ChemicalBook > CAS DataBase List > Temocaprilat

Temocaprilat

Product Name: Temocaprilat
CAS No.: 110221-53-9
Chemical Name: Temocaprilat
Synonyms: Temocaprilate;RS-5139;Temocaprilat;[3H]-Temocaprilat;Temocapril Diacid;Temocapril Impurity 1;TEMOCAPRILAT(FORR&DONLY);Temocaprilat, 10 mM in DMSO;[[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid;(2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid
CBNumber: CB6501004
Molecular Formula: C21H24N2O5S2
Formula Weight: 448.56
MOL File: 110221-53-9.mol

Less

Temocaprilat Property

Melting point:: >2300C (dec)
alpha: 25D +63.4° (c = 1 in DMF)
Boiling point:: 743.6±60.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 2.09±0.10(Predicted)
color: White to Off-White

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 22169
Product name: Temocaprilat
Packaging: 500μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 22169
Product name: Temocaprilat
Packaging: 1mg
Price: $218
Updated: 2024/03/01

Cayman Chemical

Product number: 22169
Product name: Temocaprilat
Packaging: 5mg
Price: $722
Updated: 2024/03/01

TRC

Product number: T017305
Product name: Temocaprilat
Packaging: 1g
Price: $1015
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000849
Product name: TEMOCAPRILAT
Purity: 95.00%
Packaging: 1MG
Price: $292.95
Updated: 2021/12/16

Less

Temocaprilat Chemical Properties,Usage,Production

Description

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀ = 3.6 nM for rabbit lung ACE). It inhibits contraction of isolated rat aorta induced by angiotensin I with an IC₅₀ value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.

Chemical Properties

White to Off-White Solid

Uses

Antihypertensive.

Definition

ChEBI: Temocaprilat is a non-proteinogenic alpha-amino acid.

in vivo

Temocaprilat (1 mg/kg/d; i.v.; 4 weeks) significantly reduces systolic blood pressure with time-dependent manner in spontaneously hypertensive (SHR) rats. Temocaprilat improves myocardial fibrosis and oxidative stress in Wistar-Kyoto (WKY) rats and SHR rats^[3].

Animal Model:	Six 10-week-old WKYs and SHRs and six 50-week-old (aging control) SHRs^[3].
Dosage:	1 mg/kg/d.
Administration:	Intravenous injection; 4 weeks.
Result:	Reduced the expression levels of myocardial fibrosis, transforming growth factor-β1 (TGF-β1) mRNA and fibroblast growth factor-2 (FGF-2) mRNA in the left ventricle (LV). Weakened the expression levels of 8-isoprostane, p22phox mRNA, p47phox mRNA and gp91phox mRNA in LV.

References

[1] KIYOSHI OIZUMI . Pharmacological Profiles of CS-622, a Novel Angiotensin Converting Enzyme Inhibitor[J]. Japanese journal of pharmacology, 1988, 48 3: Pages 349-356. DOI: 10.1254/jjp.48.349

Temocaprilat Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Temocaprilat Suppliers

Canada 1 China 47 India 1 United Kingdom 1 United States 11 Global 61

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Aobo pharmaceutical Technology Co., Ltd

Tel: 86-21-51320499
Fax: 86-21-51320368
Email: aobo@aobopharm.com
Country: China
ProdList: 297
Advantage: 57

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@yongstandards.com
Country: China
ProdList: 10000
Advantage: 55

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Hubei Xinyang Medical Technology Co., Ltd

Tel: 15347293736
Fax: QQ：2853117752
Email: 2853117764@yongstandards.com
Country: China
ProdList: 9996
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 17392282731
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9992
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9958
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4970
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9765
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11146
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49934
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Guangzhou Weisheng Biotechnology Co., Ltd.

Tel: 17765667235
Country: CHINA
ProdList: 129
Advantage: 58

Guangzhou Qiansheng Biotechnology Co., Ltd.

Tel: 14748676110
Country: CHINA
ProdList: 112
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Shanghai yiji industries Co., Ltd.

Tel: --
Fax: --
Email: yiji01@foxmail.com
Country: China
ProdList: 6021
Advantage: 50

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6655
Advantage: 58

Beijing Baiao Innovation Technology Co., Ltd.

Tel: --
Fax: --
Email: 3007606172@qq.com
Country: CHINA
ProdList: 6002
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6525
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: --
Fax: --
Email: kexianxun@gmail.com
Country: China
ProdList: 1037
Advantage: 50

Lanospharma Laboratories Co.,Ltd

Tel: --
Fax: --
Email: sales@lanospharma.com
Country: China
ProdList: 6329
Advantage: 56

Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd

Tel: --
Fax: --
Email: sales@yickvic.com
Country: China
ProdList: 6206
Advantage: 58

110221-53-9, TemocaprilatRelated Search:

Tris(hydroxymethyl)aminomethane 2-Aminophenol Glycine Thifensulfuron Cephalothin sodium 1,1'-Carbonyldiimidazole 6-Aminocaproic acid ALTRENOGEST Tetrahydrothiophene Temocapril hydrochloride (2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one 2-Thienylmethanethiol Carbonyl iron powder 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid L-β-Homophenylalanine, HPLC 98% TEMOCAPRIL-D5 1-(2'-THIENYL)ETHYLMERCAPTAN Temocaprilat

[3H]-Temocaprilat

RS-5139

TEMOCAPRILAT(FORR&DONLY)

(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid

[[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid

(2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid

Temocapril Diacid

Temocaprilate

Temocaprilat

1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)-

Temocapril Impurity 1

Temocaprilat, 10 mM in DMSO

110221-53-9

C21H24N2O5S2

Intermediates & Fine Chemicals

Pharmaceuticals