PYRIDINE-2-CARBOXAMIDE

Product Name: PYRIDINE-2-CARBOXAMIDE
CAS No.: 1452-77-3
Chemical Name: PYRIDINE-2-CARBOXAMIDE
Synonyms: PICOLINAMIDE;2-PICOLINAMIDE;Picolinoylamide;PicolinaMide 98%;Picolinamide ,98%;2-Picolinamide>alpha-Picolinamide;TIMTEC-BB SBB008128;2-Carbamoylpyridine;Picolinic acid amide
CBNumber: CB6713827
Molecular Formula: C6H6N2O
Formula Weight: 122.12
MOL File: 1452-77-3.mol

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PYRIDINE-2-CARBOXAMIDE Property

Melting point:: 110 °C (dec.)(lit.)
Boiling point:: 143 °C / 20mmHg
Density: 1.2236 (rough estimate)
refractive index: 1.5350 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: pK1: 2.10(+1) (20°C)
form: Solid
color: White to Off-White
BRN: 109617
CAS DataBase Reference: 1452-77-3(CAS DataBase Reference)
EPA Substance Registry System: 2-Pyridinecarboxamide (1452-77-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
TSCA: Yes
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 104051
Product name: Picolinamide
Purity: 98%
Packaging: 10g
Price: $49.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 104051
Product name: Picolinamide
Purity: 98%
Packaging: 50g
Price: $237
Updated: 2024/03/01

TCI Chemical

Product number: P0414
Product name: 2-Picolinamide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $105
Updated: 2024/03/01

Alfa Aesar

Product number: A15410
Product name: Pyridine-2-carboxamide, 98%
Packaging: 5g
Price: $43.65
Updated: 2024/03/01

Alfa Aesar

Product number: A15410
Product name: Pyridine-2-carboxamide, 98%
Packaging: 25g
Price: $169.65
Updated: 2024/03/01

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PYRIDINE-2-CARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO₄.

Uses

A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.

Definition

ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid.

Biological Activity

picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.

Biochem/physiol Actions

Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.

in vitro

the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1].

in vivo

picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2].

References

[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92.

PYRIDINE-2-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Potassium carbonate Dichloromethane Dimethyl sulfoxide Sodium hydroxide 2-Cyanopyridine Sulfuric acid

Preparation Products

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PYRIDINE-2-CARBOXAMIDE Suppliers

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View Lastest Price from PYRIDINE-2-CARBOXAMIDE manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: PYRIDINE-2-CARBOXAMIDE 1452-77-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-13

Hebei Weibang Biotechnology Co., Ltd

Product: PYRIDINE-2-CARBOXAMIDE 1452-77-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Career Henan Chemical Co

Product: PYRIDINE-2-CARBOXAMIDE 1452-77-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

1452-77-3, PYRIDINE-2-CARBOXAMIDERelated Search:

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Isonicotinamide Nicotinamide 2,4-Pyridinedicarboxylic acid, 2-Methyl ester Pyridine hydrofluoride 4-AMIDINOPYRIDINE HYDROCHLORIDEPYRIDINE-4-CARBOXIMIDAMIDE HYDROCHLORIDE 3-(2-PYRIDYL)ACRYLIC ACID Nicotinic acid NAD+ β-Nicotinamide Mononucleotide Nicotinamide-N-oxide 3-Cyanopyridine Pyridine-3-sulfonyl chloride hydrochloride PYRIDINE-3-SULFONIC ACID SODIUM SALT PYRIDINE-2,4-DICARBONITRILE Pyridine, 4-(diethylboryl)- Pyridine, 3-(3-ethoxyandrosta-5,16-dien-17-yl)- Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]- Picolinamide

alpha-Picolinic acid amide

Picolinic acid amide

Picolinoylamide

Pyridine-2-carboxylicamide

2-PYRIDINECARBOXAMIDE

Isoniazid Impurity I

Nicotinamide EP Impurity C

2-PICOLINAMIDE

PICOLINAMIDE

PYRIDINE-2-CARBOXYLIC ACID AMIDE

PYRIDINE-2-CARBOXAMIDE

TIMTEC-BB SBB008128

Picolinamide ,98%

Picolinamide,2-Pyridinecarboxamide

PicolinaMide 98%

2-Carbamoylpyridine

alpha-Picolinamide

Nicotinamide Impurity 3(Nicotinamide EP Impurity C)

2-Picolinamide&gt

2-Picolinamide, 98%, for synthesis

PYRIDINE-2-CARBOXAMIDE ISO 9001：2015 REACH

2-aminocarbonyl-pyridine

2-Pyridinecarboxamide (9CI, ACI)

pyridine-2-carboxamide (picolinamide)

Nicotinamide Impurity C

Nicotinamide EP Impurity C（Picolinamide）

Pyridin-2-carboxamide

Picolinamide, 10 mM in DMSO

1452-77-3

Heterocyclic Building Blocks

Pyridines

C6

Building Blocks

Amines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocyclic Compounds