ChemicalBook > CAS DataBase List > 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER

2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER

Product Name: 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER
CAS No.: 393-85-1
Chemical Name: 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER
Synonyms: METHYL 5-FLUORO-2-NITROBENZOATE;RARECHEM AL BF 0375;5-fluoro-3-methyl-2-nitrobenzoate;Methyl5-fluoro-2-nitrobenzoate98%;Methyl 5-fluoro-2-nitrobenzoate 98%;5-Fluor-2-nitrobenzoesuremethylester;3-Methoxycarbonyl-4-nitrofluorobenzene;2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER;5-FLUORO-2-NITRO-BENZOIC ACID METHYL ESTER;Benzoic acid,5-fluoro-2-nitro-, methyl ester
CBNumber: CB6678063
Molecular Formula: C8H6FNO4
Formula Weight: 199.14
MOL File: 393-85-1.mol

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2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER Property

Melting point:: 40-42°C
Boiling point:: 282℃
Density: 1.388
Flash point:: 124℃
storage temp.: Sealed in dry,Room Temperature
solubility: Acetone, DMSO
form: Low Melting Solid
color: White
Water Solubility: Slightly soluble in water. Soluble in dimethyl sulfoxide and acetone.
InChI: InChI=1S/C8H6FNO4/c1-14-8(11)6-4-5(9)2-3-7(6)10(12)13/h2-4H,1H3
InChIKey: LCAUVFVOLNRVKG-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC(F)=CC=C1[N+]([O-])=O

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: N495885
Product name: 2-Nitro-5-fluorobenzoicAcid,MethylEster
Packaging: 2g
Price: $530
Updated: 2021/12/16

TRC

Product number: N495885
Product name: 2-Nitro-5-fluorobenzoicAcid,MethylEster
Packaging: 1g
Price: $275
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 12557
Product name: 2-Nitro-5-fluorobenzoicAcidMethylEster
Packaging: 12.5g
Price: $1760
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0026513
Product name: METHYL 5-FLUORO-2-NITROBENZOATE
Purity: 95.00%
Packaging: 100G
Price: $2997.23
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 12557
Product name: 2-Nitro-5-fluorobenzoicAcidMethylEster
Packaging: 2.5g
Price: $845
Updated: 2021/12/16

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2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-White to Yellow Solid

Uses

2-Nitro-5-fluorobenzoic Acid, Methyl Ester (cas# 393-85-1) is a compound useful in organic synthesis.

Synthesis

67-56-1

320-98-9

393-85-1

4-Fluoro-2-nitrobenzoic acid (4 g, 21.6 mmol) was dissolved in 40 mL of methanol at 0 °C and 8.0 mL of concentrated sulfuric acid was slowly added. The reaction mixture was warmed to 60 °C and stirred continuously for 16 hours. Upon completion of the reaction, it was cooled to room temperature and the pH was adjusted with aqueous potassium carbonate to 8. Subsequently, the organic solvent was evaporated under reduced pressure. The remaining aqueous phase was extracted with ethyl acetate, the organic phases were combined and dried over anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to afford the red oily product methyl 2-nitro-5-fluorobenzoate (3.6 g, 82% yield). Mass spectrometry (ESI positive ion mode): m/z = 200 [M + H]+. LC-MS analytical conditions [Method 4, gradient elution: starting solvent water (containing 0.05% trifluoroacetic acid)-acetonitrile, initial acetonitrile ratio 10%]: retention time Rt = 1.01 min.

References

[1] Patent: WO2018/172250, 2018, A1. Location in patent: Page/Page column 385-386
[2] Patent: US2010/280268, 2010, A1. Location in patent: Page/Page column 57
[3] Patent: US2010/249158, 2010, A1. Location in patent: Page/Page column 16
[4] Patent: EP1810969, 2007, A1. Location in patent: Page/Page column 58

2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER Suppliers

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View Lastest Price from 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 5-fluoro-2-nitrobenzoate 393-85-1
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-07

Honest Joy Holdings Limited

Product: 2-nitro-5-fluorobenzoic acid methyl ester 393-85-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-02-18

Career Henan Chemical Co

Product: 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER 393-85-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

393-85-1, 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTERRelated Search:

Methyl dihydrojasmonate Methyl salicylate 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER METHYL 6-AMINO-1H-INDOLE-2-CARBOXYLATE METHYL 5-BROMO-2-IODOBENZOATE METHYL 2-METHYL-5-FLUOROBENZOATE METHYL 5-FLUORO-2-HYDROXYBENZOATE 3-nitro-4-fluorobenzoic acid methyl ester 2-Amino-5-fluorobenzoic acid 5-Fluoro-2-nitrotoluene 5-Fluoro-2-nitrobenzadehyde 5-Fluoro-2-nitrobenzoic acid 2-Amino-5-fluorobenzoic acid methyl ester 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER 5-FLUORO-2-NITROBENZOIC ACID ETHYL ESTER 4,5-DIFLUORO-2-NITROBENZOIC ACID ETHYL ESTER

METHYL 5-FLUORO-2-NITROBENZOATE

5-FLUORO-2-NITRO-BENZOIC ACID METHYL ESTER

2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER

RARECHEM AL BF 0375

Methyl 5-fluoro-2-nitrobenzoate 98%

Methyl5-fluoro-2-nitrobenzoate98%

5-Fluor-2-nitrobenzoesuremethylester

3-Methoxycarbonyl-4-nitrofluorobenzene

Benzoic acid,5-fluoro-2-nitro-, methyl ester

5-fluoro-3-methyl-2-nitrobenzoate

393-85-1

Aromatic Esters

Aromatics Compounds

Aromatics