • C15H14N4OHCl05H2O