Sertaconazole nitrate
- Product Name
- Sertaconazole nitrate
- CAS No.
- 99592-32-2
- Chemical Name
- Sertaconazole nitrate
- Synonyms
- SERTACONAZOLE;eno;Zalain;FI-7056;fi-7045;Dermofix;Sertaconazol;Sertaconazole API;Sertaconazole nitrate;Sertaconazole nitrate USP/EP/BP
- CBNumber
- CB6701774
- Molecular Formula
- C20H15Cl3N2OS
- Formula Weight
- 437.77
- MOL File
- 99592-32-2.mol
Sertaconazole nitrate Property
- Melting point:
- 146-147°
- Boiling point:
- 614.1±55.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.68±0.12(Predicted)
- color
- White to Pale Yellow
- CAS DataBase Reference
- 99592-32-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- orb134711
- Product name
- Sertaconazole nitrate
- Purity
- >99%
- Packaging
- 100mg
- Price
- $510
- Updated
- 2021/12/16
- Product number
- orb134711
- Product name
- Sertaconazole nitrate
- Purity
- >99%
- Packaging
- 250mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- 18771
- Product name
- Sertaconazole
- Packaging
- 25mg
- Price
- $1500
- Updated
- 2021/12/16
- Product number
- orb134711
- Product name
- Sertaconazole nitrate
- Purity
- >99%
- Packaging
- 1g
- Price
- $1504.5
- Updated
- 2021/12/16
- Product number
- API-1214
- Product name
- Sertaconazole nitrate
- Purity
- 98%
- Packaging
- 1g
- Price
- $810
- Updated
- 2021/12/16
Sertaconazole nitrate Chemical Properties,Usage,Production
Description
Sertaconazole has been developed and launched for the treatment of dermatological fungal infections by Ferrer Internacional S. A. Mylan received FDA approval for sertaconazole nitrate cream for the treatment of athlete's foot (tinea pedis) at the end of 2003.
Uses
An imidazole antifungal agent, inhibits the synthesis of ergosterol, an essential cell wall component of fungi.
Definition
ChEBI: 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that carries a 2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. It is a dichlorobenzene, an ether, a member of imidazoles and a member of 1-benzothiophenes.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as yeasts and dermatophytes. New formulations for the treatment of vaginal mycoses are in development.
Antimicrobial activity
Sertaconazole is a rather new broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi. It also has excellent activity against pathogenic yeasts.
Synthesis
2,4-Dichloro acetophenone 169 was brominated at low temperature to give bromide intermediate 170, which was used without isolation. To the same pot, five-fold excess of imidazole was added to give imidazolylacetophenone 171 in 71% yield from 169. Sodium borohydride was employed to reduce ketone 171 to alcohol 172 in 78% yield. Racemic alcohol 172 was resolved with (-)-DIP-chloride to give its corresponding chiral R-alcohol 173 in 80% yield. Compound 173 was then alkylated with 3-bromomethyl-7-chlorobenzo[b]thiophene (174) in dry DMF in the presence of potassium t-butoxide to give the alkylation product in 68% yield. Finally, 60% nitric acid was used to make sertaconazole mononitrate (XXI) in 89% yield.
Solubility in organics
Fairly soluble in ethanol (1.7 %), chloroform (1.5 %); slightly soluble in acetone (0.95 %); very slightly soluble in noctanol (0.069 %). Practically insoluble in water (< 0.01 %).
Sertaconazole nitrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sertaconazole nitrate manufacturers
- Product
- Sertaconazole nitrate 99592-32-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 500kg/month
- Release date
- 2021-07-01
- Product
- Flunixin meglumine 99592-32-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-07-30
- Product
- Flunixin meglumine 99592-32-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-28