Temocaprilat

Product Name: Temocaprilat
CAS No.: 110221-53-9
Chemical Name: Temocaprilat
Synonyms: Temocaprilate;RS-5139;Temocaprilat;[3H]-Temocaprilat;Temocapril Diacid;Temocapril Impurity 1;TEMOCAPRILAT(FORR&DONLY);Temocaprilat, 10 mM in DMSO;[[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid;(2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid
CBNumber: CB6501004
Molecular Formula: C21H24N2O5S2
Formula Weight: 448.56
MOL File: 110221-53-9.mol

More

Less

Temocaprilat Property

Melting point:: >2300C (dec)
alpha: 25D +63.4° (c = 1 in DMF)
Boiling point:: 743.6±60.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 2.09±0.10(Predicted)
color: White to Off-White

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 22169
Product name: Temocaprilat
Packaging: 500μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 22169
Product name: Temocaprilat
Packaging: 1mg
Price: $218
Updated: 2024/03/01

Cayman Chemical

Product number: 22169
Product name: Temocaprilat
Packaging: 5mg
Price: $722
Updated: 2024/03/01

TRC

Product number: T017305
Product name: Temocaprilat
Packaging: 1g
Price: $1015
Updated: 2021/12/16

AK Scientific

Product number: O437
Product name: Temocaprilat
Packaging: 1g
Price: $1366
Updated: 2021/12/16

More

Less

Temocaprilat Chemical Properties,Usage,Production

Description

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀ = 3.6 nM for rabbit lung ACE). It inhibits contraction of isolated rat aorta induced by angiotensin I with an IC₅₀ value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.

Chemical Properties

White to Off-White Solid

Uses

Antihypertensive.

Definition

ChEBI: Temocaprilat is a non-proteinogenic alpha-amino acid.

in vivo

Temocaprilat (1 mg/kg/d; i.v.; 4 weeks) significantly reduces systolic blood pressure with time-dependent manner in spontaneously hypertensive (SHR) rats. Temocaprilat improves myocardial fibrosis and oxidative stress in Wistar-Kyoto (WKY) rats and SHR rats^[3].

Animal Model:	Six 10-week-old WKYs and SHRs and six 50-week-old (aging control) SHRs^[3].
Dosage:	1 mg/kg/d.
Administration:	Intravenous injection; 4 weeks.
Result:	Reduced the expression levels of myocardial fibrosis, transforming growth factor-β1 (TGF-β1) mRNA and fibroblast growth factor-2 (FGF-2) mRNA in the left ventricle (LV). Weakened the expression levels of 8-isoprostane, p22phox mRNA, p47phox mRNA and gp91phox mRNA in LV.

References

[1] KIYOSHI OIZUMI . Pharmacological Profiles of CS-622, a Novel Angiotensin Converting Enzyme Inhibitor[J]. Japanese journal of pharmacology, 1988, 48 3: Pages 349-356. DOI: 10.1254/jjp.48.349

Temocaprilat Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Temocaprilat Suppliers

Canada 1 China 47 India 1 United Kingdom 1 United States 11 Global 61

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Aobo pharmaceutical Technology Co., Ltd

Tel: 86-21-51320499
Fax: 86-21-51320368
Email: aobo@aobopharm.com
Country: China
ProdList: 297
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@qq.com
Country: China
ProdList: 10000
Advantage: 55

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

110221-53-9, TemocaprilatRelated Search:

Tris(hydroxymethyl)aminomethane 2-Aminophenol Glycine Thifensulfuron Cephalothin sodium 1,1'-Carbonyldiimidazole 6-Aminocaproic acid ALTRENOGEST Tetrahydrothiophene Temocapril hydrochloride (2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one 2-Thienylmethanethiol Carbonyl iron powder 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid L-β-Homophenylalanine, HPLC 98% TEMOCAPRIL-D5 1-(2'-THIENYL)ETHYLMERCAPTAN Temocaprilat

[3H]-Temocaprilat

RS-5139

TEMOCAPRILAT(FORR&DONLY)

(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid

[[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid

(2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid

Temocapril Diacid

Temocaprilate

Temocaprilat

1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)-

Temocapril Impurity 1

Temocaprilat, 10 mM in DMSO

110221-53-9

C21H24N2O5S2

Intermediates & Fine Chemicals

Pharmaceuticals