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Temocaprilat

Product Name
Temocaprilat
CAS No.
110221-53-9
Chemical Name
Temocaprilat
Synonyms
Temocaprilate;RS-5139;Temocaprilat;[3H]-Temocaprilat;Temocapril Diacid;Temocapril Impurity 1;TEMOCAPRILAT(FORR&DONLY);[[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid;(2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)-
CBNumber
CB6501004
Molecular Formula
C21H24N2O5S2
Formula Weight
448.56
MOL File
110221-53-9.mol
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Temocaprilat Property

Melting point:
>2300C (dec)
alpha 
25D +63.4° (c = 1 in DMF)
Boiling point:
743.6±60.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.09±0.10(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22169
Product name
Temocaprilat
Packaging
500μg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
22169
Product name
Temocaprilat
Packaging
1mg
Price
$218
Updated
2024/03/01
Cayman Chemical
Product number
22169
Product name
Temocaprilat
Packaging
5mg
Price
$722
Updated
2024/03/01
TRC
Product number
T017305
Product name
Temocaprilat
Packaging
1g
Price
$1015
Updated
2021/12/16
AK Scientific
Product number
O437
Product name
Temocaprilat
Packaging
1g
Price
$1366
Updated
2021/12/16
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Temocaprilat Chemical Properties,Usage,Production

Description

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 3.6 nM for rabbit lung ACE). It inhibits contraction of isolated rat aorta induced by angiotensin I with an IC50 value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.

Chemical Properties

White to Off-White Solid

Uses

Antihypertensive.

Definition

ChEBI: Temocaprilat is a non-proteinogenic alpha-amino acid.

Temocaprilat Preparation Products And Raw materials

Raw materials

Preparation Products

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Temocaprilat Suppliers

Canada 1 China 39 India 1 United Kingdom 1 United States 11 Global 53
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58

110221-53-9, TemocaprilatRelated Search:

2-Aminophenol Glycine Thifensulfuron Cephalothin sodium Tris(hydroxymethyl)aminomethane 1,1'-Carbonyldiimidazole 6-Aminocaproic acid ALTRENOGEST Tetrahydrothiophene Temocapril hydrochloride (2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one 2-Thienylmethanethiol Carbonyl iron powder 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid L-β-Homophenylalanine, HPLC 98% TEMOCAPRIL-D5 1-(2'-THIENYL)ETHYLMERCAPTAN Temocaprilat

  • [3H]-Temocaprilat
  • RS-5139
  • TEMOCAPRILAT(FORR&DONLY)
  • (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid
  • [[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid
  • (2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid
  • Temocapril Diacid
  • Temocaprilate
  • Temocaprilat
  • 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)-
  • Temocapril Impurity 1
  • 110221-53-9
  • C21H24N2O5S2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals